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Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)

  • Authors:
    • Chunzhi Zhang
    • Siyuan Liang
    • Hanning Zhang
    • Ruoxi Wang
    • Huanhuan Qiao
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Tianjin Hospital, Tianjin University, Tianjin 300211, P.R. China, Functional Materials Laboratory, Institute of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300211, P.R. China, Clinical Medical College of Tianjin Medical University, Tianjin 300270, P.R. China, Sophomore, Farragut School #3 of Yangtai Road, Tianjin 300042, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 28
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    Published online on: December 19, 2023
       https://doi.org/10.3892/or.2023.8687
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Abstract

Plasticity, the ability of cancer cells to transition between differentiation states without genomic alterations, has been recognized as a major source of intratumoral heterogeneity. It has a crucial role in cancer metastasis and treatment resistance. Thus, targeting plasticity holds tremendous promise. However, the molecular mechanisms of plasticity in cancer cells remain poorly understood. Several studies found that mRNA, which acts as a bridge linking the genetic information of DNA and protein, has an important role in translating genotypes into phenotypes. The present review provided an overview of the regulation of cancer cell plasticity occurring via changes in the transcription and editing of mRNAs. The role of the transcriptional regulation of mRNA in cancer cell plasticity was discussed, including DNA‑binding transcriptional factors, DNA methylation, histone modifications and enhancers. Furthermore, the role of mRNA editing in cancer cell plasticity was debated, including mRNA splicing and mRNA modification. In addition, the role of non‑coding (nc)RNAs in cancer plasticity was expounded, including microRNAs, long intergenic ncRNAs and circular RNAs. Finally, different strategies for targeting cancer cell plasticity to overcome metastasis and therapeutic resistance in cancer were discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Liang S, Zhang H, Wang R and Qiao H: Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review). Oncol Rep 51: 28, 2024.
APA
Zhang, C., Liang, S., Zhang, H., Wang, R., & Qiao, H. (2024). Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review). Oncology Reports, 51, 28. https://doi.org/10.3892/or.2023.8687
MLA
Zhang, C., Liang, S., Zhang, H., Wang, R., Qiao, H."Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)". Oncology Reports 51.2 (2024): 28.
Chicago
Zhang, C., Liang, S., Zhang, H., Wang, R., Qiao, H."Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)". Oncology Reports 51, no. 2 (2024): 28. https://doi.org/10.3892/or.2023.8687
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Liang S, Zhang H, Wang R and Qiao H: Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review). Oncol Rep 51: 28, 2024.
APA
Zhang, C., Liang, S., Zhang, H., Wang, R., & Qiao, H. (2024). Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review). Oncology Reports, 51, 28. https://doi.org/10.3892/or.2023.8687
MLA
Zhang, C., Liang, S., Zhang, H., Wang, R., Qiao, H."Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)". Oncology Reports 51.2 (2024): 28.
Chicago
Zhang, C., Liang, S., Zhang, H., Wang, R., Qiao, H."Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review)". Oncology Reports 51, no. 2 (2024): 28. https://doi.org/10.3892/or.2023.8687
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