|
1
|
Sanders M and Grundmann O: The use of
glucosamine, devil's claw (Harpagophytum procumbens), and
acupuncture as complementary and alternative treatments for
osteoarthritis. Altern Med Rev. 16:228–238. 2011.PubMed/NCBI
|
|
2
|
Zhu X, Sang L, Wu D, Rong J and Jiang L:
Effectiveness and safety of glucosamine and chondroitin for the
treatment of osteoarthritis: A meta-analysis of randomized
controlled trials. J Orthop Surg Res. 13:1702018. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Wang LS, Chen SJ, Zhang JF, Liu MN, Zheng
JH and Yao XD: Anti-proliferative potential of Glucosamine in renal
cancer cells via inducing cell cycle arrest at G0/G1 phase. BMC
Urol. 17:382017. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Zahedipour F, Dalirfardouei R, Karimi G
and Jamialahmadi K: Molecular mechanisms of anticancer effects of
Glucosamine. Biomed Pharmacother. 95:1051–1058. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kim DS, Park KS, Jeong KC, Lee BI, Lee CH
and Kim SY: Glucosamine is an effective chemo-sensitizer via
transglutaminase 2 inhibition. Cancer Lett. 273:243–249. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Oh HJ, Lee JS, Song DK, Shin DH, Jang BC,
Suh SI, Park JW, Suh MH and Baek WK: D-glucosamine inhibits
proliferation of human cancer cells through inhibition of p70S6K.
Biochem Biophys Res Commun. 360:840–845. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Jo JR, Park YK and Jang BC: Short-term
treatment with glucosamine hydrochloride specifically downregulates
hypoxia-inducible factor-1α at the protein level in YD-8 human
tongue cancer cells. Int J Oncol. 44:1699–1706. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Chou WY, Chuang KH, Sun D, Lee YH, Kao PH,
Lin YY, Wang HW and Wu YL: Inhibition of PKC-Induced COX-2 and IL-8
expression in human breast cancer cells by glucosamine. J Cell
Physiol. 230:2240–2251. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Song KH, Kang JH, Woo JK, Nam JS, Min HY,
Lee HY, Kim SY and Oh SH: The novel IGF-IR/Akt-dependent anticancer
activities of glucosamine. BMC Cancer. 14:312014. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Cura AJ and Carruthers A: Role of
monosaccharide transport proteins in carbohydrate assimilation,
distribution, metabolism, and homeostasis. Compr Physiol.
2:863–914. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Uldry M, Ibberson M, Hosokawa M and
Thorens B: GLUT2 is a high affinity glucosamine transporter. FEBS
Lett. 524:199–203. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Pouyssegur J, Marchiq I, Parks SK,
Durivault J, Zdralevic M and Vucetic M: ‘Warburg effect’ controls
tumor growth, bacterial, viral infections and immunity-Genetic
deconstruction and therapeutic perspectives. Semin Cancer Biol.
86((Pt 2)): 334–346. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Barron CC, Bilan PJ, Tsakiridis T and
Tsiani E: Facilitative glucose transporters: Implications for
cancer detection, prognosis and treatment. Metabolism. 65:124–139.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ancey PB, Contat C and Meylan E: Glucose
transporters in cancer - from tumor cells to the tumor
microenvironment. FEBS J. 285:2926–2943. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Pelicano H, Martin DS, Xu RH and Huang P:
Glycolysis inhibition for anticancer treatment. Oncogene.
25:4633–4646. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Wilson JE: Isozymes of mammalian
hexokinase: Structure, subcellular localization and metabolic
function. J Exp Biol. 206((Pt 12)): 2049–2057. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Guo D, Meng Y, Jiang X and Lu Z:
Hexokinases in cancer and other pathologies. Cell Insight.
2:1000772023. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Paredes F, Williams HC and San Martin A:
Metabolic adaptation in hypoxia and cancer. Cancer Lett.
502:133–142. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Denko NC: Hypoxia, HIF1 and glucose
metabolism in the solid tumour. Nat Rev Cancer. 8:705–713. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Iommarini L, Porcelli AM, Gasparre G and
Kurelac I: Non-canonical mechanisms regulating hypoxia-inducible
factor 1 alpha in cancer. Front Oncol. 7:2862017. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Maher JC, Wangpaichitr M, Savaraj N,
Kurtoglu M and Lampidis TJ: Hypoxia-inducible factor-1 confers
resistance to the glycolytic inhibitor 2-deoxy-D-glucose. Mol
Cancer Ther. 6:732–741. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Hsu CC, Tseng LM and Lee HC: Role of
mitochondrial dysfunction in cancer progression. Exp Biol Med
(Maywood). 241:1281–1295. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Zhang Y, Li Q, Huang Z, Li B, Nice EC,
Huang C, Wei L and Zou B: Targeting glucose metabolism enzymes in
cancer treatment: current and emerging strategies. Cancers (Basel).
