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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
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|
Britt KL, Cuzick J and Phillips KA: Key steps for effective breast cancer prevention. Nat Rev Cancer. 20:417–436. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Admoun C and Mayrovitz HN: The etiology of breast cancer. Mayrovitz HN: Breast Cancer [Internet] Brisbane (AU): Exon Publications; 2022, View Article : Google Scholar | |
|
Youn HJ and Han W: A review of the epidemiology of breast cancer in Asia: Focus on risk factors. Asian Pac J Cancer Prev. 21:867–880. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ligibel JA, Ballman KV, McCall L, Goodwin PJ, Alfano CM, Bernstein V, Crane TE, Delahanty LM, Frank E, Hahn O, et al: Impact of a weight loss intervention on 1-year weight change in women with stage II/III breast cancer: Secondary analysis of the breast cancer weight loss (BWEL) trial. JAMA Oncol. 11:1194–1203. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Bellanger M, Lima SM, Cowppli-Bony A, Molinié F and Terry MB: Effects of fertility on breast cancer incidence trends: Comparing France and US. Cancer Causes Control. 32:903–910. 2021.PubMed/NCBI | |
|
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024.PubMed/NCBI | |
|
Herdiana Y, Sriwidodo S, Sofian FF, Wilar G and Diantini A: Nanoparticle-based antioxidants in stress signaling and programmed cell death in breast cancer treatment. Molecules. 28:53052023. View Article : Google Scholar : PubMed/NCBI | |
|
Propper DJ and Balkwill FR: Harnessing cytokines and chemokines for cancer therapy. Nat Rev Clin Oncol. 19:237–253. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Ruggieri L, Moretti A, Berardi R, Cona MS, Dalu D, Villa C, Chizzoniti D, Piva S, Gambaro A and La Verde N: Host-related factors in the interplay among inflammation, immunity and dormancy in breast cancer recurrence and prognosis: An overview for clinicians. Int J Mol Sci. 24:49742023. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Yu R, Cai T, Chen Z, Lan M, Zou T, Wang B, Wang Q, Zhao Y and Cai Y: Effects of immune cells and cytokines on inflammation and immunosuppression in the tumor microenvironment. Int Immunopharmacol. 88:1069392020. View Article : Google Scholar : PubMed/NCBI | |
|
Habanjar O, Bingula R, Decombat C, Diab-Assaf M, Caldefie-Chezet F and Delort L: Crosstalk of inflammatory cytokines within the breast tumor microenvironment. Int J Mol Sci. 24:40022023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X and Zhao L: Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9:7204–7218. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yu L, Abd Ghani MK, Aghemo A, Barh D, Bassetti M, Catena F, Gallo G, Gholamrezanezhad A, Kamal MA, Lal A, et al: SARS-CoV-2 infection, inflammation, immunonutrition, and pathogenesis of COVID-19. Curr Med Chem. 30:4390–4408. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Y, Li X, Yang M and Liu SB: Research progress on morphology and mechanism of programmed cell death. Cell Death Dis. 15:3272024. View Article : Google Scholar : PubMed/NCBI | |
|
Della Torre L, Beato A, Capone V, Carannante D, Verrilli G, Favale G, Del Gaudio N, Megchelenbrink WL, Benedetti R, Altucci L and Carafa V: Involvement of regulated cell deaths in aging and age-related pathologies. Ageing Res Rev. 95:1022512024. View Article : Google Scholar : PubMed/NCBI | |
|
Fernández-Lázaro D, Sanz B and Seco-Calvo J: The mechanisms of regulated cell death: Structural and functional proteomic pathways induced or inhibited by a specific protein-A narrative review. Proteomes. 12:32024. View Article : Google Scholar : PubMed/NCBI | |
|
Qian S, Long Y, Tan G, Li X, Xiang B, Tao Y, Xie Z and Zhang X: Programmed cell death: Molecular mechanisms, biological functions, diseases, and therapeutic targets. MedComm (2020). 5:e700242024. View Article : Google Scholar : PubMed/NCBI | |
|
Tong X, Tang R, Xiao M, Xu J, Wang W, Zhang B, Liu J, Yu X and Shi S: Targeting cell death pathways for cancer therapy: Recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research. J Hematol Oncol. 15:1742022. View Article : Google Scholar : PubMed/NCBI | |
|
He R, Liu Y, Fu W, He X, Liu S, Xiao D and Tao Y: Mechanisms and cross-talk of regulated cell death and their epigenetic modifications in tumor progression. Mol Cancer. 23:2672024. View Article : Google Scholar : PubMed/NCBI | |
|
Nagata S: Apoptosis and clearance of apoptotic cells. Annu Rev Immunol. 36:489–517. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Patel AA, Ginhoux F and Yona S: Monocytes, macrophages, dendritic cells and neutrophils: An update on lifespan kinetics in health and disease. Immunology. 163:250–261. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Upton JW, Shubina M and Balachandran S: RIPK3-driven cell death during virus infections. Immunol Rev. 277:90–101. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yu L: Cell self-destruction (programmed cell death), immunonutrition and metabolism. Biology (Basel). 12:9492023.PubMed/NCBI | |
|
Santagostino SF, Assenmacher CA, Tarrant JC, Adedeji AO and Radaelli E: Mechanisms of regulated cell death: Current perspectives. Vet Pathol. 58:596–623. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Jorgensen I, Rayamajhi M and Miao EA: Programmed cell death as a defence against infection. Nat Rev Immunol. 17:151–164. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Bekkering S, Domínguez-Andrés J, Joosten LAB, Riksen NP and Netea MG: Trained immunity: Reprogramming innate immunity in health and disease. Annu Rev Immunol. 39:667–693. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, Liu S, Goraya MU, Maarouf M, Huang S and Chen JL: Host immune response to influenza A virus infection. Front Immunol. 9:3202018. View Article : Google Scholar : PubMed/NCBI | |
|
Purnamasari S and Hidayat R: The role of natural physical, mechanical, and biochemical barriers as innate immunity: A narrative literature review. Open Access Indones J Med Rev. 3:361–364. 2023. | |
|
Place DE and Kanneganti TD: The innate immune system and cell death in autoinflammatory and autoimmune disease. Curr Opin Immunol. 67:95–105. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Molfetta R, Quatrini L, Santoni A and Paolini R: Regulation of NKG2D-dependent NK cell functions: The Yin and the Yang of receptor endocytosis. Int J Mol Sci. 18:16772017. View Article : Google Scholar : PubMed/NCBI | |
|
Ren X, Peng M, Xing P, Wei Y, Galbo PM Jr, Corrigan D, Wang H, Su Y, Dong X, Sun Q, et al: Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell-mediated antitumor immunity. J Clin Invest. 132:e1636202022. View Article : Google Scholar : PubMed/NCBI | |
|
Paolini R and Molfetta R: Dysregulation of DNAM-1-mediated NK cell anti-cancer responses in the tumor microenvironment. Cancers (Basel). 15:46162023. View Article : Google Scholar : PubMed/NCBI | |
|
Voskoboinik I, Whisstock JC and Trapani JA: Perforin and granzymes: Function, dysfunction and human pathology. Nat Rev Immunol. 15:388–400. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lin W, Luo Y, Wu J, Zhang H, Jin G, Guo C, Zhou H, Liang H and Xu X: Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment. J Immunother Cancer. 11:e0074022023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Liu G, Li Y and Pan Y: Metabolic reprogramming induces macrophage polarization in the tumor microenvironment. Front Immunol. 13:8400292022. View Article : Google Scholar : PubMed/NCBI | |
|
Boada-Romero E, Martinez J, Heckmann BL and Green DR: The clearance of dead cells by efferocytosis. Nat Rev Mol Cell Biol. 21:398–414. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Telser AG: Molecular biology of the cell, 4th edition. Shock. 18:2892002. View Article : Google Scholar | |
|
Li D and Wu M: Pattern recognition receptors in health and diseases. Signal Transduct Target Ther. 6:2912021. View Article : Google Scholar : PubMed/NCBI | |
|
Koike A, Tsujinaka K and Fujimori K: Statins attenuate antiviral IFN-β and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages. FEBS J. 288:4249–4266. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Turner MD, Nedjai B, Hurst T and Pennington DJ: Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta. 1843:2563–2582. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ivashkiv LB and Donlin LT: Regulation of type I interferon responses. Nat Rev Immunol. 14:36–49. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Li G, Zhao X, Zheng Z, Zhang H, Wu Y, Shen Y and Chen Q: cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors. Cell Mol Life Sci. 81:1492024. View Article : Google Scholar : PubMed/NCBI | |
