|
1
|
Lou XL, Sun J, Gong SQ, Yu XF, Gong R and
Deng H: Interaction between circulating cancer cells and platelets:
Clinical implication. Chin J Cancer Res. 27:450–460.
2015.PubMed/NCBI
|
|
2
|
Lawrence R, Watters M, Davies CR, Pantel K
and Lu YJ: Circulating tumour cells for early detection of
clinically relevant cancer. Nat Rev Clin Oncol. 20:487–500. 2023.
View Article : Google Scholar
|
|
3
|
Morris K, Schnoor B and Papa AL: Platelet
cancer cell interplay as a new therapeutic target. Biochim Biophys
Acta Rev Cancer. 1877:1887702022. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Sun Y, Li T, Ding L, Wang J, Chen C, Liu
T, Liu Y, Li Q, Wang C, Huo R, et al: Platelet-mediated circulating
tumor cell evasion from natural killer cell killing through immune
checkpoint CD155-TIGIT. Hepatology. 81:791–807. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Qi Y, Chen W, Liang X, Xu K, Gu X, Wu F,
Fan X, Ren S, Liu J, Zhang J, et al: Novel antibodies against GPIbα
inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. J
Hematol Oncol. 11:1172018. View Article : Google Scholar
|
|
6
|
Suzuki-Inoue K: Platelets and
cancer-associated thrombosis: Focusing on the platelet activation
receptor CLEC-2 and podoplanin. Blood. 134:1912–1918. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wang S, Li Z and Xu R: Human cancer and
platelet interaction, a potential therapeutic target. Int J Mol
Sci. 19:12462018. View Article : Google Scholar
|
|
8
|
Trousseau A: Lectures on clinical
medicine, delivered at the Hotel-Dieu, Paris, New Sydenham Society.
London: 1868
|
|
9
|
Ashworth TR: A case of cancer in which
cells similar to those in the tumours were seen in the blood after
death. Australas Med J. 14:146–147. 1869.
|
|
10
|
Billroth T: Metastatic tumours. Lectures
on surgical pathology and therapeutics. A handbook for students and
practitioners. The New Sydenham society; London: pp. 352–368.
1877
|
|
11
|
Levin J and Conley CL: Thrombocytosis
associated with malignant disease. Arch Intern Med. 114:497–500.
1964. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Gasic GJ, Gasic TB and Stewart CC:
Antimetastatic effects associated with platelet reduction. Proc
Natl Acad Sci USA. 61:46–52. 1968. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Gasic GJ, Gasic TB, Galanti N, Johnson T
and Murphy S: Platelet-tumor-cell interactions in mice. The role of
platelets in the spread of malignant disease. Int J Cancer.
11:704–718. 1973. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Nilsson RJA, Balaj L, Hulleman E, van Rijn
S, Pegtel DM, Walraven M, Widmark A, Gerritsen WR, Verheul HM,
Vandertop WP, et al: Blood platelets contain tumor-derived RNA
biomarkers. Blood. 118:3680–3683. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Kuznetsov HS, Marsh T, Markens BA, Castaño
Z, Greene-Colozzi A, Hay SA, Brown VE, Richardson AL, Signoretti S,
Battinelli EM and McAllister SS: Identification of luminal breast
cancers that establish a tumor-supportive macroenvironment defined
by proangiogenic platelets and bone marrow-derived cells. Cancer
Discov. 2:1150–1165. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Kerr BA, McCabe NP, Feng W and Byzova TV:
Platelets govern pre-metastatic tumor communication to bone.
Oncogene. 32:4319–4324. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Costantini V, Zacharski LR, Moritz TE and
Edwards RL: The platelet count in carcinoma of the lung and colon.
Thromb Haemost. 64:501–505. 1990. View Article : Google Scholar
|
|
18
|
Pedersen LM and Milman N: Prognostic
significance of thrombocytosis in patients with primary lung
cancer. Eur Respir J. 9:1826–1830. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Jiang X, Wong KHK, Khankhel AH, Zeinali M,
Reategui E, Phillips MJ, Luo X, Aceto N, Fachin F, Hoang AN, et al:
Microfluidic isolation of platelet-covered circulating tumor cells.
