|
1
|
Cohen EEW, Bell RB, Bifulco CB, Burtness
B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL,
et al: The society for immunotherapy of cancer consensus statement
on immunotherapy for the treatment of squamous cell carcinoma of
the head and neck (HNSCC). J Immunother Cancer. 7:1842019.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
El-Naggar AK, Chan JKC, Grandis JR, Takata
T and Slootweg PJ: WHO Classification of Head and Neck Tumors. 4th
edition. IARC; Lyon: 2017
|
|
3
|
Sung H, Ferlay J, Siegel RL, Laversanne M,
Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020:
GLOBOCAN estimates of incidence and mortality worldwide for 36
cancers in 185 countries. CA Cancer J Clin. 71:209–249.
2021.PubMed/NCBI
|
|
4
|
Liu JC, Bhayani M, Kuchta K, Galloway T
and Fundakowski C: Patterns of distant metastasis in head and neck
cancer at presentation: Implications for initial evaluation. Oral
Oncol. 88:131–136. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ferris RL, Blumenschein G Jr, Fayette J,
Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE,
Even C, et al: Nivolumab for recurrent squamous-cell carcinoma of
the head and neck. N Engl J Med. 375:1856–1867. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Harrington KL, Burtness B, Greil R,
Soulières D, Tahara M, de Castro G Jr, Psyrri A, Brana I, Basté N,
Neupane P, et al: Pembrolizumab with or without chemotherapy in
recurrent or metastatic head and neck squamous cell carcinoma:
Updated results of the phase III KEYNOTE-048 study. J Clin Oncol.
41:790–802. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Morad G, Helmink BA, Sharma P and Wargo
JA: Hallmarks of response, resistance, and toxicity to immune
checkpoint blockade. Cell. 184:5309–5337. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Elhanani O, Ben-Uri R and Keren L: Spatial
profiling technologies illuminate the tumor microenvironment.
Cancer Cell. 41:404–420. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Yang K, Wang X, Song C, He Z, Wang R, Xu
Y, Jiang Y, Wan Y, Mei J and Mao W: The role of lipid metabolic
reprogramming in tumor microenvironment. Theranostics.
13:1774–1808. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Chen X and Song E: Turning foes to
friends: Targeting cancer- associated fibroblasts. Nat Rev Drug
Discov. 18:99–115. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Mao X, Xu J, Wang W, Liang C, Hua J, Liu
J, Zhang B, Meng Q, Yu X and Shi S: Crosstalk between
cancer-associated fibroblasts and immune cells in the tumor
microenvironment: New findings and future perspectives. Mol Cancer.
20:1312021. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Barrett R and Puré E: Cancer-associated
fibroblasts: Key determinants of tumor immunity and immunotherapy.
Curr Opin Immunol. 64:80–87. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Deng Y, Cheng J, Fu B, Liu W, Chen G,
Zhang Q and Yang Y: Hepatic carcinoma-associated fibroblasts
enhance immune suppression by facilitating the generation of
myeloid-derived suppressor cells. Oncogene. 36:1090–1101. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Hsu CY, Saleh RO, Mohammed JS, Mansuri N,
Rekha MM, Anand A, Sahoo S, Zwamel SS, Zwamel AH and Hulail HM: The
dynamic interplay between melanoma cells and CAFs: Implications
drug resistance and immune evasion and possible therapeutics. Exp
Cell Res. 449:1145812025. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Wein L, Luen SJ, Savas P, Salgado R and
Loi S: Checkpoint blockade in the treatment of breast cancer:
Current status and future directions. Br J Cancer. 119:4–11. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Loi S, Michiels S, Adams S, Loibl S,
Budczies J, Denkert C and Salgado R: The journey of
tumor-infiltrating lymphocytes as a biomarker in breast cancer:
Clinical utility in an era of checkpoint inhibition. Ann Oncol.
32:1236–1244. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Kieffer Y, Hocine HR, Gentric G, Pelon F,
Bernard C, Bourachot B, Lameiras S, Albergante L, Bonneau C, Guyard
A, et al: Single-cell analysis reveals fibroblast clusters linked
to immunotherapy resistance in cancer. Cancer Discov. 10:1330–1351.
2020. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Miyai Y, Sugiyama D, Hase T, Asai N, Taki
T, Nishida K, Fukui T, Chen-Yoshikawa TF, Kobayashi H, Mii S, et
al: Meflin-positive cancer-associated fibroblasts enhance tumor
response to immune checkpoint blockade. Life Sci Alliance.