|
Dong H, Franklin NA, Ritchea SB, Yagita H, Glennie MJ and Bullock TN: CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses. Eur J Immunol. 45:3289–3301. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jo EK, Kim JK, Shin DM and Sasakawa C: Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 13:148–159. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng M and Kanneganti TD: The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunol Rev. 297:26–38. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F and Shao F: Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 526:660–665. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Tengesdal IW, Li S, Powers NE, May M, Neff CP, Joosten LAB, Marchetti C and Dinarello CA: Activation of host-NLRP3 inflammasome in myeloid cells dictates response to anti-PD-1 therapy in metastatic breast cancers. Pharmaceuticals (Basel). 15:5742022. View Article : Google Scholar : PubMed/NCBI | |
|
Jing L, An Y, Cai T, Xiang J, Li B, Guo J, Ma X, Wei L, Tian Y, Cheng X, et al: A subpopulation of CD146+ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome. Cell Mol Immunol. 20:908–923. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Yan L, Liu Y, Ma XF, Hou D, Zhang YH, Sun Y, Shi SS, Forouzanfar T, Lin HY, Fan J and Wu G: Triclabendazole induces pyroptosis by activating caspase-3 to cleave GSDME in breast cancer cells. Front Pharmacol. 12:6700812021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Zhang H, Li D, Zhou X, Qin Q and Zhang Q: Caspase-3-mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway. J Cell Mol Med. 25:8159–8168. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yang X, Cui X, Wang G, Zhou M, Wu Y, Du Y, Li X and Xu T: HDAC inhibitor regulates the tumor immune microenvironment via pyroptosis in triple negative breast cancer. Mol Carcinog. 63:1800–1813. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Adams NM, Grassmann S and Sun JC: Clonal expansion of innate and adaptive lymphocytes. Nat Rev Immunol. 20:694–707. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Boraschi D, Toepfer E and Italiani P: Innate and germline immune memory: Specificity and heritability of the ancient immune mechanisms for adaptation and survival. Front Immunol. 15:13865782024. View Article : Google Scholar : PubMed/NCBI | |
|
Sette A and Crotty S: Adaptive immunity to SARS-CoV-2 and COVID-19. Cell. 184:861–880. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Fridman WH, Pagès F, Sautès-Fridman C and Galon J: The immune contexture in human tumours: Impact on clinical outcome. Nat Rev Cancer. 12:298–306. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Loi S, Drubay D, Adams S, Pruneri G, Francis PA, Lacroix-Triki M, Joensuu H, Dieci MV, Badve S, Demaria S, et al: Tumor-infiltrating lymphocytes and prognosis: A pooled individual patient analysis of early-stage triple-negative breast cancers. J Clin Oncol. 37:559–569. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Herbert JA and Panagiotou S: Immune response to viruses. Encycl Infect Immun. 1:429–444. 2022. | |
|
Schumacher TN and Schreiber RD: Neoantigens in cancer immunotherapy. Science. 348:69–74. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Borst J, Ahrends T, Bąbała N, Melief CJM and Kastenmüller W: CD4+ T cell help in cancer immunology and immunotherapy. Nat Rev Immunol. 18:635–647. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Qian D, Li J, Huang M, Cui Q, Liu X and Sun K: Dendritic cell vaccines in breast cancer: Immune modulation and immunotherapy. Biomed Pharmacother. 162:1146852023. View Article : Google Scholar : PubMed/NCBI | |
|
Cai L and Li Y, Tan J, Xu L and Li Y: Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy. J Hematol Oncol. 16:1012023. View Article : Google Scholar : PubMed/NCBI | |
|
Jin M, Fang J, Peng J, Wang X, Xing P, Jia K, Hu J, Wang D, Ding Y, Wang X, et al: PD-1/PD-L1 immune checkpoint blockade in breast cancer: Research insights and sensitization strategies. Mol Cancer. 23:2662024. View Article : Google Scholar : PubMed/NCBI | |
|
Schumacher TN and Thommen DS: Tertiary lymphoid structures in cancer. Science. 375:eabf94192022. View Article : Google Scholar : PubMed/NCBI | |
|
Saxena M, van der Burg SH, Melief CJM and Bhardwaj N: Therapeutic cancer vaccines. Nat Rev Cancer. 21:360–378. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Chamorro DF, Somes LK and Hoyos V: Engineered adoptive T-cell therapies for breast cancer: Current progress, challenges, and potential. Cancers (Basel). 16:1242023. View Article : Google Scholar : PubMed/NCBI | |
|
Cejuela M, Vethencourt A and Pernas S: Immune checkpoint inhibitors and novel immunotherapy approaches for breast cancer. Curr Oncol Rep. 24:1801–1819. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Duong E, Fessenden TB, Lutz E, Dinter T, Yim L, Blatt S, Bhutkar A, Wittrup KD and Spranger S: Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity. Immunity. 55:308–323.e9. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu X, Huang Q, Chen X and Zhang B, Liang J and Zhang B: B cells and tertiary lymphoid structures in tumors: immunity cycle, clinical impact, and therapeutic applications. Theranostics. 15:605–631. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Thol K, Pawlik P and McGranahan N: Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution. Genome Med. 14:1372022. View Article : Google Scholar : PubMed/NCBI | |
|
Mirlekar B: Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy. SAGE Open Med. 10:205031212110690122022. View Article : Google Scholar : PubMed/NCBI | |
|
Li C, Jiang P, Wei S, Xu X and Wang J: Regulatory T cells in tumor microenvironment: New mechanisms, potential therapeutic strategies and future prospects. Mol Cancer. 19:1162020. View Article : Google Scholar : PubMed/NCBI | |
|
Ravichandran KS: Find-me and eat-me signals in apoptotic cell clearance: Progress and conundrums. J Exp Med. 207:1807–1817. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Bertheloot D, Latz E and Franklin BS: Necroptosis, pyroptosis and apoptosis: An intricate game of cell death. Cell Mol Immunol. 18:1106–1121. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Tanzer MC, Frauenstein A, Stafford CA, Phulphagar K, Mann M and Meissner F: Quantitative and dynamic catalogs of proteins released during apoptotic and necroptotic cell death. Cell Rep. 30:1260–1270.e5. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Nössing C and Ryan KM: 50 Years on and still very much alive: ‘Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics’. Br J Cancer. 128:426–431. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang R, Lan C, Benlagha K, Camara NOS, Miller H, Kubo M, Heegaard S, Lee P, Yang L, Forsman H, et al: The interaction of innate immune and adaptive immune system. MedComm (2020). 5:e7142024. View Article : Google Scholar : PubMed/NCBI | |
|
Moyer A, Tanaka K and Cheng EH: Apoptosis in cancer biology and therapy. Annu Rev Pathol. 20:303–328. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Nagata S and Tanaka M: Programmed cell death and the immune system. Nat Rev Immunol. 17:333–340. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Halkom A, Wu H and Lu Q: Contribution of mouse models in our understanding of lupus. Int Rev Immunol. 39:174–187. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Rieux-Laucat F, Magérus-Chatinet A and Neven B: The autoimmune lymphoproliferative syndrome with defective FAS or FAS-ligand functions. J Clin Immunol. 38:558–568. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Leis K, Gałązka P, Kazik J, Jamrożek T, Bereźnicka W and Czajkowski R: Resveratrol in the treatment of asthma based on an animal model. Postepy Dermatol Alergol. 39:433–438. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Juric V, Hudson L, Fay J, Richards CE, Jahns H, Verreault M, Bielle F, Idbaih A, Lamfers MLM, Hopkins AM, et al: Transcriptional CDK inhibitors, CYC065 and THZ1 promote Bim-dependent apoptosis in primary and recurrent GBM through cell cycle arrest and Mcl-1 downregulation. Cell Death Dis. 12:7632021. View Article : Google Scholar : PubMed/NCBI | |
|
Kotzin JJ, Spencer SP, McCright SJ, Kumar DBU, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, et al: The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature. 537:239–243. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Guo H, Yang Y, Lou Y, Zuo Z, Cui H, Deng H, Zhu Y and Fang J: Apoptosis and DNA damage mediated by ROS involved in male reproductive toxicity in mice induced by Nickel. Ecotoxicol Environ Saf. 268:1156792023. View Article : Google Scholar : PubMed/NCBI | |
