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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April-2026 Volume 55 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Epigenetics

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Review Open Access

Advances in isolation and detection technologies and immunotherapy applications of circulating tumor cells (Review)

  • Authors:
    • Ping Zhou
    • Qin Ye
    • Yiyun Huang
    • Yumei Feng
    • Li Zhou
    • Ke Xie

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P.R. China, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 57
    |
    Published online on: January 28, 2026
       https://doi.org/10.3892/or.2026.9062
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Abstract

Circulating tumor cells (CTCs) are shed from the primary tumor into the peripheral bloodstream, where they play crucial roles in tumor metastasis and recurrence. As a cornerstone of liquid biopsy, CTCs hold significant potential for early tumor diagnosis, therapeutic response monitoring, and prognosis. However, the rarity and heterogeneity of CTCs pose considerable challenges for their isolation and enrichment. Additionally, their predictive usefulness in tumor immunotherapy remains relatively limited. The present review summarizes recent advancements in CTC isolation and detection technologies, explores their clinical applications in immunotherapy, and discusses current challenges alongside potential strategies for improvement. The integration of these technologies into clinical practice could pave the way for more personalized and precise cancer treatment strategies in the future.

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Copy and paste a formatted citation
Spandidos Publications style
Zhou P, Ye Q, Huang Y, Feng Y, Zhou L and Xie K: <p>Advances in isolation and detection technologies and immunotherapy applications of circulating&nbsp;tumor cells (Review)</p>. Oncol Rep 55: 57, 2026.
APA
Zhou, P., Ye, Q., Huang, Y., Feng, Y., Zhou, L., & Xie, K. (2026). <p>Advances in isolation and detection technologies and immunotherapy applications of circulating&nbsp;tumor cells (Review)</p>. Oncology Reports, 55, 57. https://doi.org/10.3892/or.2026.9062
MLA
Zhou, P., Ye, Q., Huang, Y., Feng, Y., Zhou, L., Xie, K."<p>Advances in isolation and detection technologies and immunotherapy applications of circulating&nbsp;tumor cells (Review)</p>". Oncology Reports 55.4 (2026): 57.
Chicago
Zhou, P., Ye, Q., Huang, Y., Feng, Y., Zhou, L., Xie, K."<p>Advances in isolation and detection technologies and immunotherapy applications of circulating&nbsp;tumor cells (Review)</p>". Oncology Reports 55, no. 4 (2026): 57. https://doi.org/10.3892/or.2026.9062
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou P, Ye Q, Huang Y, Feng Y, Zhou L and Xie K: <p>Advances in isolation and detection technologies and immunotherapy applications of circulating&nbsp;tumor cells (Review)</p>. Oncol Rep 55: 57, 2026.
APA
Zhou, P., Ye, Q., Huang, Y., Feng, Y., Zhou, L., & Xie, K. (2026). <p>Advances in isolation and detection technologies and immunotherapy applications of circulating&nbsp;tumor cells (Review)</p>. Oncology Reports, 55, 57. https://doi.org/10.3892/or.2026.9062
MLA
Zhou, P., Ye, Q., Huang, Y., Feng, Y., Zhou, L., Xie, K."<p>Advances in isolation and detection technologies and immunotherapy applications of circulating&nbsp;tumor cells (Review)</p>". Oncology Reports 55.4 (2026): 57.
Chicago
Zhou, P., Ye, Q., Huang, Y., Feng, Y., Zhou, L., Xie, K."<p>Advances in isolation and detection technologies and immunotherapy applications of circulating&nbsp;tumor cells (Review)</p>". Oncology Reports 55, no. 4 (2026): 57. https://doi.org/10.3892/or.2026.9062
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