5:e2021012302022. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Krishnamurty AT, Shyer JA, Thai M, Gandham
V, Buechler MB, Yang YA, Pradhan RN, Wang AW, Sanchez PL, Qu Y, et
al: LRRC15+ myofibroblasts dictate the stromal setpoint
to suppress tumour immunity. Nature. 611:148–154. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Galbo PM Jr, Zang X and Zheng D: Molecular
features of cancer-associated fibroblast subtypes and their
implication on cancer pathogenesis, prognosis, and immunotherapy
resistance. Clin Cancer Res. 27:2636–2647. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wang LX, Zhang SX, Wu HJ, Rong XL and Guo
J: M2b macrophage polarization and its roles in diseases. J Leukoc
Biol. 106:345–358. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Funes SC, Rios M, Escobar-Vera J and
Kalergis AM: Implications of macrophage polarization in
autoimmunity. Immunology. 154:186–195. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Mehraj U, Dar AH, Wani NA and Mir MA:
Tumor microenvironment promotes breast cancer chemoresistance.
Cancer Chemother Pharmacol. 87:147–158. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Jin X, Deng Q, Ye S, Liu S, Fu Y, Liu Y,
Wu G, Ouyang G and Wu T: Cancer-associated fibroblast-derived
periostin promotes papillary thyroid tumor growth through
integrin-FAK-STAT3 signaling. Theranostics. 14:3014–3028. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Zhu M, Fejzo MS, Anderson L, Dering J,
Ginther C, Ramos L, Gasson JC, Karlan BY and Slamon DJ: Periostin
promotes ovarian cancer angiogenesis and metastasis. Gynecol Oncol.
119:337–344. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Contié S, Voorzanger-Rousselot N, Litvin
J, Clézardin P and Garnero P: Increased expression and serum levels
of the stromal cellsecreted protein periostin in breast cancer bone
metastases. Int J Cancer. 128:352–360. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Ryner L, Guan Y, Firestein R, Xiao Y, Choi
Y, Rabe C, Lu S, Fuentes E, Huw LY, Lackner MR, et al: Upregulation
of periostin and reactive stroma is associated with primary
chemoresistance and predicts clinical outcomes in epithelial
ovarian cancer. Clin Cancer Res. 21:2941–2951. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Jeong JY, Jeong W and Kim HJ: Promotion of
chondrosarcoma cell survival, migration and lymphangiogenesis by
periostin. Anticancer Res. 40:5463–5469. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Zhou W, Ke SQ, Huang Z, Flavahan W, Fang
X, Paul J, Wu L, Sloan AE, McLendon RE, Li X, et al: Periostin
secreted by glioblastoma stem cells recruits M2 tumourassociated
macrophages and promotes malignant growth. Nat Cell Biol.
17:170–182. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Tang M, Liu B, Bu X and Zhao P: Crosstalk
between ovarian cancer cells and macrophages through periostin
promotes macrophage recruitment. Cancer Sci. 109:1309–1318. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang H, Liang Y, Liu Z, Zhang R, Chao J,
Wang M, Liu M, Qiao L, Xuan Z, Zhao H and Lu L: POSTN+
cancer-associated fibroblasts determine the efficacy of
immunotherapy in hepatocellular carcinoma. J Immunother Cancer.
12:e0087212024. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Chen C, Guo Q, Liu Y, Hou Q, Liao M, Guo
Y, Zang Y, Wang F, Liu H, Luan X, et al: Single-cell and spatial
transcriptomics reveal POSTN+ cancer-associated
fibroblasts correlated with immune suppression and tumour
progression in non-small cell lung cancer. Clin Transl Med.
13:e15152023. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
van Niel G, D'Angelo G and Raposo G:
Shedding light on the cell biology of extracellular vesicles. Nat
Rev Mol Cell Biol. 19:213–228. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Welsh JA, Goberdhan DCI, O'Driscoll L,
Buzas EI, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Deiedonks
TAP, Erdbrügger U, et al: Minimal information for studies of
extracellular vesicles (MISEV2023): From basic to advanced
approaches. J Extracell Vesicles. 13:e124042024. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Théry C, Witwer KW, Aikawa E, Alcaraz MJ,
Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F,
Atkin-Smith GK, et al: Minimal information for studies of
extracellular vesicles 2018 (MISEV2018): A position statement of
the international society for extracellular vesicles and update of
the MISEV2014 guidelines. J Extracell Vesicles. 7:15357502018.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
You T, Tang H, Wu W, Gao J, Li X, Li N, Xu
X, Xing J, Ge H, Xiao Y, et al: POSTN secretion by extracellular
matrix cancer-associated fibroblasts (eCAFs) correlates with poor
ICB response via macrophage chemotaxis activation of Akt signaling
pathway in gastric cancer. Aging Dis. 14:2177–2192. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Liu X, Li H, Wang Y, Zhang Q, Liu Y and
Liu T: LOX+ iCAFs in HNSCC have the potential to predict
prognosis and immunotherapy responses revealed by single cell RNA
sequencing analysis. Sci Rep. 15:70282025. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Ruffin AT, Cillo AR, Tabib T, Liu A, Onkar
S, Kunning SR, Lampenfeld C, Atiya HI, Abecassis I, Kürten CHL, et
al: B cell signatures and tertiary lymphoid structures contribute
to outcome in head and neck squamous cell carcinoma. Nat Commun.