|
Green DR: The mitochondrial pathway of apoptosis part II: The BCL-2 protein family. Cold Spring Harb Perspect Biol. 14:a0410462022. View Article : Google Scholar : PubMed/NCBI | |
|
Yadav N, Gogada R, O'Malley J, Gundampati RK, Jayanthi S, Hashmi S, Lella R, Zhang D, Wang J, Kumar R, et al: Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer. Biochim Biophys Acta Mol Cell Res. 1867:1185732020. View Article : Google Scholar : PubMed/NCBI | |
|
Sahoo G, Samal D, Khandayataray P and Murthy MK: A review on caspases: Key regulators of biological activities and apoptosis. Mol Neurobiol. 60:5805–5837. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Shoshan-Barmatz V, Arif T and Shteinfer-Kuzmine A: Apoptotic proteins with non-apoptotic activity: Expression and function in cancer. Apoptosis. 28:730–753. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Li Y, Wu Y, Wu A, Xiao B, Liu X, Zhang Q, Feng Y, Yuan Z, Yi J, et al: Endoplasmic reticulum stress promotes oxidative stress, inflammation, and apoptosis: A novel mechanism of citrinin-induced renal injury and dysfunction. Ecotoxicol Environ Saf. 284:1169462024. View Article : Google Scholar : PubMed/NCBI | |
|
Fu X, Cui J, Meng X, Jiang P, Zheng Q, Zhao W and Chen X: Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors (Review). Oncol Rep. 45:801–808. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Kara M and Oztas E: Endoplasmic reticulum stress-mediated cell death. Program Cell Death. 1:1–14. 2020. | |
|
Wen N, Lv Q and Du ZG: MicroRNAs involved in drug resistance of breast cancer by regulating autophagy. J Zhejiang Univ Sci B. 21:690–702. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liang DH, Choi DS, Ensor JE, Kaipparettu BA, Bass BL and Chang JC: The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair. Cancer Lett. 376:249–258. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Cook KL, Shajahan AN, Wärri A, Jin L, Hilakivi-Clarke LA and Clarke R: Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Res. 72:3337–3349. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Crawford AC, Riggins RB, Shajahan AN, Zwart A and Clarke R: Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis. PLoS One. 5:e86042010. View Article : Google Scholar : PubMed/NCBI | |
|
Thomas M, Davis T, Loos B, Sishi B, Huisamen B, Strijdom H and Engelbrecht AM: Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells. Cell Biochem Funct. 36:65–79. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Martin S, Dudek-Peric AM, Garg AD, Roose H, Demirsoy S, Van Eygen S, Mertens F, Vangheluwe P, Vankelecom H and Agostinis P: An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAFV600E inhibitor-resistant metastatic melanoma cells. Autophagy. 13:1512–1527. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Bednarczyk M, Zmarzły N, Grabarek B, Mazurek U and Muc-Wierzgoń M: Genes involved in the regulation of different types of autophagy and their participation in cancer pathogenesis. Oncotarget. 9:34413–34428. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Daskalaki I, Gkikas I and Tavernarakis N: Hypoxia and selective autophagy in cancer development and therapy. Front Cell Dev Biol. 6:1042018. View Article : Google Scholar : PubMed/NCBI | |
|
Bousquet G, El Bouchtaoui M, Sophie T, Leboeuf C, de Bazelaire C, Ratajczak P, Giacchetti S, de Roquancourt A, Bertheau P, Verneuil L, et al: Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer. Oncotarget. 8:35205–35221. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yeo SK, Wen J, Chen S and Guan JL: Autophagy differentially regulates distinct breast cancer stem-like cells in murine models via EGFR/Stat3 and Tgfβ/Smad signaling. Cancer Res. 76:3397–3410. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Vera-Ramirez L, Vodnala SK, Nini R, Hunter KW and Green JE: Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence. Nat Commun. 9:19442018. View Article : Google Scholar : PubMed/NCBI | |
|
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE and Shaw RJ: AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 30:214–226. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell TG, Bisetto S, Velasco-Velázquez MA, Jiao X, Li Z, et al: Cyclin D1 restrains oncogene-induced autophagy by regulating the AMPK-LKB1 signaling axis. Cancer Res. 77:3391–3405. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Shi J, Gao W and Shao F: Pyroptosis: Gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 42:245–254. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Galluzzi L, Buqué A, Kepp O, Zitvogel L and Kroemer G: Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 17:97–111. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, et al: Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 526:666–671. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Gao W, Shi X, Ding J, Liu W, He H, Wang K and Shao F: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 547:99–103. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, et al: Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. 579:415–420. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Q, Wang Y, Ding J, Wang C, Zhou X, Gao W, Huang H, Shao F and Liu Z: A bioorthogonal system reveals antitumour immune function of pyroptosis. Nature. 579:421–426. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Peng J, Mi X and Yang M: p53-GSDME elevation: A path for CDK7 inhibition to suppress breast cancer cell survival. Front Mol Biosci. 8:6974572021. View Article : Google Scholar : PubMed/NCBI | |
|
Broderick NA: A common origin for immunity and digestion. Front Immunol. 6:722015. View Article : Google Scholar : PubMed/NCBI | |
|
Uribe-Querol E and Rosales C: Phagocytosis: Our current understanding of a universal biological process. Front Immunol. 11:10662020. View Article : Google Scholar : PubMed/NCBI | |
|
Kourtzelis I, Hajishengallis G and Chavakis T: Phagocytosis of apoptotic cells in resolution of inflammation. Front Immunol. 11:5532020. View Article : Google Scholar : PubMed/NCBI | |
|
Sprooten J, Vanmeerbeek I, Datsi A, Govaerts J, Naulaerts S, Laureano RS, Borràs DM, Calvet A, Malviya V, Kuballa M, et al: Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells. Cell Rep Med. 5:1013772024. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HJ, Park JH, Kim HC, Kim CW, Kang I and Lee HK: Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma. Nat Commun. 13:62112022. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Z, Davidson D, Li R, Zhong MC, Qian J, Chen J and Veillette A: Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity. Cell Rep. 37:1101112021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen D, Varanasi SK, Hara T, Traina K, Sun M, McDonald B, Farsakoglu Y, Clanton J, Xu S, Garcia-Rivera L, et al: CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma. Immunity. 56:2086–2104.e8. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Wang Y, Yang Y, Weng L, Wu Q, Zhang J, Zhao P, Fang L, Shi Y and Wang P: Emerging phagocytosis checkpoints in cancer immunotherapy. Signal Transduct Target Ther. 8:1042023. View Article : Google Scholar : PubMed/NCBI | |
|
Mantovani A, Allavena P, Marchesi F and Garlanda C: Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 21:799–820. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Gabriele M and Pucci L: Diet bioactive compounds: implications for oxidative stress and inflammation in the vascular system. Endocr Metab Immune Disord Drug Targets. 17:264–275. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Stumpf F, Keller B, Gressies C and Schuetz P: Inflammation and nutrition: Friend or foe? Nutrients. 15:11592023. View Article : Google Scholar : PubMed/NCBI | |
|
Ye J, Hu Y, Chen X, Chang C and Li K: Comparative effects of different nutritional supplements on inflammation, nutritional status, and clinical outcomes in colorectal cancer patients: A systematic review and network meta-analysis. Nutrients. 15:27722023. View Article : Google Scholar : PubMed/NCBI | |
|
Soeters PB, Wolfe RR and Shenkin A: Hypoalbuminemia: Pathogenesis and clinical significance. JPEN J Parenter Enteral Nutr. 43:181–193. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wiedermann CJ: Hypoalbuminemia as surrogate and culprit of infections. Int J Mol Sci. 22:44962021. View Article : Google Scholar : PubMed/NCBI | |
|
Pan C, Gu Y and Ni Q: The prognostic value of serum albumin to globulin ratio in patients with breast cancer: A retrospective study. Breast Cancer (Dove Med Press). 16:403–411. 2024.PubMed/NCBI | |