14:45682022. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Yu G, Wang LG, Han Y and He QY:
clusterProfiler: An R package for comparing biological themes among
gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
R Core Team, . R: A language and
environment for statistical computing. R Foundation for Statistical
Computing; Vienna: 2024, http://www.R-project.org/
|
|
26
|
Luo W and Brouwer C: Pathview: An
R/Bioconductor package for pathway-based data integration and
visualization. Bioinformatics. 29:1830–1831. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Quastel JH and Cantero A: Inhibition of
tumour growth by D-glucosamine. Nature. 171:252–254. 1953.
View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Tamayo B, Kercher K, Vosburg C, Massimino
C, Jernigan MR, Hasan DL, Harper D, Mathew A, Adkins S, Shippy T,
et al: Annotation of glycolysis, gluconeogenesis, and
trehaloneogenesis pathways provide insight into carbohydrate
metabolism in the Asian citrus psyllid. GigaByte.
2022:gigabyte412022. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Suginohara T, Wakabayashi K, Ato S and
Ogasawara R: Effect of 2-deoxyglucose-mediated inhibition of
glycolysis on the regulation of mTOR signaling and protein
synthesis before and after high-intensity muscle contraction.
Metabolism. 114:1544192021. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Berthe A, Zaffino M, Muller C, Foulquier
F, Houdou M, Schulz C, Bost F, De Fay E, Mazerbourg S and Flament
S: Protein N-glycosylation alteration and glycolysis inhibition
both contribute to the antiproliferative action of 2-deoxyglucose
in breast cancer cells. Breast Cancer Res Treat. 171:581–591. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Bertoni JM and Weintraub ST: Competitive
inhibition of human brain hexokinase by metrizamide and related
compounds. J Neurochem. 42:513–518. 1984. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Tesoriere G, Vento R and Calvaruso G:
Inhibitory effect of D-glucosamine on glycolysis in bovine retina.
Biochim Biophys Acta. 385:58–67. 1975. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Marshall S, Yamasaki K and Okuyama R:
Glucosamine induces rapid desensitization of glucose transport in
isolated adipocytes by increasing GlcN-6-P levels. Biochem Biophys
Res Commun. 329:1155–1161. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Samizu M and Iida K: Glucosamine inhibits
the proliferation of hepatocellular carcinoma cells by eliciting
apoptosis, autophagy, and the anti-warburg effect. Scientifica
(Cairo). 2025:56858842025. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Jang BC, Sung SH, Park JG, Park JW, Bae
JH, Shin DH, Park GY, Han SB and Suh SI: Glucosamine hydrochloride
specifically inhibits COX-2 by preventing COX-2 N-glycosylation and
by increasing COX-2 protein turnover in a proteasome-dependent
manner. J Biol Chem. 282:27622–27632. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Kapoor K, Finer-Moore JS, Pedersen BP,
Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, Müller T,
Siebeneicher H and Stroud RM: Mechanism of inhibition of human
glucose transporter GLUT1 is conserved between cytochalasin B and
phenylalanine amides. Proc Natl Acad Sci USA. 113:4711–4716. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Wu CH, Ho YS, Tsai CY, Wang YJ, Tseng H,
Wei PL, Lee CH, Liu RS and Lin SY: In vitro and in vivo study of
phloretin-induced apoptosis in human liver cancer cells involving
inhibition of type II glucose transporter. Int J Cancer.
124:2210–2219. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Kapoor M, Mineau F, Fahmi H, Pelletier JP
and Martel-Pelletier J: Glucosamine sulfate reduces prostaglandin
E(2) production in osteoarthritic chondrocytes through inhibition
of microsomal PGE synthase-1. J Rheumatol. 39:635–644. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Sols A, De La Fuente G, Villarpalasi C and
Asensio C: Substrate specificity and some other properties of
baker's yeast hexokinase. Biochim Biophys Acta. 30:92–101. 1958.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Brown DH: The phosphorylation of D (+)
glucosamine by crystalline yeast hexokinase. Biochim Biophys Acta.
7:487–493. 1951. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Kuser PR, Krauchenco S, Antunes OA and
Polikarpov I: The high resolution crystal structure of yeast
hexokinase PII with the correct primary sequence provides new
insights into its mechanism of action. J Biol Chem.
