|
1
|
Hayflick L and Moorhead PS: The serial
cultivation of human diploid cell strains. Exp Cell Res.
25:585–621. 1961. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Campisi J and d'Adda di Fagagna F:
Cellular senescence: When bad things happen to good cells. Nat Rev
Mol Cell Biol. 8:729–740. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ohtani N, Mann DJ and Hara E: Cellular
senescence: Its role in tumor suppression and aging. Cancer Sci.
100:792–797. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Dimri GP, Lee X, Basile G, Acosta M, Scott
G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O,
et al: A biomarker that identifies senescent human cells in culture
and in aging skin in vivo. Proc Natl Acad Sci USA. 92:9363–9367.
1995. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Kuilman T, Michaloglou C, Mooi WJ and
Peeper DS: The essence of senescence. Genes Dev. 24:2463–2479.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Harper JW and Elledge SJ: The DNA damage
response: Ten years after. Mol Cell. 28:739–745. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Mallette FA and Ferbeyre G: The DNA damage
signaling pathway connects oncogenic stress to cellular senescence.
Cell Cycle. 6:1831–1836. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Coppé JP, Desprez PY, Krtolica A and
Campisi J: The senescence-associated secretory phenotype: The dark
side of tumor suppression. Annu Rev Pathol. 5:99–118. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Tchkonia T, Zhu Y, van Deursen J, Campisi
J and Kirkland JL: Cellular senescence and the senescent secretory
phenotype: Therapeutic opportunities. J Clin Invest. 123:966–972.
2013. View
Article : Google Scholar : PubMed/NCBI
|
|
10
|
Muñoz-Espín D, Cañamero M, Maraver A,
Gómez-López G, Contreras J, Murillo-Cuesta S, Rodríguez-Baeza A,
Varela-Nieto I, Ruberte J, Collado M and Serrano M: Programmed cell
senescence during mammalian embryonic development. Cell.
155:1104–1118. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Demaria M, Ohtani N, Youssef SA, Rodier F,
Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé
ME, et al: An essential role for senescent cells in optimal wound
healing through secretion of PDGF-AA. Dev Cell. 31:722–733. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Laberge RM, Awad P, Campisi J and Desprez
PY: Epithelial-mesenchymal transition induced by senescent
fibroblasts. Cancer Microenviron. 5:39–44. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Von Ahrens D, Bhagat TD, Nagrath D, Maitra
A and Verma A: The role of stromal cancer-associated fibroblasts in
pancreatic cancer. J Hematol Oncol. 10:762017. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kawase T, Yasui Y, Nishina S, Hara Y,
Yanatori I, Tomiyama Y, Nakashima Y, Yoshida K, Kishi F, Nakamura M
and Hino K: Fibroblast activation protein-α-expressing fibroblasts
promote the progression of pancreatic ductal adenocarcinoma. BMC
Gastroenterol. 15:1092015. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Tabola R, Zaremba-Czogalla M, Baczynska D,
Cirocchi R, Stach K, Grabowski K and Augoff K: Fibroblast
activating protein-α expression in squamous cell carcinoma of the
esophagus in primary and irradiated tumors: The use of archival
FFPE material for molecular techniques. Eur J Histochem.
61:27932017.PubMed/NCBI
|
|
16
|
Shindo K, Aishima S, Ohuchida K, Fujiwara
K, Fujino M, Mizuuchi Y, Hattori M, Mizumoto K, Tanaka M and Oda Y:
Podoplanin expression in cancer-associated fibroblasts enhances
tumor progression of invasive ductal carcinoma of the pancreas. Mol
Cancer. 12:1682013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Su S, Chen J, Yao H, Liu J, Yu S, Lao L,
Wang M, Luo M, Xing Y, Chen F, et al: CD10+GPR77+ Cancer-associated
fibroblasts promote cancer formation and chemoresistance by
sustaining cancer stemness. Cell. 172:841–856.e16. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Paulsson J, Rydén L, Strell C, Frings O,
Tobin NP, Fornander T, Bergh J, Landberg G, Stål O and Östman A:
High expression of stromal PDGFRβ is associated with reduced
benefit of tamoxifen in breast cancer. J Pathol Clin Res. 3:38–43.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Miyashita T, Tajima H, Makino I, Okazaki
M, Yamaguchi T, Ohbatake Y, Nakanuma S, Hayashi H, Takamura H,
Ninomiya I, et al: Neoadjuvant chemotherapy with gemcitabine plus
nab-paclitaxel reduces the number of cancer-associated fibroblasts
through depletion of pancreatic stroma. Anticancer Res. 38:337–343.