|
Wei C, Ai H, Mo D, Wang P, Wei L, Liu Z, Li P, Huang T and Liu M: A nomogram based on inflammation and nutritional biomarkers for predicting the survival of breast cancer patients. Front Endocrinol (Lausanne). 15:13888612024. View Article : Google Scholar : PubMed/NCBI | |
|
Xiang M, Zhang H, Tian J, Yuan Y, Xu Z and Chen J: Low serum albumin levels and high neutrophil counts are predictive of a poorer prognosis in patients with metastatic breast cancer. Oncol Lett. 24:4322022. View Article : Google Scholar : PubMed/NCBI | |
|
Al-Shaer AE, Buddenbaum N and Shaikh SR: Polyunsaturated fatty acids, specialized pro-resolving mediators, and targeting inflammation resolution in the age of precision nutrition. Biochim Biophys Acta Mol Cell Biol Lipids. 1866:1589362021. View Article : Google Scholar : PubMed/NCBI | |
|
Wautier JL and Wautier MP: Pro- and anti-inflammatory prostaglandins and cytokines in humans: A mini review. Int J Mol Sci. 24:96472023. View Article : Google Scholar : PubMed/NCBI | |
|
Iddir M, Brito A, Dingeo G, Fernandez Del Campo SS, Samouda H, La Frano MR and Bohn T: Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during the COVID-19 crisis. Nutrients. 12:15622020. View Article : Google Scholar : PubMed/NCBI | |
|
Flores J, White BM, Brea RJ, Baskin JM and Devaraj NK: Lipids: Chemical tools for their synthesis, modification, and analysis. Chem Soc Rev. 49:4602–4614. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Choi RH, Tatum SM, Symons JD, Summers SA and Holland WL: Ceramides and other sphingolipids as drivers of cardiovascular disease. Nat Rev Cardiol. 18:701–711. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yu B, Yu L and Klionsky DJ: Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19. Med Hypotheses. 155:1106682021. View Article : Google Scholar : PubMed/NCBI | |
|
Yoon H, Shaw JL, Haigis MC and Greka A: Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity. Mol Cell. 81:3708–3730. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Ruan XZ, Varghese Z and Moorhead JF: An update on the lipid nephrotoxicity hypothesis. Nat Rev Nephrol. 5:713–721. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Mitrofanova A, Merscher S and Fornoni A: Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease. Nat Rev Nephrol. 19:629–645. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
D'Agati VD, Chagnac A, de Vries AP, Levi M, Porrini E, Herman-Edelstein M and Praga M: Obesity-related glomerulopathy: Clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol. 12:453–471. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D and Kahn BB: PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. J Clin Invest. 129:4138–4150. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Bhat N and Mani A: Dysregulation of lipid and glucose metabolism in nonalcoholic fatty liver disease. Nutrients. 15:23232023. View Article : Google Scholar : PubMed/NCBI | |
|
Løvsletten NG, Bakke SS, Kase ET, Ouwens DM, Thoresen GH and Rustan AC: Increased triacylglycerol-fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid. PLoS One. 13:e02080482018. View Article : Google Scholar : PubMed/NCBI | |
|
Jelenik T, Flögel U, Álvarez-Hernández E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, et al: Insulin resistance and vulnerability to cardiac ischemia. Diabetes. 67:2695–2702. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ioannou MS, Jackson J, Sheu SH, Chang CL, Weigel AV, Liu H, Pasolli HA, Xu CS, Pang S, Matthies D, et al: Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity. Cell. 177:1522–1535.e14. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Qian Y, Fang Q, Zhong P, Li W, Wang L, Fu W, Zhang Y, Xu Z, Li X and Liang G: Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2. Nat Commun. 8:139972017. View Article : Google Scholar : PubMed/NCBI | |
|
Nicholas DA, Zhang K, Hung C, Glasgow S, Aruni AW, Unternaehrer J, Payne KJ, Langridge WHR and De Leon M: Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β. PLoS One. 12:e01767932017. View Article : Google Scholar : PubMed/NCBI | |
|
Tabas I: Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: The importance of lesion stage and phagocytic efficiency. Arterioscler Thromb Vasc Biol. 25:2255–2264. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Neri CR, Scapaticci S, Chiarelli F and Giannini C: Liver steatosis: A marker of metabolic risk in children. Int J Mol Sci. 23:48222022. View Article : Google Scholar : PubMed/NCBI | |
|
Jarczak D and Nierhaus A: Cytokine storm-definition, causes, and implications. Int J Mol Sci. 23:117402022. View Article : Google Scholar : PubMed/NCBI | |
|
Dinarello CA: Proinflammatory cytokines. Chest. 118:503–508. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Nie J, Zhou L, Tian W, Liu X, Yang L, Yang X, Zhang Y, Wei S, Wang DW and Wei J: Deep insight into cytokine storm: From pathogenesis to treatment. Signal Transduct Target Ther. 10:1122025. View Article : Google Scholar : PubMed/NCBI | |
|
Man SM, Karki R and Kanneganti TD: Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev. 277:61–75. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Afzal S, Fiaz K, Noor A, Sindhu AS, Hanif A, Bibi A, Asad M, Nawaz S, Zafar S, Ayub S, et al: Interrelated oncogenic viruses and breast cancer. Front Mol Biosci. 9:7811112022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Q, Nie DY, Ba-Alawi W, Ji Y, Zhang Z, Cruickshank J, Haight J, Ciamponi FE, Chen J, Duan S, et al: PRMT inhibition induces a viral mimicry response in triple-negative breast cancer. Nat Chem Biol. 18:821–830. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zu Y, Ou Z, Wu D, Liu W, Liu L, Wu D, Zhao Y, Ren P, Zhang Y, Li W, et al: Genetic characteristics of human papillomavirus type 16, 18, 52 and 58 in southern China. Genomics. 113:3895–3906. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Khalil MI, Yang C, Vu L, Chadha S, Nabors H, Welbon C, James CD, Morgan IM, Spanos WC and Pyeon D: HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer. PLoS Pathog. 19:e10111712023. View Article : Google Scholar : PubMed/NCBI | |
|
Antonioli M, Pagni B, Vescovo T, Ellis R, Cosway B, Rollo F, Bordoni V, Agrati C, Labus M, Covello R, et al: HPV sensitizes OPSCC cells to cisplatin-induced apoptosis by inhibiting autophagy through E7-mediated degradation of AMBRA1. Autophagy. 17:2842–2855. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wyżewski Z, Mielcarska MB, Gregorczyk-Zboroch KP and Myszka A: Virus-mediated inhibition of apoptosis in the context of EBV-associated diseases: Molecular mechanisms and therapeutic perspectives. Int J Mol Sci. 23:72652022. View Article : Google Scholar : PubMed/NCBI | |
|
Yu Z, Wang Y, Liu L, Zhang X, Jiang S and Wang B: Apoptosis disorder, a key pathogenesis of HCMV-related diseases. Int J Mol Sci. 22:41062021. View Article : Google Scholar : PubMed/NCBI | |
|
Gatti-Mays ME, Balko JM, Gameiro SR, Bear HD, Prabhakaran S, Fukui J, Disis ML, Nanda R, Gulley JL, Kalinsky K, et al: If we build it they will come: Targeting the immune response to breast cancer. NPJ Breast Cancer. 5:372019. View Article : Google Scholar : PubMed/NCBI | |
|
Huang G, Zhou J, Chen J and Liu G: Identification of pyroptosis related subtypes and tumor microenvironment infiltration characteristics in breast cancer. Sci Rep. 12:106402022. View Article : Google Scholar : PubMed/NCBI | |
|
Berkel C and Cacan E: Differential expression and copy number variation of gasdermin (GSDM) family members, pore-forming proteins in pyroptosis, in normal and malignant serous ovarian tissue. Inflammation. 44:2203–2216. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu C, Xu S, Jiang R, Yu Y, Bian J and Zou Z: The gasdermin family: Emerging therapeutic targets in diseases. Signal Transduct Target Ther. 9:872024. View Article : Google Scholar : PubMed/NCBI | |
|
Wu H, Qian D, Bai X and Sun S: Targeted pyroptosis is a potential therapeutic strategy for cancer. J Oncol. 2022:25155252022. View Article : Google Scholar : PubMed/NCBI | |
|