275:20814–20821. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Chen YH and Cheng WH: Hexosamine
biosynthesis and related pathways, protein N-glycosylation and
O-GlcNAcylation: Their interconnection and role in plants. Front
Plant Sci. 15:13490642024. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Paneque A, Fortus H, Zheng J, Werlen G and
Jacinto E: The hexosamine biosynthesis pathway: Regulation and
function. Genes (Basel). 14:9932023. View Article : Google Scholar
|
|
44
|
Salazar J, Bello L, Chavez M, Anez R,
Rojas J and Bermudez V: Glucosamine for osteoarthritis: Biological
effects, clinical efficacy, and safety on glucose metabolism.
Arthritis. 2014:4324632014. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Robey RB and Hay N: Mitochondrial
hexokinases, novel mediators of the antiapoptotic effects of growth
factors and Akt. Oncogene. 25:4683–4696. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Xian H and Wang Y, Bao X, Zhang H, Wei F,
Song Y and Wang Y, Wei Y and Wang Y: Hexokinase inhibitor
2-deoxyglucose coordinates citrullination of vimentin and apoptosis
of fibroblast-like synoviocytes by inhibiting HK2/mTORC1-induced
autophagy. Int Immunopharmacol. 114:1095562023. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Rai Y, Yadav P, Kumari N, Kalra N and
Bhatt AN: Hexokinase II inhibition by 3-bromopyruvate sensitizes
myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin.
Biosci Rep. 39:BSR201908802019. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Thangaraju M, Karunakaran SK, Itagaki S,
Gopal E, Elangovan S, Prasad PD and Ganapathy V: Transport by
SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1)
and HDAC3 underlies the antitumor activity of 3-bromopyruvate.
Cancer. 115:4655–4666. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Paul S, Ghosh S and Kumar S: Tumor
glycolysis, an essential sweet tooth of tumor cells. Semin Cancer
Biol. 86((Pt 3)): 1216–1230. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Bose S, Zhang C and Le A: Glucose
metabolism in cancer: The warburg effect and beyond. Adv Exp Med
Biol. 1311:3–15. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Zhao J, Ma Y, Zhang Y, Fu B, Wu X, Li Q,
Cai G, Chen X and Bai XY: Low-dose 2-deoxyglucose and metformin
synergically inhibit proliferation of human polycystic kidney cells
by modulating glucose metabolism. Cell Death Discov. 5:762019.
View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Wang Z, Zhang L, Zhang D, Sun R, Wang Q
and Liu X: Glycolysis inhibitor 2-deoxy-D-glucose suppresses
carcinogen-induced rat hepatocarcinogenesis by restricting cancer
cell metabolism. Mol Med Rep. 11:1917–1924. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Medina RA and Owen GI: Glucose
transporters: Expression, regulation and cancer. Biol Res. 35:9–26.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Lehar J, Krueger AS, Avery W, Heilbut AM,
Johansen LM, Price ER, Rickles RJ, Short GF III, Staunton JE, Jin
X, et al: Synergistic drug combinations tend to improve
therapeutically relevant selectivity. Nat Biotechnol. 27:659–666.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Sadlecki P, Bodnar M, Grabiec M, Marszalek
A, Walentowicz P, Sokup A, Zegarska J and Walentowicz-Sadlecka M:
The role of Hypoxia-inducible factor-1 alpha, glucose
transporter-1, (GLUT-1) and carbon anhydrase IX in endometrial
cancer patients. Biomed Res Int. 2014:6168502014. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Wang P, Wan W, Xiong S, Wang J, Zou D, Lan
C, Yu S, Liao B, Feng H and Wu N: HIF1α regulates glioma
chemosensitivity through the transformation between differentiation
and dedifferentiation in various oxygen levels. Sci Rep.
7:79652017. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Sharma A, Sinha S and Shrivastava N:
Therapeutic targeting hypoxia-inducible factor (HIF-1) in cancer:
Cutting gordian knot of cancer cell metabolism. Front Genet.
13:8490402022. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Zhou J, Wu Z, Lin Z, Wang W, Wan R and Liu
T: Association between glucosamine use and cancer mortality: A
large prospective cohort study. Front Nutr. 9:9478182022.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Li ZH, Gao X, Chung VC, Zhong WF, Fu Q, Lv
YB, Wang ZH, Shen D, Zhang XR, Zhang PD, et al: Associations of
regular glucosamine use with all-cause and cause-specific
mortality: A large prospective cohort study. Ann Rheum Dis.
79:829–836. 2020. View Article : Google Scholar : PubMed/NCBI
|