Lab Chip. 17:3498–3503. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Lim M, Park S, Jeong H, Park SH, Kumar S,
Jang A, Lee S, Kim DU and Cho Y: Circulating tumor cell clusters
are cloaked with platelets and correlate with poor prognosis in
unresectable pancreatic cancer. Cancers (Basel). 13:52722021.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Yang J, Xu P, Zhang G, Wang D, Ye B and Wu
L: Advances and potentials in platelet-circulating tumor cell
crosstalk. Am J Cancer Res. 15:407–425. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Erpenbeck L and Schön MP: Deadly allies:
The fatal interplay between platelets and metastasizing cancer
cells. Blood. 115:3427–3436. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Goh CY, Patmore S, Smolenski A, Howard J,
Evans S, O'Sullivan J and McCann A: The role of von Willebrand
factor in breast cancer metastasis. Transl Oncol. 14:1010332021.
View Article : Google Scholar
|
|
24
|
Kitagawa H, Yamamoto N, Yamamoto K, Tanoue
K, Kosaki G and Yamazaki H: Involvement of platelet membrane
glycoprotein Ib and glycoprotein IIb/IIIa complex in
thrombin-dependent and -independent platelet aggregations induced
by tumor cells. Cancer Res. 49:537–541. 1989.PubMed/NCBI
|
|
25
|
Lonsdorf AS, Krämer BF, Fahrleitner M,
Schönberger T, Gnerlich S, Ring S, Gehring S, Schneider SW, Kruhlak
MJ, Meuth SG, et al: Engagement of αIIbβ3 (GPIIb/IIIa) with ανβ3
integrin mediates interaction of melanoma cells with platelets: A
connection to hematogenous metastasis. J Biol Chem. 287:2168–2178.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Mammadova-Bach E, Gil-Pulido J,
Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D,
Remer K, Nurden P, Nurden AT, et al: Platelet glycoprotein VI
promotes metastasis through interaction with cancer cell-derived
galectin-3. Blood. 135:1146–1160. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Saha B, Mathur T, Tronolone JJ, Chokshi M,
Lokhande GK, Selahi A, Gaharwar AK, Afshar-Kharghan V, Sood AK, Bao
G and Jain A: Human tumor microenvironment chip evaluates the
consequences of platelet extravasation and combinatorial
antitumor-antiplatelet therapy in ovarian cancer. Sci Adv.
7:eabg52832021. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Eliceiri BP and Cheresh DA: The role of
alphav integrins during angiogenesis: Insights into potential
mechanisms of action and clinical development. J Clin Invest.
103:1227–1230. 1999. View Article : Google Scholar
|
|
29
|
Mammadova-Bach E, Zigrino P, Brucker C,
Bourdon C, Freund M, De Arcangelis A, Abrams SI, Orend G, Gachet C
and Mangin PH: Platelet integrin α 6 β 1 controls lung metastasis
through direct binding to cancer cell-derived ADAM9. JCI Insight.
1:e882452016. View Article : Google Scholar
|
|
30
|
Carpinteiro A, Becker KA, Japtok L,
Hessler G, Keitsch S, Požgajovà M, Schmid KW, Adams C, Müller S,
Kleuser B, et al: Regulation of hematogenous tumor metastasis by
acid sphingomyelinase. EMBO Mol Med. 7:714–734. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Carpinteiro A, Beckmann N, Seitz A,
Hessler G, Wilker B, Soddemann M, Helfrich I, Edelmann B, Gulbins E
and Becker KA: Role of acid sphingomyelinase-induced signaling in
melanoma cells for hematogenous tumor metastasis. Cell Physiol
Biochem. 38:1–14. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
McCarty OJ, Mousa SA, Bray PF and
Konstantopoulos K: Immobilized platelets support human colon
carcinoma cell tethering, rolling, and firm adhesion under dynamic
flow conditions. Blood. 96:1789–1797. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Shu L, Lin S, Zhou S and Yuan T:
Glycan-Lectin interactions between platelets and tumor cells drive
hematogenous metastasis. Platelets. 35:23150372024. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Egan K, Cooke N and Kenny D: Living in
shear: Platelets protect cancer cells from shear induced damage.
Clin Exp Metastasis. 31:697–704. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Nieswandt B, Hafner M, Echtenacher B and
Männel DN: Lysis of tumor cells by natural killer cells in mice is
impeded by platelets. Cancer Res. 59:1295–1300. 1999.PubMed/NCBI
|
|
36
|
Placke T, Kopp H and Salih HR: Modulation
of natural killer cell anti-tumor reactivity by platelets. J Innate
Immun. 3:374–382. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Anvari S, Osei E and Maftoon N:
Interactions of platelets with circulating tumor cells contribute
to cancer metastasis. Sci Rep. 11:154772021. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Fabricius HÅ, Starzonek S and Lange T: The
role of platelet cell surface P-selectin for the direct
platelet-tumor cell contact during metastasis formation in human
tumors. Front Oncol. 11:6427612021. View Article : Google Scholar
|
|
39
|
Ling T and Liu J, Dong L and Liu J: The
roles of P-selectin in cancer cachexia. Med Oncol. 40:3382023.