Hu H, Yang H, Liu Y and Yan B: Pathogenesis of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis: A concise review with an emphasis on Type I interferon system. Front Med (Lausanne). 8:8331142022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu L, Lu H, Pan Y, Liu C, Wang J, Chen B and Wang Y: The role of pyroptosis and its crosstalk with immune therapy in breast cancer. Front Immunol. 13:9739352022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Q, Huang L, Qin G, Qiao Y, Ren F, Shen C, Wang S, Liu S, Lian J, Wang D, et al: Cancer-associated fibroblasts induce monocytic myeloid-derived suppressor cell generation via IL-6/exosomal miR-21-activated STAT3 signaling to promote cisplatin resistance in esophageal squamous cell carcinoma. Cancer Lett. 518:35–48. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zaarour RF, Ribeiro M, Azzarone B, Kapoor S and Chouaib S: Tumor microenvironment-induced tumor cell plasticity: Relationship with hypoxic stress and impact on tumor resistance. Front Oncol. 13:12225752023. View Article : Google Scholar : PubMed/NCBI | |
|
Igney FH and Krammer PH: Death and anti-death: Tumour resistance to apoptosis. Nat Rev Cancer. 2:277–288. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Liao M, Qin R, Huang W, Zhu HP, Peng F, Han B and Liu B: Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: A revisited perspective from molecular mechanisms to targeted therapies. J Hematol Oncol. 15:442022. View Article : Google Scholar : PubMed/NCBI | |
|
Attiq A and Afzal S: Trinity of inflammation, innate immune cells and cross-talk of signalling pathways in tumour microenvironment. Front Pharmacol. 14:12557272023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang JL, Hua SN, Bao HJ, Yuan J, Zhao Y and Chen S: Pyroptosis and inflammasomes in cancer and inflammation. MedComm (2020). 4:e3742023. View Article : Google Scholar : PubMed/NCBI | |
|
Ji X, Huang X, Li C, Guan N, Pan T, Dong J and Li L: Effect of tumor-associated macrophages on the pyroptosis of breast cancer tumor cells. Cell Commun Signal. 21:1972023. View Article : Google Scholar : PubMed/NCBI | |
|
van Beek JJP, Martens AWJ, Bakdash G and de Vries IJM: Innate lymphoid cells in tumor immunity. Biomedicines. 4:72016. View Article : Google Scholar : PubMed/NCBI | |
|
Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, et al: Innate lymphoid cells-a proposal for uniform nomenclature. Nat Rev Immunol. 13:145–149. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Verma D, Verma M and Mishra R: Stem cell therapy and innate lymphoid cells. Stem Cells Int. 2022:35305202022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao M, Shao F, Yu D, Zhang J, Liu Z, Ma J, Xia P and Wang S: Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis. Nat Commun. 13:76002022. View Article : Google Scholar : PubMed/NCBI | |
|
Srivastava RK, Sapra L, Bhardwaj A, Mishra PK, Verma B and Baig Z: Unravelling the immunobiology of innate lymphoid cells (ILCs): Implications in health and disease. Cytokine Growth Factor Rev. 74:56–75. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Danziger N, Sokol ES, Graf RP, Hiemenz MC, Maule J, Parimi V, Palmieri C, Pusztai L, Ross JS and Huang RSP: Variable landscape of PD-L1 expression in breast carcinoma as detected by the DAKO 22C3 immunohistochemistry assay. Oncologist. 28:319–326. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Levi I, Amsalem H, Nissan A, Darash-Yahana M, Peretz T, Mandelboim O and Rachmilewitz J: Characterization of tumor infiltrating natural killer cell subset. Oncotarget. 6:13835–13843. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Montaldo E, Vacca P, Chiossone L, Croxatto D, Loiacono F, Martini S, Ferrero S, Walzer T, Moretta L and Mingari MC: Unique eomes(+) NK cell subsets are present in uterus and decidua during early pregnancy. Front Immunol. 6:6462016. View Article : Google Scholar : PubMed/NCBI | |
|
Salimi M, Wang R, Yao X, Li X, Wang X, Hu Y, Chang X, Fan P, Dong T and Ogg G: Activated innate lymphoid cell populations accumulate in human tumour tissues. BMC Cancer. 18:3412018. View Article : Google Scholar : PubMed/NCBI | |
|
Sivori S, Pende D, Quatrini L, Pietra G, Della Chiesa M, Vacca P, Tumino N, Moretta F, Mingari MC, Locatelli F and Moretta L: NK cells and ILCs in tumor immunotherapy. Mol Aspects Med. 80:1008702021. View Article : Google Scholar : PubMed/NCBI | |
|
Fenis A, Demaria O, Gauthier L, Vivier E and Narni-Mancinelli E: New immune cell engagers for cancer immunotherapy. Nat Rev Immunol. 24:471–486. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Liu H, Wang Z, Zhou Y and Yang Y: MDSCs in breast cancer: An important enabler of tumor progression and an emerging therapeutic target. Front Immunol. 14:11992732023. View Article : Google Scholar : PubMed/NCBI | |
|
Nakasone ES, Hurvitz SA and McCann KE: Harnessing the immune system in the battle against breast cancer. Drugs Context. 7:2125202018. View Article : Google Scholar : PubMed/NCBI | |
|
Revel M, Daugan MV, Sautés-Fridman C, Fridman WH and Roumenina LT: Complement system: Promoter or suppressor of cancer progression? Antibodies (Basel). 9:572020. View Article : Google Scholar : PubMed/NCBI | |
|
Deslouches B and Di YP: Antimicrobial peptides with selective antitumor mechanisms: Prospect for anticancer applications. Oncotarget. 8:46635–46651. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Angelico G, Broggi G, Tinnirello G, Puzzo L, Vecchio GM, Salvatorelli L, Memeo L, Santoro A, Farina J, Mulé A, et al: Tumor infiltrating lymphocytes (TILS) and PD-L1 expression in breast cancer: A review of current evidence and prognostic implications from Pathologist's perspective. Cancers (Basel). 15:44792023. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Y, Jiang Q, Ou Y, Zhang F, Qing K, Sun Y, Lu W, Zhu H, Gong F, Lei P and Shen G: BIP induces mice CD19(hi) regulatory B cells producing IL-10 and highly expressing PD-L1, FasL. Mol Immunol. 69:44–51. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Burugu S, Asleh-Aburaya K and Nielsen TO: Immune infiltrates in the breast cancer microenvironment: Detection, characterization and clinical implication. Breast Cancer. 24:3–15. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Shang Q, Yu X, Sun Q, Li H, Sun C and Liu L: Polysaccharides regulate Th1/Th2 balance: A new strategy for tumor immunotherapy. Biomed Pharmacother. 170:1159762024. View Article : Google Scholar : PubMed/NCBI | |
|
Togashi Y, Shitara K and Nishikawa H: Regulatory T cells in cancer immunosuppression-implications for anticancer therapy. Nat Rev Clin Oncol. 16:356–371. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Dolina JS, Van Braeckel-Budimir N, Thomas GD and Salek-Ardakani S: CD8+ T cell exhaustion in cancer. Front Immunol. 12:7152342021. View Article : Google Scholar : PubMed/NCBI | |
|
Sauer N, Matkowski I, Bodalska G, Murawski M, Dzięgiel P and Calik J: Prognostic role of prolactin-induced protein (PIP) in breast cancer. Cells. 12:22522023. View Article : Google Scholar : PubMed/NCBI | |
|
Lehmann BD, Colaprico A, Silva TC, Chen J, An H, Ban Y, Huang H, Wang L, James JL, Balko JM, et al: Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes. Nat Commun. 12:62762021. View Article : Google Scholar : PubMed/NCBI | |
|
Truax AD, Thakkar M and Greer SF: Dysregulated recruitment of the histone methyltransferase EZH2 to the class II transactivator (CIITA) promoter IV in breast cancer cells. PLoS One. 7:e360132012. View Article : Google Scholar : PubMed/NCBI | |
|
Kubaev A, Faez Sead F, Pirouzbakht M, Nazari M, Riyahi H, Sargazi Aval O, Hasanvand A, Mousavi F and Soleimani Samarkhazan H: Platelet-derived extracellular vesicles: Emerging players in hemostasis and thrombosis. J Liposome Res. 35:334–344. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Han X, Song X, Xiao Z, Zhu G, Gao R, Ni B and Li J: Study on the mechanism of MDSC-platelets and their role in the breast cancer microenvironment. Front Cell Dev Biol. 12:13104422024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Zhang K, Feng J, Wang D and Liu J: The progress of platelets in breast cancer. Cancer Manag Res. 15:811–821. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Mendoza-Almanza G, Burciaga-Hernández L, Maldonado V, Melendez-Zajgla J and Olmos J: Role of platelets and breast cancer stem cells in metastasis. World J Stem Cells. 12:1237–1254. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Catani MV, Savini I, Tullio V and Gasperi V: The ‘Janus Face’ of platelets in cancer. Int J Mol Sci. 21:7882020. View Article : Google Scholar : PubMed/NCBI | |
|
Zielińska KA and Katanaev VL: The signaling duo CXCL12 and CXCR4: Chemokine fuel for breast cancer tumorigenesis. Cancers (Basel). 12:30712020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X, Zhao S, Wang Z and Gao T: Platelets involved tumor cell EMT during circulation: Communications and interventions. Cell Commun Signal. 20:822022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, He Y, Hu F, Hu C, Sun Y, Yang K and Yang S: Metabolic reprogramming of immune cells in the tumor microenvironment. International Int J Mol Sci. 25:122232024. View Article : Google Scholar | |