12:33492021. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Cillo AR, Kürten CHL, Tabib T, Qi Z, Onkar
S, Wang T, Liu A, Duvvuri U, Kim S, Soose RJ, et al: Immune
landscape of viral- and carcinogen-driven head and neck cancer.
Immunity. 52:183–199.e9. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Sung BH, Ketova T, Hoshino D, Zijlstra A
and Weaver AM: Directional cell movement through tissues is
controlled by exosome secretion. Nat Commun. 6:71642015. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-delta delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Wang L, Feng Z, Wang X, Wang X and Zhang
X: DEGseq: An R package for identifying differentially expressed
genes from RNA-seq data. Bioinformatics. 26:136–138. 2019.
View Article : Google Scholar
|
|
43
|
Xie C, Mao X, Huang J, Ding Y, Wu J, Dong
S, Kong L, Gao G, Li CY and Wei L: KOBAS 2.0: A web server for
annotation and identification of enriched pathways and diseases.
Nucleic Acids Res. 39:W316–W322. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Hong HY, Hwang DY, Yang CC, Cheng SM, Chen
PC, Aala WJ, I-Chen Harn H, Evans ST, Onoufriadis A, Liu SL, et al:
Profibrotic subsets of SPP1+ macrophages and
POSTN+ fibroblasts contribute to fibrotic scarring in
acne keloidalis. J Invest Dernatol. 144:1491–1504.e10. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Wu S, Liu M, Zhang M, Ye X, Gu H, Jiang C,
Zhu H, Ye X, Li Q, Huang X and Cao M: The gene expression of CALD1,
CDH2, and POSTN in fibroblast are related to idiopathic pulmonary
fibrosis. Front Immunol. 15:12750642024. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Puram SV, Tirosh I, Parikh AS, Patel AP,
Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, et
al: Single-cell transcriptomic analysis of primary and metastatic
tumor ecosystems in head and neck cancer. Cell. 171:1611–1624.e24.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Buechler MB, Fu W and Turley SJ:
Fibroblast-macrophage reciprocal interactions in health, fibrosis,
and cancer. Immunity. 54:903–915. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Yang AT, Kim YO, Yan XZ, Abe H, Aslam M,
Park KS, Zhao XY, Jia JD, Klein T, You H and Schuppan D: Fibroblast
activation protein activates macrophages and promotes parenchymal
liver inflammation and fibrosis. Cell Mol Gastroenterol Hepatol.
15:841–867. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Martínez VG, Rubio C, Martínez-Fernández
M, Segovia C, López-Calderón F, Garín MI, Teijeira A,
Munera-Maravilla E, Varas A, Sacedón R, et al: BMP4 induces M2
macrophage polarization and favors tumor progression in bladder
cancer. Clin Cancer Res. 23:7388–7399. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Wang Y, Liu S, Li L, Li L, Zhou X, Wan M,
Lou P, Zhao M, Lv K, Yuan Y, et al: Peritoneal M2
macrophage-derived extracellular vesicles as natural multitarget
nanotherapeutics to attenuate cytokine storms after severe
infections. J Control Release. 349:118–132. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Su D, Zhu S, Xu K, Hou Z, Hao F, Xu F, Lin
Y, Zhu Y, Liu D, Duan Q, et al: Phosphoproteomic analysis reveals
changes in A-Raf-related protein phosphorylation in response to
toxoplasma gondii infection in porcine macrophages. Parasit
Vectors. 17:1912024. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Friedman G, Levi-Galibov O, David E,
Bornstein C, Giladi A, Dadiani M, Mayo A, Halperin C,
Pevsner-Fischer M, Lavon H, et al: Cancer-associated fibroblast
compositions change with breast cancer progression linking the
ratio of S100A4+ and PDPN+ CAFs to clinical
outcome. Nat Cancer. 1:692–708. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Bartoschek M, Oskolkov N, Bocci M, Lövrot
J, Larsson C, Sommarin M, Madsen CD, Lindgren D, Pekar G, Karlsson
G, et al: Spatially and functionally distinct subclasses of breast
cancer-associated fibroblasts revealed by single cell RNA
sequencing. Nat Commun. 9:51502018. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Hwang B, Lee JH and Bang D: Single-cell
RNA sequencing technologies and bioinformatics pipelines. Exp Mol
Med. 50:1–14. 2018. View Article : Google Scholar
|
|
55
|
Moncada R, Barkley D, Wagner F, Chiodin M,
Devlin JC, Baron M, Hajdu CH, Simeone DM and Yanai I: Integrating
microarray-based spatial transcriptomics and single-cell RNA-seq
reveals tissue architecture in pancreatic ductal adenocarcinomas.