View Article : Google Scholar
|
|
40
|
Liu Y, Zhao F, Gu W, Yang H, Meng Q, Zhang
Y, Yang H and Duan Q: The roles of platelet GPIIb/IIIa and
alphavbeta3 integrins during HeLa cells adhesion, migration, and
invasion to monolayer endothelium under static and dynamic shear
flow. J Biomed Biotechnol. 2009:8292432009. View Article : Google Scholar
|
|
41
|
Schlesinger M: Role of platelets and
platelet receptors in cancer metastasis. J Hematol Oncol.
11:1252018. View Article : Google Scholar
|
|
42
|
Ren J, He J, Zhang H, Xia Y, Hu Z,
Loughran P, Billiar T, Huang H and Tsung A: Platelet TLR4-ERK5 axis
facilitates NET-mediated capturing of circulating tumor cells and
distant metastasis after surgical stress. Cancer Res. 81:2373–2385.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Cui H, Tan YX, Österholm C, Zhang X, Hedin
U, Vlodavsky I and Li JP: Heparanase expression upregulates
platelet adhesion activity and thrombogenicity. Oncotarget.
7:39486–39496. 2016. View Article : Google Scholar
|
|
44
|
Li H, Yu Y, Gao L, Zheng P, Liu X and Chen
H: Tissue factor: A neglected role in cancer biology. J Thromb
Thrombolysis. 54:97–108. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Deryugina EI and Quigley JP: Matrix
metalloproteinases and tumor metastasis. Cancer Metastasis Rev.
25:9–34. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Labelle M, Begum S and Hynes RO: Direct
signaling between platelets and cancer cells induces an
epithelial-mesenchymal-like transition and promotes metastasis.
Cancer Cell. 20:576–590. 2011. View Article : Google Scholar
|
|
47
|
Medina VA and Rivera ES: Histamine
receptors and cancer pharmacology. Br J Pharmacol. 161:755–767.
2010. View Article : Google Scholar
|
|
48
|
Schumacher D, Strilic B, Sivaraj KK,
Wettschureck N and Offermanns S: Platelet-derived nucleotides
promote tumor-cell transendothelial migration and metastasis via
P2Y2 receptor. Cancer Cell. 24:130–137. 2013. View Article : Google Scholar
|
|
49
|
Skolnik G, Bagge U, Blomqvist G, Djärv L
and Ahlman H: The role of calcium channels and serotonin (5-HT2)
receptors for tumour cell lodgement in the liver. Clin Exp
Metastasis. 7:169–174. 1989. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Zhong C, Wang W, Yao Y, Lian S, Xie X, Xu
J, He S, Luo L, Ye Z, Zhang J, et al: TGF-β secreted by cancer
cells-platelets interaction activates cancer metastasis potential
by inducing metabolic reprogramming and bioenergetic adaptation. J
Cancer. 16:1310–1323. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Tong H, Li K, Zhou M, Wu R, Yang H, Peng
Z, Zhao Q and Luo KQ: Coculture of cancer cells with platelets
increases their survival and metastasis by activating the
TGFβ/Smad/PAI-1 and PI3K/AKT pathways. Int J Biol Sci.
19:4259–4277. 2023. View Article : Google Scholar
|
|
52
|
Eslami-S Z, Cortés-Hernández LE,
Glogovitis I, Antunes-Ferreira M, D Ambrosi S, Kurma K, Garima F,
Cayrefourcq L, Best MG, Koppers-Lalic D, et al: In vitro cross-talk
between metastasis-competent circulating tumor cells and platelets
in colon cancer: A malicious association during the harsh journey
in the blood. Front Cell Dev Biol. 11:12098462023. View Article : Google Scholar
|
|
53
|
Filippelli A, Del Gaudio C, Simonis V,
Ciccone V, Spini A and Donnini S: Scoping review on platelets and
tumor angiogenesis: Do we need more evidence or better analysis?
Int J Mol Sci. 23:134012022. View Article : Google Scholar
|
|
54
|
Ghosh LD, Mathur T, Tronolone JJ, Chuong
A, Rangel K, Corvigno S, Sood AK and Jain A: Angiogenesis-enabled
human ovarian tumor microenvironment-chip evaluates pathophysiology
of platelets in microcirculation. Adv Healthc Mater.