|
Singh L, Nair L, Kumar D, Arora MK, Bajaj S, Gadewar M, Mishra SS, Rath SK, Dubey AK, Kaithwas G, et al: Hypoxia induced lactate acidosis modulates tumor microenvironment and lipid reprogramming to sustain the cancer cell survival. Front Oncol. 13:10342052023. View Article : Google Scholar : PubMed/NCBI | |
|
Yan Y, Huang L, Liu Y, Yi M, Chu Q, Jiao D and Wu K: Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: Implications for antitumor immunity. J Hematol Oncol. 15:1042022. View Article : Google Scholar : PubMed/NCBI | |
|
Guo R, Wang R, Zhang W, Li Y, Wang Y, Wang H, Li X and Song J: Macrophage polarisation in the tumour microenvironment: recent research advances and therapeutic potential of different macrophage reprogramming. Cancer Control. 32:107327482513166042025. View Article : Google Scholar : PubMed/NCBI | |
|
Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, et al: LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells. Cell Metab. 24:657–671. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, et al: Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell. 162:1229–1241. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Xie J, Guo Z, Zhu Y, Ma M and Jia G: Peripheral blood inflammatory indexes in breast cancer: A review. Medicine (Baltimore). 102:e363152023. View Article : Google Scholar : PubMed/NCBI | |
|
Shibabaw T, Teferi B and Ayelign B: The role of Th-17 cells and IL-17 in the metastatic spread of breast cancer: As a means of prognosis and therapeutic target. Front Immunol. 14:10948232023. View Article : Google Scholar : PubMed/NCBI | |
|
Danforth DN: The Role of chronic inflammation in the development of breast cancer. (Basel). 13:39182021. View Article : Google Scholar | |
|
Ruan GT, Xie HL, Hu CL, Liu CA, Zhang HY, Zhang Q, Wang ZW, Zhang X, Ge YZ, Lin SQ, et al: Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: A prospective multicenter cohort. Sci Rep. 13:43032023. View Article : Google Scholar : PubMed/NCBI | |
|
Egelston CA, Avalos C, Tu TY, Simons DL, Jimenez G, Jung JY, Melstrom L, Margolin K, Yim JH, Kruper L, et al: Human breast tumor-infiltrating CD8+ T cells retain polyfunctionality despite PD-1 expression. Nat Commun. 9:42972018. View Article : Google Scholar : PubMed/NCBI | |
|
Hartman ZC, Poage GM, den Hollander P, Tsimelzon A, Hill J, Panupinthu N, Zhang Y, Mazumdar A, Hilsenbeck SG, Mills GB and Brown PH: Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. Cancer Res. 73:3470–3480. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Jin K, Pandey NB and Popel AS: Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis. Breast Cancer Res. 20:542018. View Article : Google Scholar : PubMed/NCBI | |
|
Korkaya H, Kim GI, Davis A, Malik F, Henry NL, Ithimakin S, Quraishi AA, Tawakkol N, D'Angelo R, Paulson AK, et al: Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population. Mol Cell. 47:570–584. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yu H, Lin L, Zhang Z, Zhang H and Hu H: Targeting NF-κB pathway for the therapy of diseases: Mechanism and clinical study. Signal Transduct Target Ther. 5:2092020. View Article : Google Scholar : PubMed/NCBI | |
|
Li Z, Liu M, Li J, Yan G and Xu X: Diosmetin alleviates AFB1-induced endoplasmic reticulum stress, autophagy, and apoptosis via PI3K/AKT pathway in mice. Ecotoxicol Environ Saf. 292:1179972025. View Article : Google Scholar : PubMed/NCBI | |
|
Diep S, Maddukuri M, Yamauchi S, Geshow G and Delk NA: Interleukin-1 and nuclear factor kappa B signaling promote breast cancer progression and treatment resistance. Cells. 11:16732022. View Article : Google Scholar : PubMed/NCBI | |
|
Xu J, Zhang J, Mao QF, Wu J and Wang Y: The interaction between autophagy and JAK/STAT3 signaling pathway in tumors. Front Genet. 13:8803592022. View Article : Google Scholar : PubMed/NCBI | |
|
Johnson DE, O'Keefe RA and Grandis JR: Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 15:234–248. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Dai Z, Liu WC, Chen XY, Wang X, Li JL and Zhang X: Gasdermin D-mediated pyroptosis: Mechanisms, diseases, and inhibitors. Front Immunol. 14:11786622023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Xu X, Ye P, Jiang Z, Tian L, Yin Y and Feng L: Genetic evidence for causal effects of inflammatory protein factors on breast cancer. Discov Oncol. 16:14902025. View Article : Google Scholar : PubMed/NCBI | |
|
Liu F, Li L, Lan M, Zou T, Kong Z, Cai T, Wu XY and Cai Y: Key factor regulating inflammatory microenvironment, metastasis, and resistance in breast cancer: Interleukin-1 signaling. Mediators Inflamm. 2021:77858902021. View Article : Google Scholar : PubMed/NCBI | |
|
Dong W, Gu X, Li J and Zhuang Z: Characterization of immune landscape and prognostic value of IL-17-related signature in invasive breast cancer. Transl Cancer Res. 14:907–929. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Cui Y, Cui S, Lu W, Wang Y, Zhuo Z, Wang R, Zhang D, Wu X, Chang L, Zuo X, et al: CRP, IL-1α, IL-1β, and IL-6 levels and the risk of breast cancer: A two-sample Mendelian randomization study. Sci Rep. 14:19822024. View Article : Google Scholar : PubMed/NCBI | |
|
Kehm RD, McDonald JA, Fenton SE, Kavanaugh-Lynch M, Leung KA, McKenzie KE, Mandelblatt JS and Terry MB: Inflammatory biomarkers and breast cancer risk: A systematic review of the evidence and future potential for intervention research. Int J Environ Res Public Health. 17:54452020. View Article : Google Scholar : PubMed/NCBI | |
|
Liang Y, He J, Chen X, Yin L, Yuan Q, Zeng Q, Zu X and Shen Y: The emerging roles of metabolism in the crosstalk between breast cancer cells and tumor-associated macrophages. Int J Biol Sci. 19:4915–4930. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Geng X, Hou J and Wu G: New insights into M1/M2 macrophages: Key modulators in cancer progression. Cancer Cell Int. 21:3892021. View Article : Google Scholar : PubMed/NCBI | |
|
Strizova Z, Benesova I, Bartolini R, Novysedlak R, Cecrdlova E, Foley LK and Striz I: M1/M2 macrophages and their overlaps-myth or reality? Clin Sci (Lond). 137:1067–1093. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang C, Lin Y, Zhu H, Zhou Y, Mao F, Huang X, Sun Q and Li C: The prognostic and clinical value of tumor-associated macrophages in patients with breast cancer: A systematic review and meta-analysis. Front Oncol. 12:9058462022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu C, Dong S, Huang R and Chen X: Cancer-associated adipocytes and breast cancer: Intertwining in the tumor microenvironment and challenges for cancer therapy. Cancers (Basel). 15:7262023. View Article : Google Scholar : PubMed/NCBI | |
|
Maliniak ML, Miller-Kleinhenz J, Cronin-Fenton DP, Lash TL, Gogineni K, Janssen EAM and McCullough LE: Crown-like structures in breast adipose tissue: Early evidence and current issues in breast cancer. Cancers (Basel). 13:22222021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang L: The role of mesenchymal stem cells in modulating the breast cancer microenvironment. Cell Transplant. 32:96368972312200732023. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng J and Hao H: The importance of cancer-associated fibroblasts in targeted therapies and drug resistance in breast cancer. Front Oncol. 13:13338392023. View Article : Google Scholar : PubMed/NCBI | |
|
Rubinstein-Achiasaf L, Morein D, Ben-Yaakov H, Liubomirski Y, Meshel T, Elbaz E, Dorot O, Pichinuk E, Gershovits M, Weil M and Ben-Baruch A: Persistent inflammatory stimulation drives the conversion of MSCs to inflammatory CAFs that promote pro-metastatic characteristics in breast cancer cells. Cancers (Basel). 13:14722021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Y, Yu D, Qian H, Shi Y and Tao Z: CD8+ T cell-based cancer immunotherapy. J Transl Med. 22:3942024. View Article : Google Scholar : PubMed/NCBI | |
|
Bhandarkar V, Dinter T and Spranger S: Architects of immunity: How dendritic cells shape CD8+ T cell fate in cancer. Sci Immunol. 10:eadf47262025. View Article : Google Scholar : PubMed/NCBI | |
|
Giles JR, Globig AM, Kaech SM and Wherry EJ: CD8+ T cells in the cancer-immunity cycle. Immunity. 56:2231–2253. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Tang D, Tang Q, Huang W, Zhang Y, Tian Y and Fu X: Fasting: From physiology to pathology. Adv Sci (Weinh). 10:e22044872023. View Article : Google Scholar : PubMed/NCBI | |
|
