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Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review)

  • Authors:
    • Tianyu Huang
    • Longmei Fan
    • Jiajia Tang
    • Shicheng Chen
    • Guotu Du
    • Neng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China, Department of Urology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 10
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    Published online on: November 12, 2024
       https://doi.org/10.3892/or.2024.8843
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Abstract

Bladder cancer is the most common malignant tumor of the urinary system with high morbidity and no clear pathogenesis. The Hippo signaling pathway is an evolutionarily conserved pathway that regulates organ size and maintains tissue homeostasis. Yes‑associated protein 1 (YAP1) is a key effector of this pathway and regulates downstream target genes by binding to transcriptional co‑activators with PDZ binding sequences (TAZ). Several studies have demonstrated that YAP1 is overexpressed in bladder cancer and is involved in adverse outcomes such as bladder cancer occurrence, progression, resistance to cisplatin and the recurrence of tumours. The present review summarized the involvement of YAP1 in bladder cancer disease onset and progression, and the mechanism of YAP1 involvement in bladder cancer treatment. In addition, this study further explored the potential of YAP1 in the diagnosis and treatment of bladder cancer. This study aimed to explore the potential mechanism of YAP1 in the treatment of bladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Huang T, Fan L, Tang J, Chen S, Du G and Zhang N: Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review). Oncol Rep 53: 10, 2025.
APA
Huang, T., Fan, L., Tang, J., Chen, S., Du, G., & Zhang, N. (2025). Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review). Oncology Reports, 53, 10. https://doi.org/10.3892/or.2024.8843
MLA
Huang, T., Fan, L., Tang, J., Chen, S., Du, G., Zhang, N."Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review)". Oncology Reports 53.1 (2025): 10.
Chicago
Huang, T., Fan, L., Tang, J., Chen, S., Du, G., Zhang, N."Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review)". Oncology Reports 53, no. 1 (2025): 10. https://doi.org/10.3892/or.2024.8843
Copy and paste a formatted citation
x
Spandidos Publications style
Huang T, Fan L, Tang J, Chen S, Du G and Zhang N: Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review). Oncol Rep 53: 10, 2025.
APA
Huang, T., Fan, L., Tang, J., Chen, S., Du, G., & Zhang, N. (2025). Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review). Oncology Reports, 53, 10. https://doi.org/10.3892/or.2024.8843
MLA
Huang, T., Fan, L., Tang, J., Chen, S., Du, G., Zhang, N."Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review)". Oncology Reports 53.1 (2025): 10.
Chicago
Huang, T., Fan, L., Tang, J., Chen, S., Du, G., Zhang, N."Advances in research on the carcinogenic mechanisms and therapeutic potential of YAP1 in bladder cancer (Review)". Oncology Reports 53, no. 1 (2025): 10. https://doi.org/10.3892/or.2024.8843
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