13:e23042632024. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Gleissner CA: Platelet-derived chemokines
in atherogenesis: What's new? Curr Vasc Pharmacol. 10:563–569.
2012. View Article : Google Scholar
|
|
56
|
Labelle M, Begum S and Hynes RO: Platelets
guide the formation of early metastatic niches. Proc Natl Acad Sci
USA. 111:E3053–E3061. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Wang X, Zhao S, Wang Z and Gao T:
Platelets involved tumor cell EMT during circulation:
Communications and interventions. Cell Commun Signal. 20:822022.
View Article : Google Scholar
|
|
58
|
Chen J, Yuan W, Wu L, Tang Q, Xia Q, Ji J,
Liu Z, Ma Z, Zhou Z, Cheng Y and Shu X: PDGF-D promotes cell
growth, aggressiveness, angiogenesis and EMT transformation of
colorectal cancer by activation of Notch1/Twist1 pathway.
Oncotarget. 8:9961–9973. 2017. View Article : Google Scholar
|
|
59
|
Zhang H, Sun JD, Yan LJ and Zhao XP:
PDGF-D/PDGFRβ promotes tongue squamous carcinoma cell (TSCC)
progression via activating p38/AKT/ERK/EMT signal pathway. Biochem
Biophys Res Commun. 478:845–851. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Takagi S, Sasaki Y, Koike S, Takemoto A,
Seto Y, Haraguchi M, Ukaji T, Kawaguchi T, Sugawara M, Saito M, et
al: Platelet-derived lysophosphatidic acid mediated LPAR1
activation as a therapeutic target for osteosarcoma metastasis.
Oncogene. 40:5548–5558. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Plantureux L, Mège D, Crescence L,
Carminita E, Robert S, Cointe S, Brouilly N, Ezzedine W,
Dignat-George F, Dubois C and Panicot-Dubois L: The interaction of
platelets with colorectal cancer cells inhibits tumor growth but
promotes metastasis. Cancer Res. 80:291–303. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Li W, Liu JB, Hou LK, Yu F, Zhang J, Wu W,
Tang XM, Sun F, Lu HM, Deng J, et al: Liquid biopsy in lung cancer:
Significance in diagnostics, prediction, and treatment monitoring.
Mol Cancer. 21:252022. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Murphy L, Inchauspé J, Valenzano G,
Holland P, Sousos N, Belnoue-Davis HL, Li R, Jooss NJ, Benlabiod C,
Murphy E, et al: Platelets sequester extracellular DNA, capturing
tumor-derived and free fetal DNA. Science. 389:eadp39712025.
View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Roweth HG and Battinelli EM: Lessons to
learn from tumor-educated platelets. Blood. 137:3174–3180. 2021.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Best MG, Wesseling P and Wurdinger T:
Tumor-educated platelets as a noninvasive biomarker source for
cancer detection and progression monitoring. Cancer Res.
78:3407–3412. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Strasenburg W, Jóźwicki J, Durślewicz J,
Kuffel B, Kulczyk MP, Kowalewski A, Grzanka D, Drewa T and
Adamowicz J: Tumor cell-induced platelet aggregation as an emerging
therapeutic target for cancer therapy. Front Oncol. 12:9097672022.
View Article : Google Scholar
|
|
67
|
Ding S, Dong X and Song X: Tumor educated
platelet: The novel biosource for cancer detection. Cancer Cell
Int. 23:912023. View Article : Google Scholar
|
|
68
|
Amirkhosravi A, Amaya M, Desai H and
Francis JL: Platelet-CD40 ligand interaction with melanoma cell and
monocyte CD40 enhances cellular procoagulant activity. Blood Coagul
Fibrinolysis. 13:505–512. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Mezouar S, Darbousset R, Dignat-George F,
Panicot-Dubois L and Dubois C: Inhibition of platelet activation
prevents the P-selectin and integrin-dependent accumulation of
cancer cell microparticles and reduces tumor growth and metastasis
in vivo. Int J Cancer. 136:462–475. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Miyazaki M, Nakabo A, Nagano Y, Nagamura
Y, Yanagihara K, Ohki R, Nakamura Y, Fukami K, Kawamoto J,
Umayahara K, et al: Tissue factor-induced fibrinogenesis mediates
cancer cell clustering and multiclonal peritoneal metastasis.