Nat Biotechnol. 38:333–342. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Öhlund D, Handly-Santana A, Biffi G,
Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA,
Lee EJ, et al: Distinct populations of inflammatory fibroblasts and
myofibroblasts in pancreatic cancer. J Exp Med. 214:579–596. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Song J, Wei R, Liu C, Zhao Z and Liu X,
Wang Y, Liu F and Liu X: Antigen-presenting cancer associated
fibroblasts enhance antitumor immunity and predict immunotherapy
response. Nat Commun. 16:21752025. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Maia A and Wiemann S: Cancer-associated
fibroblasts: Implications for cancer therapy. Cancers (Basel).
13:35262021. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Daste A, Larroquette M, Gibson N, Lasserre
M and Domblides C: Immunotherapy for head and neck squamous cell
carcinoma: Current status and perspectives. Immunotherapy.
16:187–197. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Aboaid H, Khalid T, Hussain A, Myat YM,
Nanda RK, Srinivasmurthy R, Nguyen K, Jones DT, BigcasJ L and Thein
KZ: Advances and challenges in immunotherapy in head and neck
cancer. Front Immunol. 16:15965832025. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Xing F, Saidou J and Watabe K: Cancer
associated fibroblasts (CAFs) in tumor microenvironment. Front
Biosci (Landmark Ed). 15:166–179. 2021. View Article : Google Scholar
|
|
62
|
Kim I, Choi S, Yoo S, Lee M and Kim IS:
Cancer-associated fibroblasts in the hypoxic tumor
microenvironment. Cancers (Basel). 14:33212022. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Wu Y, Li S, Yu H, Zhang S, Yan L, Guan X,
Xu W, Wang Z, Lv A, Tian X, et al: Integrative single-cell and
spatial transcriptomics analysis reveals ECM-remodeling
cancer-associated fibroblast-derived POSTN as a key mediator in
pancreatic ductal adenocarcinoma progression. Int J Biol Sci.
21:3573–3596. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Liu Y, Dong G, Yu J and Liang P:
Integration of single-cell and spatial transcriptomics reveals
fibroblast subtypes in hepatocellular carcinoma: Spatial
distribution, differentiation trajectories, and therapeutic
potential. J Transl Med. 23:1982025. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Thomas ME, Jie E, Kim AM, Mayberry TG,
Cowan BC, Luechtefeld HD, Wakefield MR and Fang Y: Exploring the
role of antigen-presenting cancer-associated fibroblasts and CD74
on the pancreatic ductal adenocarcinoma tumor microenvironment. Med
Oncol. 42:152024. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Shi Y, Wang J, Huang G, Zhu J, Jian H, Xia
G, Wei Q, Li Y and Yu H: A novel epithelial-mesenchymal transition
gene signature for the immune status and prognosis of
hepatocellular carcinoma. Hepatol Int. 16:906–917. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
67
|
Shi Y, Wang Y, Niu K, Zhang W, Lv Q and
Zhang Y: How CLSPN could demystify its prognostic value and
potential molecular mechanism for hepatocellular carcinoma: A
crosstalk study. Comput Biol Med. 172:1082602024. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Grout JA, Sirven P, Leader AM, Maskey S,
Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, et al:
Spatial positioning and matrix programs of cancer-associated
fibroblasts promote T cell exclusion in human lung tumors. Cancer
Discov. 12:2606–2625. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Dominguez CX, Müller S, Keerthivasan S,
Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW,
Castiglioni A, et al: Single-cell RNA sequencing reveals stromal
evolution into LRRC15+ myofibroblasts as a determinant
of patient response to cancer immunotherapy. Cancer Discov.