Wilkinson MJ, Manoogian ENC, Zadourian A, Lo H, Fakhouri S, Shoghi A, Wang X, Fleischer JG, Navlakha S, Panda S and Taub PR: Ten-hour time-restricted eating reduces weight, blood pressure, and atherogenic lipids in patients with metabolic syndrome. Cell Metab. 31:92–104.e5. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yelek C, Mignion L, Paquot A, Bouzin C, Corbet C, Muccioli GG, Cani PD and Jordan BF: Tumor metabolism is affected by obesity in preclinical models of triple-negative breast cancer. Cancers (Basel). 14:5622022. View Article : Google Scholar : PubMed/NCBI | |
|
James FR, Wootton S, Jackson A, Wiseman M, Copson ER and Cutress RI: Obesity in breast cancer-what is the risk factor? Eur J Cancer. 51:705–720. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ng WH, Abu Zaid Z, Mohd Yusof BN, Amin Nordin S and Lim PY: Association between dietary inflammatory index and body fat percentage among newly diagnosed breast cancer patients. Ann Med. 55:23033992023. View Article : Google Scholar : PubMed/NCBI | |
|
Savva C, Copson E, Johnson PWM, Cutress RI and Beers SA: Obesity is associated with immunometabolic changes in adipose tissue that may drive treatment resistance in breast cancer: immune-metabolic reprogramming and novel therapeutic strategies. Cancers (Basel). 15:24402023. View Article : Google Scholar : PubMed/NCBI | |
|
Calle EE and Kaaks R: Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 4:579–591. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Gallagher EJ and LeRoith D: Obesity and diabetes: The increased risk of cancer and cancer-related mortality. Physiol Rev. 95:727–748. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, et al: Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity. Cell. 183:1848–1866.e26. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Quail DF and Dannenberg AJ: The obese adipose tissue microenvironment in cancer development and progression. Nat Rev Endocrinol. 15:139–154. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Iyengar NM, Gucalp A, Dannenberg AJ and Hudis CA: Obesity and cancer mechanisms: Tumor microenvironment and inflammation. J Clin Oncol. 34:4270–4276. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Fortner RT, Katzke V, Kühn T and Kaaks R: Obesity and breast cancer. Recent Results Cancer Res. 208:43–65. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Jiralerspong S and Goodwin PJ: Obesity and breast cancer prognosis: Evidence, challenges, and opportunities. J Clin Oncol. 34:4203–4216. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Suzuki R, Orsini N, Saji S, Key TJ and Wolk A: Body weight and incidence of breast cancer defined by estrogen and progesterone receptor status-a meta-analysis. Int J Cancer. 124:698–712. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Cecchini RS, Costantino JP, Cauley JA, Cronin WM, Wickerham DL, Land SR, Weissfeld JL and Wolmark N: Body mass index and the risk for developing invasive breast cancer among high-risk women in NSABP P-1 and STAR breast cancer prevention trials. Cancer Prev Res (Phila). 5:583–592. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Chan DSM, Vieira AR, Aune D, Bandera EV, Greenwood DC, McTiernan A, Navarro Rosenblatt D, Thune I, Vieira R and Norat T: Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol. 25:1901–1914. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE Jr, Falk RT, Miller R, et al: Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst. 95:1218–1226. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
He M, Xu S, Yan F, Ruan J and Zhang X: Fatty acid metabolism: A new perspective in breast cancer precision therapy. Front Biosci (Landmark Ed). 28:3482023. View Article : Google Scholar : PubMed/NCBI | |
|
Guo R, Chen Y, Borgard H, Jijiwa M, Nasu M, He M and Deng Y: The function and mechanism of lipid molecules and their roles in the diagnosis and prognosis of breast cancer. Molecules. 25:48682020. View Article : Google Scholar | |
|
Lu S and Archer MC: Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells. Int J Cancer. 126:416–425. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Martin-Perez M, Urdiroz-Urricelqui U, Bigas C and Benitah SA: The role of lipids in cancer progression and metastasis. Cell Metab. 34:1675–1699. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Solsona-Vilarrasa E and Vousden KH: Obesity, white adipose tissue and cancer. FEBS J. 292:2189–2207. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, et al: Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Oncogene. 38:2351–2363. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Magalhães A, Cesário V, Coutinho D, Matias I, Domingues G, Pinheiro C, Serafim T and Dias S: A high-cholesterol diet promotes the intravasation of breast tumor cells through an LDL-LDLR axis. Sci Rep. 14:94712024. View Article : Google Scholar : PubMed/NCBI | |
|
Zipinotti Dos Santos D, de Souza JC, Pimenta TM, da Silva Martins B, Junior RSR, Butzene SMS, Tessarolo NG, Cilas PML Jr, Silva IV and Rangel LBA: The impact of lipid metabolism on breast cancer: A review about its role in tumorigenesis and immune escape. Cell Commun Signal. 21:1612023. View Article : Google Scholar : PubMed/NCBI | |
|
Centonze G, Natalini D, Piccolantonio A, Salemme V, Morellato A, Arina P, Riganti C and Defilippi P: Cholesterol and its derivatives: Multifaceted players in breast cancer progression. Front Oncol. 12:9066702022. View Article : Google Scholar : PubMed/NCBI | |
|
Li P, Zhang Z, Lv H and Sun P: Inhibiting the expression of STARD3 induced apoptosis via the inactivation of PI3K/AKT/mTOR pathway on ER+ breast cancer. Tissue Cell. 79:1019712022. View Article : Google Scholar : PubMed/NCBI | |
|
Bandyopadhayaya S, Akimov MG, Verma R, Sharma A, Sharma D, Kundu GC, Gretskaya NM, Bezuglov VV and Mandal CC: N-arachidonoyl dopamine inhibits epithelial-mesenchymal transition of breast cancer cells through ERK signaling and decreasing the cellular cholesterol. J Biochem Mol Toxicol. 35:e226932021. View Article : Google Scholar : PubMed/NCBI | |
|
Baek AE, Krawczynska N, Das Gupta A, Dvoretskiy SV, You S, Park J, Deng YH, Sorrells JE, Smith BP, Ma L, et al: The cholesterol metabolite 27HC increases secretion of extracellular vesicles which promote breast cancer progression. Endocrinology. 162:bqab0952021. View Article : Google Scholar : PubMed/NCBI | |
|
Godina C, Indira Chandran V, Barbachowska M, Tryggvadottir H, Nodin B, Visse E, Borgquist S, Jirström K, Isaksson K, Bosch A, et al: Interplay between caveolin-1 and body and tumor size affects clinical outcomes in breast cancer. Transl Oncol. 22:1014642022. View Article : Google Scholar : PubMed/NCBI | |
|
Trabert B, Bauer DC, Buist DSM, Cauley JA, Falk RT, Geczik AM, Gierach GL, Hada M, Hue TF, Lacey JV Jr, et al: Association of circulating progesterone with breast cancer risk among postmenopausal women. JAMA Netw Open. 3:e2036452020. View Article : Google Scholar : PubMed/NCBI | |
|
Mohanty SS and Mohanty PK: Obesity as potential breast cancer risk factor for postmenopausal women. Genes Dis. 8:117–123. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Glassman I, Le N, Asif A, Goulding A, Alcantara CA, Vu A, Chorbajian A, Mirhosseini M, Singh M and Venketaraman V: The role of obesity in breast cancer pathogenesis. Cells. 12:20612023. View Article : Google Scholar : PubMed/NCBI | |
|
Dong S, Wang Z, Shen K and Chen X: Metabolic syndrome and breast cancer: Prevalence, treatment response, and prognosis. Front Oncol. 11:6296662021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao X, An X, Yang C, Sun W, Ji H and Lian F: The crucial role and mechanism of insulin resistance in metabolic disease. Front Endocrinol (Lausanne). 14:11492392023. View Article : Google Scholar : PubMed/NCBI | |
|
Dieli-Conwright CM, Wong L, Waliany S and Mortimer JE: Metabolic syndrome and breast cancer survivors: A follow-up analysis after completion of chemotherapy. Diabetol Metab Syndr. 14:362022. View Article : Google Scholar : PubMed/NCBI | |
|
Viedma-Rodríguez R, Martínez-Hernández MG, Martínez-Torres DI and Baiza-Gutman LA: Epithelial mesenchymal transition and progression of breast cancer promoted by diabetes mellitus in mice are associated with increased expression of glycolytic and proteolytic enzymes. Horm Cancer. 11:170–181. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Rahman MM, Behl T, Islam MR, Alam MN, Islam MM, Albarrati A, Albratty M, Meraya AM and Bungau SG: Emerging management approach for the adverse events of immunotherapy of cancer. Molecules. 27:37982022. View Article : Google Scholar : PubMed/NCBI | |
|