Cancer Lett. 553:2159832023. View Article : Google Scholar
|
|
71
|
Zhang Y, Li Z, Zhang J, Mafa T, Zhang J,
Zhu H, Chen L, Zong Z and Yang L: Fibrinogen: A new player and
target on the formation of pre-metastatic niche in tumor
metastasis. Crit Rev Oncol Hematol. 207:1046252025. View Article : Google Scholar
|
|
72
|
Catani MV, Savini I, Tullio V and Gasperi
V: The ‘janus face’ of platelets in cancer. Int J Mol Sci.
21:7882020. View Article : Google Scholar
|
|
73
|
Allegra A, Cancemi G, Mirabile G, Tonacci
A, Musolino C and Gangemi S: Circulating tumour cells, cell free
DNA and tumour-educated platelets as reliable prognostic and
management biomarkers for the liquid biopsy in multiple myeloma.
Cancers (Basel). 14:41362022. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Feng W, Jia N, Jiao H, Chen J, Chen Y,
Zhang Y, Zhu M, Zhu C, Shen L and Long W: Circulating tumor DNA as
a prognostic marker in high-risk endometrial cancer. J Transl Med.
19:512021. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Hu H, Song H, Han B, Zhao H and He J:
Tumor-educated platelet RNA and circulating free RNA: Emerging
liquid biopsy markers for different tumor types. Front Biosci
(Landmark Ed). 29:802024. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Pereira-Veiga T, Martínez-Fernández M,
Abuin C, Piñeiro R, Cebey V, Cueva J, Palacios P, Blanco C,
Muinelo-Romay L, Abalo A, et al: CTCs expression profiling for
advanced breast cancer monitoring. Cancers (Basel). 11:19412019.
View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Li TT, Liu H, Yu J, Shi GY, Zhao LY and Li
GX: Prognostic and predictive blood biomarkers in gastric cancer
and the potential application of circulating tumor cells. World J
Gastroenterol. 24:2236–2246. 2018. View Article : Google Scholar
|
|
78
|
Haemmerle M, Stone RL, Menter DG,
Afshar-Kharghan V and Sood AK: The platelet lifeline to cancer:
Challenges and opportunities. Cancer Cell. 33:965–983. 2018.
View Article : Google Scholar
|
|
79
|
Gao L, Zhang H, Zhang B, Zhang L and Wang
C: Prognostic value of combination of preoperative platelet count
and mean platelet volume in patients with resectable non-small cell
lung cancer. Oncotarget. 8:15632–15641. 2017. View Article : Google Scholar
|
|
80
|
Mandaliya H, Jones M, Oldmeadow C and
Nordman IIC: Prognostic biomarkers in stage IV non-small cell lung
cancer (NSCLC): Neutrophil to lymphocyte ratio (NLR), lymphocyte to
monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and
advanced lung cancer inflammation index (ALI). Transl Lung Cancer
Res. 8:886–894. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Palacios-Acedo AL, Mège D, Crescence L,
Dignat-George F, Dubois C and Panicot-Dubois L: Platelets,
thrombo-inflammation, and cancer: Collaborating with the enemy.
Front Immunol. 10:18052019. View Article : Google Scholar
|
|
82
|
Kobayashi S, Sugasaki A, Yamamoto Y,
Shigenoi Y, Udaka A, Yamamoto A and Tanaka M: Enrichment of cancer
cells based on antibody-free selective cell adhesion. ACS Biomater
Sci Eng. 8:4547–4556. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Ma Y, Zhang J, Tian Y, Fu Y, Tian S, Li Q,
Yang J and Zhang L: Zwitterionic microgel preservation platform for
circulating tumor cells in whole blood specimen. Nat Commun.
14:49582023. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
Plantureux L, Mège D, Crescence L,
Dignat-George F, Dubois C and Panicot-Dubois L: Impacts of cancer
on platelet production, activation and education and mechanisms of
cancer-associated thrombosis. Cancers (Basel). 10:4412018.
View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Best MG, Sol N, Kooi I, Tannous J,
Westerman BA, Rustenburg F, Schellen P, Verschueren H, Post E,
Koster J, et al: RNA-seq of tumor-educated platelets enables
blood-based pan-cancer, multiclass, and molecular pathway cancer
diagnostics. Cancer Cell. 28:666–676. 2015. View Article : Google Scholar
|
|
86
|
D'Ambrosi S, Nilsson RJ and Wurdinger T:
Platelets and tumor-associated RNA transfer. Blood. 137:3181–3191.