10:232–253. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Wenhua S, Tsunematsu T, Umeda M, Tawara H,
Fujiwara N, Mouri Y, Arakaki R, Ishimaru N and Kudo Y: Cancer
cell-derived novel periostin isoform promotes invasion in head and
neck squamous cell carcinoma. Cancer Med. 12:8510–8525. 2023.
View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Bie T and Zhang X: Higher expression of
SPP1 predicts poorer survival outcomes in head and neck cancer. J
Immunol Res. 2021:85695752021. View Article : Google Scholar : PubMed/NCBI
|
|
72
|
Qi J, Sun H, Zhang Y, Wang Z, Xun Z, Li Z,
Ding X, Bao R, Hong L, Jia W, et al: Single-cell and spatial
analysis reveal interaction of FAP+ fibroblasts and
SPP1+ macrophages in colorectal cancer. Nat Commun.
13:17422022. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Khaliq AM, Erdogan C, Kurt Z, Turgut SS,
Grunvald MW, Rand T, Khare S, Borgia JA, Hayden DM, Pappas SG, et
al: Refining colorectal cancer classification and clinical
stratification through a single-cell atlas. Genome Biol.
23:1132022. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Wu J, Dai T, Li Z, Pan M, Zhang W, Chen H,
Qiao L, Lian Q, Liu Y and Chen J: Integrating multi-modal
transcriptomics identifies cellular subtypes with distinct roles in
PDAC progression. Cell Oncol (Dordr). 48:1571–1592. 2025.
View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Oppel F, Gendreizig S, Martinez-Ruiz L,
Florido J, López-Rodríguez A, Pabla H, Loganathan L, Hose L, Kühnel
P, Schmidt P, et al: Mucosa-like differentiation of head and neck
cancer cells is inducible and drives the epigenetic loss of cell
malignancy. Cell Death Dis. 15:7242024. View Article : Google Scholar : PubMed/NCBI
|
|
76
|
Tan B, Shi X, Zhang J, Qin J, Zhang N, Ren
H, Qian M, Siwko S, Carmon K, Liu Q, et al: Inhibition of Rspo-Lgr4
facilitates checkpoint blockade therapy by switching macrophage
polarization. Cancer Res. 7817:4929–4942. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
77
|
Ksiazkiewicz M, Gottfried E, Kreutz M,
Mack M, Hofstaedter F and Kunz-Schughart LA: Importance of
CCL2-CCR2A/2B signaling for monocyte migration into spheroids of
breast cancer-derived fibro blasts. Immunobiology. 215:737–747.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Cohen N, Shani O, Raz Y, Sharon Y, Hoffman
D, Abramovitz L and Erez N: Fibroblasts drive an immunosuppressive
and growth promoting microenvironment in breast cancer via
secretion of Chitinase 3-like 1. Oncogene. 36:4457–4468. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Najafi S, Majidpoor J and Mortezaee K:
Extracellular vesicle-based drug delivery in cancer immunotherapy.
Drug Deliv Transl Res. 13:2790–2806. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Fabre M, Ferrer C, Dominguez-Hormaetxe S,
Bockorny B, Murias L, Seifert O, Eisler SA, Kontermann RE,
Pfizenmaier K, Lee SY, et al: OMTX705, a novel FAP-targeting ADC
demonstrates activity in chemotherapy and pembrolizumab-resistant
solid tumor models. Clin Cancer Res. 26:3420–3430. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
81
|
Wang LC, Lo A, Scholler J, Sun J, Majumdar
RS, Kapoor V, Antzis M, Cotner CE, Johnson LA, Durham AC, et al:
Targeting fibroblast activation protein in tumor stroma with
chimeric antigen receptor T cells can inhibit tumor growth and
augment host immunity without severe toxicity. Cancer Immunol Res.
2:154–166. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
82
|
CNCB-NGDC Members and Partners, . Database
resources of the national genomics data center, China national
center for bioinformation in 2025. Nucleic Acids Res. 53:D30–D44.
2025. View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Zhang S, Chen X, Jin E, Wang A, Chen T,
Zhang X, Zhu J, Dong L, Sun Y, Yu C, et al: The GSA family in 2025:
A broadened sharing platform for multi-omics and multimodal data.
Genomics Proteomics Bioinformatics. 23:qzaf0722025. View Article : Google Scholar : PubMed/NCBI
|
