Open Access

Roles of PEG10 in cancer and neurodegenerative disorder (Review)

  • Authors:
    • Dachao Mou
    • Shasha Wu
    • Yanqiong Chen
    • Yun Wang
    • Yufang Dai
    • Min Tang
    • Xiu Teng
    • Shijun Bai
    • Xiufeng Bai
  • View Affiliations

  • Published online on: April 1, 2025     https://doi.org/10.3892/or.2025.8893
  • Article Number: 60
  • Copyright: © Mou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paternally expressed gene 10 (PEG10) is an imprinting gene. In addition to its known roles in placental development, as well as mouse embryonic stem cell and trophoblast stem cell differentiation, PEG10 has recently been shown to have significance in cancers. High expression of PEG10 is observed in various cancer types and is associated with poor prognosis. Of note, disruption of PEG10 expression leads to increased apoptosis, as well as decreased proliferation, invasion and migration of cancer cells. PEG10 is expected to become a target for cancer and neurodegenerative disorder therapy. This article reviewed the latest progress in the role of PEG10 in cancers.
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May-2025
Volume 53 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Mou D, Wu S, Chen Y, Wang Y, Dai Y, Tang M, Teng X, Bai S and Bai X: Roles of PEG10 in cancer and neurodegenerative disorder (Review). Oncol Rep 53: 60, 2025.
APA
Mou, D., Wu, S., Chen, Y., Wang, Y., Dai, Y., Tang, M. ... Bai, X. (2025). Roles of PEG10 in cancer and neurodegenerative disorder (Review). Oncology Reports, 53, 60. https://doi.org/10.3892/or.2025.8893
MLA
Mou, D., Wu, S., Chen, Y., Wang, Y., Dai, Y., Tang, M., Teng, X., Bai, S., Bai, X."Roles of PEG10 in cancer and neurodegenerative disorder (Review)". Oncology Reports 53.5 (2025): 60.
Chicago
Mou, D., Wu, S., Chen, Y., Wang, Y., Dai, Y., Tang, M., Teng, X., Bai, S., Bai, X."Roles of PEG10 in cancer and neurodegenerative disorder (Review)". Oncology Reports 53, no. 5 (2025): 60. https://doi.org/10.3892/or.2025.8893