2018.PubMed/NCBI
|
|
20
|
Miyashita T, Tajima H, Gabata R, Okazaki
M, Shimbashi H, Ohbatake Y, Okamoto K, Nakanuma S, Sakai S, Makino
I, et al: Impact of extravasated platelet activation and
podoplanin-positive cancer-associated fibroblasts in pancreatic
cancer stroma. Anticancer Res. 39:5565–5572. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Lee JS, Yoo JE, Kim H, Rhee H, Koh MJ,
Nahm JH, Choi JS, Lee KH and Park YN: Tumor stroma with
senescence-associated secretory phenotype in steatohepatitic
hepatocellular carcinoma. PLoS One. 12:e01719222017. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Harper EI, Sheedy EF and Stack MS: With
great age comes great metastatic ability: Ovarian cancer and the
appeal of the aging peritoneal microenvironment. Cancers (Basel).
10:2302018. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Mori JO, Elhussin I, Brennen WN, Graham
MK, Lotan TL, Yates CC, De Marzo AM, Denmeade SR, Yegnasubramanian
S, Nelson WG, et al: Prognostic and therapeutic potential of
senescent stromal fibroblasts in prostate cancer. Nat Rev Urol.
21:258–273. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Nakayama I: Therapeutic strategy for
scirrhous type gastric cancer. Jpn J Clin Oncol. 55:860–870. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Yamamoto Y, Kasashima H, Fukui Y, Tsujio
G, Yashiro M and Maeda K: The heterogeneity of cancer-associated
fibroblast subpopulations: Their origins, biomarkers, and roles in
the tumor microenvironment. Cancer Sci. 114:16–24. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Ministry of Education Culture Sports
Science Technology Ministry of Health Labour Welfare, Ministry of
Economy, TradeIndustry, . Ethical guidelines for medical and
biological research involving human subjects (In Japanese).
https://www.mhlw.go.jp/content/000757566.pdf2021.
|
|
27
|
Brierley JD, Gospodarowicz MK and
Wittekind C: Union for International Cancer Control (UICC). TNM
Classification of Malignant Tumors. 8th Edition. Wiley-Blackwell;
2017
|
|
28
|
Tsuta K, Wistuba II and Moran CA:
Differential expression of somatostatin receptors 1–5 in
neuroendocrine carcinoma of the lung. Pathol Res Pract.
208:470–474. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Schmid HA, Lambertini C, van Vugt HH,
Barzaghi-Rinaudo P, Schäfer J, Hillenbrand R, Sailer AW, Kaufmann M
and Nuciforo P: Monoclonal antibodies against the human
somatostatin receptor subtypes 1–5: Development and
immunohistochemical application in neuroendocrine tumors.
Neuroendocrinology. 95:232–247. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Roncoroni L, Elli L, Doneda L, Piodi L,
Ciulla MM, Paliotti R and Bardella MT: Isolation and culture of
fibroblasts from endoscopic duodenal biopsies of celiac patients. J
Transl Med. 7:402009. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Seluanov A, Vaidya A and Gorbunova V:
Establishing primary adult fibroblast cultures from rodents. J Vis
Exp. 5:20332010.
|
|
32
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Rasband WS: ImageJ. U.S. National
Institutes of Health. (Bethesda, MD). 2011.http://imagej.nih.gov/ij
|
|
34
|
Hara E, Smith R, Parry D, Tahara H, Stone
S and Peters G: Regulation of p16CDKN2 expression and its
implications for cell immortalization and senescence. Mol Cell
Biol. 16:859–867. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Serrano M, Lin AW, McCurrach ME, Beach D
and Lowe SW: Oncogenic ras provokes premature cell senescence
associated with accumulation of p53 and p16INK4a. Cell. 88:593–602.
1997. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Raimondi S, Lowenfels AB, Morselli-Labate
AM, Maisonneuve P and Pezzilli R: Pancreatic cancer in chronic
pancreatitis; aetiology, incidence, and early detection. Best Pract
Res Clin Gastroenterol. 24:349–358. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Qiu D, Kurosawa M, Lin Y, Inaba Y, Matsuba
T, Kikuchi S, Yagyu K, Motohashi Y and Tamakoshi A; JACC Study
Group, : Overview of the epidemiology of pancreatic cancer focusing
on the JACC study. J Epidemiol. 15 (Suppl II):S157–S167. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Iodice S, Gandini S, Maisonneuve P and
Lowenfels AB: Tobacco and the risk of pancreatic cancer: A review
and meta-analysis. Langenbecks Arch Surg. 393:535–545. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Tramacere I, Scotti L, Jenab M, Bagnardi
V, Bellocco R, Rota M, Corrao G, Bravi F, Boffetta P and La Vecchia
C: Alcohol drinking and pancreatic cancer risk: A meta-analysis of
the dose-risk relation. Int J Cancer. 126:1474–1486. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Gosavi R, Jaya J, Yap R, Narasimhan V and
Ooi G: Obesity and gastrointestinal cancer: A converging epidemic
with surgical consequence. Eur J Surg Oncol. 51:1103582025.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Cuomo RE: Distinct somatic mutation
profiles in colon cancer by behavioral comorbidity. Future Sci OA.