2021. View Article : Google Scholar
|
|
87
|
Heinhuis KM, In't Veld SGJG, Dwarshuis G,
van den Broek D, Sol N, Best MG, Coevorden FV, Haas RL, Beijnen JH,
van Houdt WJ, et al: RNA-sequencing of tumor-educated platelets, a
novel biomarker for blood-based sarcoma diagnostics. Cancers
(Basel). 12:13722020. View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Antunes-Ferreira M, D Ambrosi S, Arkani M,
Post E, In't Veld SGJG, Ramaker J, Zwaan K, Kucukguzel ED, Wedekind
LE, Griffioen AW, et al: Tumor-educated platelet blood tests for
non-small cell lung cancer detection and management. Sci Rep.
13:93592023. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Gao Y, Liu CJ, Li HY, Xiong XM, Li GL,
In't Veld SGJG, Cai GY, Xie GY, Zeng SQ, Wu Y, et al: Platelet RNA
enables accurate detection of ovarian cancer: An intercontinental,
biomarker identification study. Protein Cell. 14:579–590. 2023.
|
|
90
|
Sol N, In't Veld SGJG, Vancura A,
Tjerkstra M, Leurs C, Rustenburg F, Schellen P, Verschueren H, Post
E, Zwaan K, et al: Tumor-educated platelet RNA for the detection
and (pseudo)progression monitoring of glioblastoma. Cell Rep Med.
1:1001012020. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Mantini G, Meijer LL, Glogovitis I, In't
Veld SGJG, Paleckyte R, Capula M, Le Large TYS, Morelli L, Pham TV,
Piersma SR, et al: Omics analysis of educated platelets in cancer
and benign disease of the pancreas. Cancers (Basel). 13:662020.
View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Łukasiewicz M, Pastuszak K,
Łapińska-Szumczyk S, Różański R, Veld SGJG, Bieńkowski M, Stokowy
T, Ratajska M, Best MG, Würdinger T, et al: Diagnostic accuracy of
liquid biopsy in endometrial cancer. Cancers (Basel).
13:57312021.
|
|
93
|
Dong X, Ding S, Yu M, Niu L, Xue L, Zhao
Y, Xie L and Song X and Song X: Small nuclear RNAs (U1, U2, U5) in
tumor-educated platelets are downregulated and act as promising
biomarkers in lung cancer. Front Oncol. 10:16272020. View Article : Google Scholar
|
|
94
|
Xu L, Li X, Li X, Wang X, Ma Q, She D, Lu
X, Zhang J, Yang Q, Lei S, et al: RNA profiling of blood platelets
noninvasively differentiates colorectal cancer from healthy donors
and noncancerous intestinal diseases: A retrospective cohort study.
Genome Med. 14:262022. View Article : Google Scholar : PubMed/NCBI
|
|
95
|
In't Veld SGJG, Arkani M, Post E,
Antunes-Ferreira M, D'Ambrosi S, Vessies DCL, Vermunt L, Vancura A,
Muller M, Niemeijer AN, et al: Detection and localization of early-
and late-stage cancers using platelet RNA. Cancer Cell.
40:999–1009.e6. 2022. View Article : Google Scholar
|
|
96
|
Xiao R, Liu C, Zhang B and Ma L:
Tumor-educated platelets as a promising biomarker for blood-based
detection of renal cell carcinoma. Front Oncol. 12:8445202022.
View Article : Google Scholar
|
|
97
|
Lomnytska M, Pinto R, Becker S, Engström
U, Gustafsson S, Björklund C, Templin M, Bergstrand J, Xu L,
Widengren J, et al: Platelet protein biomarker panel for ovarian
cancer diagnosis. Biomark Res. 6:22018. View Article : Google Scholar : PubMed/NCBI
|
|
98
|
Sabrkhany S, Kuijpers MJE, Knol JC, Olde
Damink SWM, Dingemans AC, Verheul HM, Piersma SR, Pham TV,
Griffioen AW, Oude Egbrink MGA and Jimenez CR: Exploration of the
platelet proteome in patients with early-stage cancer. J
Proteomics. 177:65–74. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Tao DL, Tassi Yunga S, Williams CD and
McCarty OJT: Aspirin and antiplatelet treatments in cancer. Blood.