Mehanna J, Haddad FG, Eid R, Lambertini M and Kourie HR: Triple-negative breast cancer: Current perspective on the evolving therapeutic landscape. Int J Womens Health. 11:431–437. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ye F, Dewanjee S, Li Y, Jha NK, Chen ZS, Kumar A, Vishakha Behl T, Jha SK and Tang H: Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer. Mol Cancer. 22:1052023. View Article : Google Scholar : PubMed/NCBI | |
|
Morrow RJ, Allam AH, Yeo B, Deb S, Murone C, Lim E, Johnstone CN and Ernst M: Paracrine IL-6 signaling confers proliferation between heterogeneous inflammatory breast cancer sub-clones. Cancers (Basel). 14:22922022. View Article : Google Scholar : PubMed/NCBI | |
|
Manore SG, Doheny DL, Wong GL and Lo HW: IL-6/JAK/STAT3 signaling in breast cancer metastasis: Biology and treatment. Front Oncol. 12:8660142022. View Article : Google Scholar : PubMed/NCBI | |
|
Ding R, Kan Q, Wang T, Xiao R, Song Y and Li D: Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway. Front Pharmacol. 15:14838962025. View Article : Google Scholar : PubMed/NCBI | |
|
Sun X, Liu K, Lu S, He W and Du Z: Targeted therapy and immunotherapy for heterogeneous breast cancer. Cancers (Basel). 14:54562022. View Article : Google Scholar : PubMed/NCBI | |
|
Swain SM, Shastry M and Hamilton E: Targeting HER2-positive breast cancer: Advances and future directions. Nat Rev Drug Discov. 22:101–126. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Maadi H, Soheilifar MH, Choi WS, Moshtaghian A and Wang Z: Trastuzumab mechanism of action; 20 years of research to unravel a dilemma. Cancers (Basel). 13:35402021. View Article : Google Scholar : PubMed/NCBI | |
|
Li F and Liu S: Focusing on NK cells and ADCC: A promising immunotherapy approach in targeted therapy for HER2-positive breast cancer. Front Immunol. 13:10834622022. View Article : Google Scholar : PubMed/NCBI | |
|
Mandó P, Rivero SG, Rizzo MM, Pinkasz M and Levy EM: Targeting ADCC: A different approach to HER2 breast cancer in the immunotherapy era. Breast. 60:15–25. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Waks AG, Martínez-Sáez O, Tarantino P, Braso-Maristany F, Pascual T, Cortés J, Tolaney SM and Prat A: Dual HER2 inhibition: Mechanisms of synergy, patient selection, and resistance. Nat Rev Clin Oncol. 21:818–832. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Yeh R, O'Donoghue JA, Jayaprakasam VS, Mauguen A, Min R, Park S, Brockway JP, Bromberg JF, Zhi WI, Robson ME, et al: First-in-human evaluation of site-specifically labeled 89Zr-pertuzumab in patients with HER2-positive breast cancer. J Nucl Med. 65:386–393. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
García-Aranda M and Redondo M: Protein kinase targets in breast cancer. Int J Mol Sci. 18:25432017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang S, Chen W, Zhou J, Liang Q, Zhang Y, Su M, Zhang Z and Qu J: The benefits and safety of monoclonal antibodies: implications for cancer immunotherapy. J Inflamm Res. 18:4335–4357. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Wang R, Hu B, Pan Z, Mo C, Zhao X, Liu G, Hou P, Cui Q, Xu Z, Wang W, et al: Antibody-drug conjugates (ADCs): Current and future biopharmaceuticals. J Hematol Oncol. 18:512025. View Article : Google Scholar : PubMed/NCBI | |
|
Torres ETR and Emens LA: Emerging combination immunotherapy strategies for breast cancer: Dual immune checkpoint modulation, antibody-drug conjugates and bispecific antibodies. Breast Cancer Res Treat. 191:291–302. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H, Diéras V, Hegg R, Im SA, Shaw Wright G, et al: Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer. N Engl J Med. 379:2108–2121. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Cortes J, Cescon DW, Rugo HS, Nowecki Z, Im SA, Yusof MM, Gallardo C, Lipatov O, Barrios CH, Holgado E, et al: Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): A randomised, placebo-controlled, double-blind, phase 3 clinical trial. Lancet. 396:1817–1828. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ayoub NM, Al-Shami KM and Yaghan RJ: Immunotherapy for HER2-positive breast cancer: Recent advances and combination therapeutic approaches. Breast Cancer (Dove Med Press). 11:53–69. 2019.PubMed/NCBI | |
|
Mittendorf EA, Zhang H, Barrios CH, Saji S, Jung KH, Hegg R, Koehler A, Sohn J, Iwata H, Telli ML, et al: Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): A randomised, double-blind, phase 3 trial. Lancet. 396:1090–1100. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Pusztai L, Yau C, Wolf DM, Han HS, Du L, Wallace AM, String-Reasor E, Boughey JC, Chien AJ, Elias AD, et al: Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial. Cancer Cell. 39:989–998.e5. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
El Bairi K, Haynes HR, Blackley E, Fineberg S, Shear J, Turner S, de Freitas JR, Sur D, Amendola LC, Gharib M, et al: The tale of TILs in breast cancer: A report from the international immuno-oncology biomarker working group. NPJ Breast Cancer. 7:1502021. View Article : Google Scholar : PubMed/NCBI | |
|
Loi S, Salgado R, Adams S, Pruneri G, Francis PA, Lacroix-Triki M, Joensuu H, Dieci MV, Badve S, Demaria S, et al: Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer. NPJ Breast Cancer. 8:32022. View Article : Google Scholar : PubMed/NCBI | |
|
Moisand A, Madéry M, Boyer T, Domblides C, Blaye C and Larmonier N: Hormone receptor signaling and breast cancer resistance to anti-tumor immunity. Int J Mol Sci. 24:150482023. View Article : Google Scholar : PubMed/NCBI | |
|
Axelrod ML, Cook RS, Johnson DB and Balko JM: Biological consequences of MHC-II expression by tumor cells in cancer. Clin Cancer Res. 25:2392–2402. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Smith PL, Piadel K and Dalgleish AG: Directing T-cell immune responses for cancer vaccination and immunotherapy. Vaccines (Basel). 9:13922021. View Article : Google Scholar : PubMed/NCBI | |
|
Mittendorf EA, Clifton GT, Holmes JP, Schneble E, van Echo D, Ponniah S and Peoples GE: Final report of the phase I/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer patients. Ann Oncol. 25:1735–1742. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Carmichael MG, Benavides LC, Holmes JP, Gates JD, Mittendorf EA, Ponniah S and Peoples GE: Results of the first phase 1 clinical trial of the HER-2/neu peptide (GP2) vaccine in disease-free breast cancer patients: United States military cancer institute clinical trials group study I-04. Cancer. 116:292–301. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
McCarthy PM, Clifton GT, Vreeland TJ, Adams AM, O'Shea AE and Peoples GE: AE37: A HER2-targeted vaccine for the prevention of breast cancer recurrence. Expert Opin Investig Drugs. 30:5–11. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Hu Y, Xue J, Li J, Yi J, Bu J, Zhang Z, Qiu P and Gu X: Advances in immunotherapy for triple-negative breast cancer. Mol Cancer. 22:1452023. View Article : Google Scholar : PubMed/NCBI | |
|
Yuan Y, Lee JS, Yost SE, Frankel PH, Ruel C, Egelston CA, Guo W, Gillece JD, Folkerts M, Reining L, et al: A phase II clinical trial of pembrolizumab and enobosarm in patients with androgen receptor-positive metastatic triple-negative breast cancer. Oncologist. 26:99–e217. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wood SJ, Gao Y, Lee JH, Chen J, Wang Q, Meisel JL and Li X: High tumor infiltrating lymphocytes are significantly associated with pathological complete response in triple negative breast cancer treated with neoadjuvant KEYNOTE-522 chemoimmunotherapy. Breast Cancer Res Treat. 205:193–199. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Cardoso F, O'Shaughnessy J, Liu Z, McArthur H, Schmid P, Cortes J, Harbeck N, Telli ML, Cescon DW, Fasching PA, et al: Pembrolizumab and chemotherapy in high-risk, early-stage, ER+/HER2− breast cancer: A randomized phase 3 trial. Nat Med. 31:442–448. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Thuya WL, Cao Y, Ho PC, Wong AL, Wang L, Zhou J, Nicot C and Goh BC: Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy. Cytokine Growth Factor Rev. 85:26–42. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Kahaer G, Pan S, Yang C, Xie W and Lu Y: Dual function of Gasdermin E: Pyroptosis-mediated pan-cancer suppression versus HCC-specific oncogenic activity. Front Immunol. 16:16263112025. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Xu J, Wang W, Zhang B, Yu X and Shi S: Epigenetic regulation in the tumor microenvironment: Molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. 8:2102023. View Article : Google Scholar : PubMed/NCBI | |
|
Kwon YY and Hui S: IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia. EMBO Rep. 25:2592–2609. 2024. View Article : Google Scholar : PubMed/NCBI |