11:25615012025. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Wang J, Qiu K, Zhou S, Gan Y, Jiang K,
Wang D and Wang H: Risk factors for hepatocellular carcinoma: An
umbrella review of systematic review and meta-analysis. Ann Med.
57:24555392025. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Ni L, Liu Z, Xiang L, Li Y and Zhang Y:
Comprehensive evaluation of risk factors for LNM and distant
metastasis in patients with NSCLC. Sci Rep. 15:308092025.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Min SK, You Y, Choi DW, Han IW, Shin SH,
Yoon S, Jung JH, Yoon SJ and Heo JS: Prognosis of pancreatic head
cancer with different patterns of lymph node metastasis. J
Hepatobiliary Pancreat Sci. 29:1004–1013. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Nurmik M, Ullmann P, Rodriguez F, Haan S
and Letellier E: In search of definitions: Cancer-associated
fibroblasts and their markers. Int J Cancer. 146:895–905. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Ohtani N, Imamura Y, Yamakoshi K, Hirota
F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T,
et al: Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent
kinase inhibitor expression in living animals. Proc Natl Acad Sci
USA. 104:15034–15039. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Kuilman T, Michaloglou C, Vredeveld LC,
Douma S, van Doorn R, Desmet CJ, Aarden LA, Mooi WJ and Peeper DS:
Oncogene-induced senescence relayed by an interleukin-dependent
inflammatory network. Cell. 133:1019–1031. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Ancrile B, Lim KH and Counter CM:
Oncogenic Ras-induced secretion of IL6 is required for
tumorigenesis. Genes Dev. 21:1714–1719. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Coppé JP, Patil CK, Rodier F, Sun Y, Munoz
DP, Goldstein J, Nelson PS, Desprez PY and Campisi J:
Senescence-associated secretory phenotypes reveal
cell-nonautonomous functions of oncogenic RAS and the p53 tumor
suppressor. PLoS Biol. 6:2853–2868. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Lu SY, Chang KW, Liu CJ, Tseng YH, Lu HH,
Lee SY and Lin SC: Ripe areca nut extract induces G1 phase arrests
and senescence-associated phenotypes in normal human oral
keratinocyte. Carcinogenesis. 27:1273–1284. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Sarkar D, Lebedeva IV, Emdad L, Kang DC,
Baldwin AS Jr and Fisher PB: Human polynucleotide phosphorylase
(hPNPaseold-35): A potential link between aging and inflammation.
Cancer Res. 64:7473–7478. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Holmer R, Goumas FA, Waetzig GH, Rose-John
S and Kalthoff H: Interleukin-6: A villain in the drama of
pancreatic cancer development and progression. Hepatobiliary
Pancreat Dis Int. 13:371–380. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Song M, Tang Y, Cao K, Qi L and Xie K:
Unveiling the role of interleukin-6 in pancreatic cancer occurrence
and progression. Front Endocrinol (Lausanne). 15:14083122024.
View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Ara T and Declerck YA: Interleukin-6 in
bone metastasis and cancer progression. Eur J Cancer. 46:1223–1231.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Omori S, Wang TW, Johmura Y, Kanai T,
Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, et al:
Generation of a p16 reporter mouse and its use to characterize and
target p16high cells in vivo. Cell Metab. 32:814–828.e6.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Hickson LJ, Langhi Prata LGP, Bobart SA,
Evans TK, Giorgadze N, Hashmi SK, Herrmann SM, Jensen MD, Jia Q,
Jordan KL, et al: Senolytics decrease senescent cells in humans:
Preliminary report from a clinical trial of dasatinib plus
quercetin in individuals with diabetic kidney disease.
EBiomedicine. 47:446–456. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Farr JN, Atkinson EJ, Achenbach SJ,
Volkman TL, Tweed AJ, Vos SJ, Ruan M, Sfeir J, Drake MT, Saul D, et
al: Effects of intermittent senolytic therapy on bone metabolism in
postmenopausal women: A phase 2 randomized controlled trial. Nat
Med. 30:2605–2612. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Bussian TJ, Aziz A, Meyer CF, Swenson BL,
van Deursen JM and Baker DJ: Clearance of senescent glial cells
prevents tau-dependent pathology and cognitive decline. Nature.
562:578–582. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Childs BG, Baker DJ, Wijshake T, Conover
CA, Campisi J and van Deursen JM: Senescent intimal foam cells are
deleterious at all stages of atherosclerosis. Science. 354:472–477.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Paez-Ribes M, González-Gualda E, Doherty
GJ and Muñoz-Espín D: Targeting senescent cells in translational
medicine. EMBO Mol Med. 11:e102342019. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Baar MP, Brandt RMC, Putavet DA, Klein
JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van
Willigenburg H, Feijtel DA, et al: Targeted apoptosis of senescent
cells restores tissue homeostasis in response to chemotoxicity and
aging. Cell. 169:132–147.e16. 2017. View Article : Google Scholar : PubMed/NCBI
|