137:3201–3211. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
100
|
Johnson KE, Ceglowski JR, Roweth HG,
Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW,
Machlus KR, Chen WY, et al: Aspirin inhibits platelets from
reprogramming breast tumor cells and promoting metastasis. Blood
Adv. 3:198–211. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
101
|
McCarty MF and Block KI: Preadministration
of high-dose salicylates, suppressors of NF-kappaB activation, may
increase the chemosensitivity of many cancers: An example of
proapoptotic signal modulation therapy. Integr Cancer Ther.
5:252–268. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Chan AT and Ladabaum U: Where do we stand
with aspirin for the prevention of colorectal cancer? The USPSTF
recommendations. Gastroenterology. 150:14–18. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Chubak J, Whitlock EP, Williams SB,
Kamineni A, Burda BU, Buist DSM and Anderson ML: Aspirin for the
prevention of cancer incidence and mortality: Systematic evidence
reviews for the U.S. Preventive services task force. Ann Intern
Med. 164:814–825. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Bruno A, Dovizio M, Tacconelli S, Contursi
A, Ballerini P and Patrignani P: Antithrombotic agents and cancer.
Cancers (Basel). 10:2532018. View Article : Google Scholar : PubMed/NCBI
|
|
105
|
Cho MS, Noh K, Haemmerle M, Li D, Park H,
Hu Q, Hisamatsu T, Mitamura T, Mak SLC, Kunapuli S, et al: Role of
ADP receptors on platelets in the growth of ovarian cancer. Blood.
130:1235–1242. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Guillem-Llobat P, Dovizio M, Bruno A,
Ricciotti E, Cufino V, Sacco A, Grande R, Alberti S, Arena V,
Cirillo M, et al: Aspirin prevents colorectal cancer metastasis in
mice by splitting the crosstalk between platelets and tumor cells.
Oncotarget. 7:32462–32477. 2016. View Article : Google Scholar
|
|
107
|
Xu XR, Yousef GM and Ni H: Cancer and
platelet crosstalk: Opportunities and challenges for aspirin and
other antiplatelet agents. Blood. 131:1777–1789. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Zhang C, Liu Y, Gao Y, Shen J, Zheng S,
Wei M and Zeng X: Modified heparins inhibit integrin
alpha(IIb)beta(3) mediated adhesion of melanoma cells to platelets
in vitro and in vivo. Int J Cancer. 125:2058–2065. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Kononczuk J, Surazynski A, Czyzewska U,
Prokop I, Tomczyk M, Palka J and Miltyk W: αIIbβ3-integrin ligands:
Abciximab and eptifibatide as proapoptotic factors in MCF-7 human
breast cancer cells. Curr Drug Targets. 16:1429–1437. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Yap ML, McFadyen JD, Wang X, Zia NA,
Hohmann JD, Ziegler M, Yao Y, Pham A, Harris M, Donnelly PS, et al:
Targeting activated platelets: A unique and potentially universal
approach for cancer imaging. Theranostics. 7:2565–2574. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Yap ML, McFadyen JD, Wang X, Ziegler M,
Chen YC, Willcox A, Nowell CJ, Scott AM, Sloan EK, Hogarth PM, et
al: Activated platelets in the tumor microenvironment for targeting
of antibody-drug conjugates to tumors and metastases. Theranostics.
9:1154–1169. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Dovizio M, Maier TJ, Alberti S, Di
Francesco L, Marcantoni E, Münch G, John CM, Suess B, Sgambato A,
Steinhilber D, et al: Pharmacological inhibition of platelet-tumor
cell cross-talk prevents platelet-induced overexpression of
cyclooxygenase-2 in HT29 human colon carcinoma cells. Mol
Pharmacol. 84:25–40. 2013. View Article : Google Scholar
|
|
113
|
Tsai HJ, Cheng KW, Li JC, Ruan TX, Chang
TH, Wang JR and Tseng CP: Identification of podoplanin aptamers by
SELEX for protein detection and inhibition of platelet aggregation
stimulated by C-type lectin-like receptor 2. Biosensors (Basel).
14:4642024. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Erpenbeck L, Nieswandt B, Schön M,
Pozgajova M and Schön MP: Inhibition of platelet GPIb alpha and
promotion of melanoma metastasis. J Invest Dermatol. 130:576–586.
2010. View Article : Google Scholar
|
|
115
|
Xu P, Zuo H, Chen B, Wang R, Ahmed A, Hu Y
and Ouyang J: Doxorubicin-loaded platelets as a smart drug delivery
system: An improved therapy for lymphoma. Sci Rep. 7:426322017.
View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Zhao J, Ye H, Lu Q, Wang K, Chen X, Song
J, Wang H, Lu Y, Cheng M, He Z, et al: Inhibition of post-surgery
tumour recurrence via a sprayable chemo-immunotherapy gel releasing
PD-L1 antibody and platelet-derived small EVs. J Nanobiotechnology.
20:622022. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Schnoor B, Morris K, Kottana RK, Muldoon
R, Barron J and Papa AL: Fibrinolytic platelet decoys reduce cancer
metastasis by dissociating circulating tumor cell clusters. Adv
Healthc Mater. 13:e23043742024. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Li J, Sharkey CC, Wun B, Liesveld JL and
King MR: Genetic engineering of platelets to neutralize circulating
tumor cells. J Control Release. 228:38–47. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Wang C, Sun W, Ye Y, Hu Q, Bomba HN and Gu
Z: In situ activation of platelets with checkpoint inhibitors for
post-surgical cancer immunotherapy. Nat Biomed Eng. 1:00112017.
View Article : Google Scholar
|
|
120
|
Hu Q, Li H, Archibong E, Chen Q, Ruan H,
Ahn S, Dukhovlinova E, Kang Y, Wen D, Dotti G and Gu Z: Inhibition
of post-surgery tumour recurrence via a hydrogel releasing CAR-T
cells and anti-PDL1-conjugated platelets. Nat Biomed Eng.
5:1038–1047. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Yang Y, Wang Y, Yao Y, Wang S, Zhang Y,
Dotti G, Yu J and Gu Z: T cell-mimicking platelet-drug conjugates.
Matter. 6:2340–2355. 2023. View Article : Google Scholar
|
|
122
|
Chen M, Wang P, Jiang D, Bao Z and Quan H:
Platelet membranes coated gold nanocages for tumor targeted drug
delivery and amplificated low-dose radiotherapy. Front Oncol.
11:7930062021. View Article : Google Scholar
|
|
123
|
Xia D, Hang D, Li Y, Jiang W, Zhu J, Ding
Y, Gu H and Hu Y: Au-hemoglobin loaded platelet alleviating tumor
hypoxia and enhancing the radiotherapy effect with low-dose X-ray.
ACS Nano. 14:15654–15668. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Sim X, Poncz M, Gadue P and French DL:
Understanding platelet generation from megakaryocytes: Implications
for in vitro-derived platelets. Blood. 127:1227–1233. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
125
|
Zhou Z, Zhang B, Zai W, Kang L, Yuan A, Hu
Y and Wu J: Perfluorocarbon nanoparticle-mediated platelet
inhibition promotes intratumoral infiltration of T cells and boosts
immunotherapy. Proc Natl Acad Sci USA. 116:11972–11977. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Ke Y, Ma Z, Ye H, Guan X, Xiang Z, Xia Y
and Shi Q: Chlorogenic acid-conjugated nanoparticles suppression of
platelet activation and disruption to tumor vascular barriers for
enhancing drug penetration in tumor. Adv Healthc Mater.
12:22022052023. View Article : Google Scholar
|
|
127
|
Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu
Q, Wun B, Roy S, Shen X and King MR: Targeted drug delivery to
circulating tumor cells via platelet membrane-functionalized
particles. Biomaterials. 76:52–65. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Liu R, Xu B, Ma Z, Ye H, Guan X, Ke Y,
Xiang Z and Shi Q: Controlled release of nitric oxide for enhanced
tumor drug delivery and reduction of thrombosis risk. RSC Adv.
12:32355–32364. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Li S, Zhang Y, Wang J, Zhao Y, Ji T, Zhao
X, Ding Y, Zhao X, Zhao R, Li F, et al: Nanoparticle-mediated local
depletion of tumour-associated platelets disrupts vascular barriers
and augments drug accumulation in tumours. Nat Biomed Eng.
1:667–679. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
Luo S, Feng J, Xiao L, Guo L, Deng L, Du
Z, Xue Y, Song X, Sun X, Zhang Z, et al: Targeting self-assembly
peptide for inhibiting breast tumor progression and metastasis.
Biomaterials. 249:1200552020. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Dhandapani R, Sethuraman S, Krishnan UM
and Subramanian A: Self-assembled multifunctional nanotheranostics
against circulating tumor clusters in metastatic breast cancer.
Acta Pharm Sin B. 13:1711–1725. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
132
|
Smit DJ, Pantel K and Jücker M:
Circulating tumor cells as a promising target for individualized
drug susceptibility tests in cancer therapy. Biochem Pharmacol.
188:1145892021. View Article : Google Scholar
|