You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.
I agree
International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.
International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.
Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.
Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.
Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.
Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.
Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.
International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.
Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.
Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.
Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.
An International Open Access Journal Devoted to General Medicine.
![]() |
![]() |
![]() |
![]() |
|
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024.PubMed/NCBI | |
|
Dekker E, Tanis PJ, Vleugels JLA, Kasi PM and Wallace MB: Colorectal cancer. Lancet. 394:1467–1480. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Morris VK, Kennedy EB, Baxter NN, Benson AB III, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, et al: Treatment of metastatic colorectal cancer: ASCO guideline. J Clin Oncol. 41:678–700. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, Cercek A, Smith RA and Jemal A: Colorectal cancer statistics, 2020. CA Cancer J Clin. 70:145–164. 2020.PubMed/NCBI | |
|
Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al: Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Wu A, Ni Y, Zhou Y and Shi J: Emerging dual role of ferroptosis in lung cancer (Review). Oncol Rep. 54:1412025. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Lu S, Wu LL, Yang L, Yang L and Wang J: The diversified role of mitochondria in ferroptosis in cancer. Cell Death Dis. 14:5192023. View Article : Google Scholar : PubMed/NCBI | |
|
Dixon SJ and Olzmann JA: The cell biology of ferroptosis. Nat Rev Mol Cell Bio. 25:424–442. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Guo Q, Zhou L and Xia X: Ferroptosis: A double-edged sword. Cell Death Discov. 10:2652024. View Article : Google Scholar : PubMed/NCBI | |
|
Masci D, Ling L, Yang L, Puxeddu M, Colla C, Coluccia A, Santelli M, Sciò P, Cuřínová P, Ansari MSZ, et al: Ferroptosis induction by a new pyrrole derivative in triple negative breast cancer and colorectal cancer. J Med Chem. 68:17840–17858. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Xia W, Lv Y, Zou Y, Kang Z, Li Z, Tian J, Zhou H, Su W and Zhong J: The role of ferroptosis in colorectal cancer and its potential synergy with immunotherapy. Front Immunol. 15:15267492025. View Article : Google Scholar : PubMed/NCBI | |
|
Neagu AI, Bostan M, Ionescu VA, Gheorghe G, Hotnog CM, Roman V, Mihaila M, Stoica SI, Diaconu CC, Diaconu CC, et al: The impact of the microbiota on the immune response modulation in colorectal cancer. Biomolecules. 15:10052025. View Article : Google Scholar : PubMed/NCBI | |
|
Liu K, Huang L, Qi S, Liu S, Xie W, Du L, Cui J, Zhang X, Zhang B, Liu L, et al: Ferroptosis: The Entanglement between Traditional drugs and nanodrugs in tumor therapy. Adv Healthc Mater. 12:e22030852023. View Article : Google Scholar : PubMed/NCBI | |
|
Schmitt M and Greten FR: The inflammatory pathogenesis of colorectal cancer. Nat Rev Immunol. 21:653–667. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Xie H, Cao C, Shu D, Liu T and Zhang T: The important role of ferroptosis in inflammatory bowel disease. Front Med (Lausanne). 11:14490372024. View Article : Google Scholar : PubMed/NCBI | |
|
Mouawad N, El Jaafari N, El Sibai M and Abi-Habib RJ: Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review). Oncol Rep. 55:242026.PubMed/NCBI | |
|
Ding K, Liu C, Li L, Yang M, Jiang N, Luo S and Sun L: Acyl-CoA synthase ACSL4: An essential target in ferroptosis and fatty acid metabolism. Chin Med J (Engl). 136:2521–2537. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JY, Kim WK, Bae KH, Lee SC and Lee EW: Lipid metabolism and ferroptosis. Biology (Basel). 10:1842021.PubMed/NCBI | |
|
Gündem E, Stehling S, Borchert A and Kuhn H: The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals. J Lipid Res. 66:1007682025. View Article : Google Scholar : PubMed/NCBI | |
|
Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, et al: A guideline on the molecular ecosystem regulating ferroptosis. Nat Cell Biol. 26:1447–1457. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Tesfay L, Paul BT, Konstorum A, Deng Z, Cox AO, Lee J, Furdui CM, Hegde P, Torti FM and Torti SV: Stearoyl-CoA Desaturase 1 protects ovarian cancer cells from ferroptotic cell death. Cancer Res. 79:5355–5366. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Rodencal J, Kim N, He A, Li VL, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Long JZ, et al: Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest. Cell Chem Biol. 31:234–248.e13. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Liang D, Feng Y, Zandkarimi F, Wang H, Zhang Z, Kim J, Cai Y, Gu W, Stockwell BR and Jiang X: Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones. Cell. 186:2748–2764.e22. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Sokol KH, Lee CJ, Rogers TJ, Waldhart A, Ellis AE, Madireddy S, Daniels SR, House RRJ, Ye X, Olesnavich M, et al: Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking. Cell Chem Biol. 32:408–422.e6. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, Rajbhandari P, Stokes ME, Bender HG, Csuka JM, et al: Transferrin receptor is a specific ferroptosis marker. Cell Rep. 30:3411–3423.e7. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu D, Hu Z, Lu J and Yi C: Redox-regulated iron metabolism and ferroptosis in ovarian cancer: Molecular insights and therapeutic opportunities. Antioxidants (Basel). 13:7912024. View Article : Google Scholar : PubMed/NCBI | |
|
Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, et al: MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR-/- mice. Phytomedicine. 128:1554892024. View Article : Google Scholar : PubMed/NCBI | |
|
Brown CW, Amante JJ, Chhoy P, Elaimy AL, Liu H, Zhu LJ, Baer CE, Dixon SJ and Mercurio AM: Prominin2 drives ferroptosis resistance by stimulating iron export. Dev Cell. 51:575–586.e4. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Katsarou A and Pantopoulos K: Basics and principles of cellular and systemic iron homeostasis. Mol Aspects Med. 75:1008662020. View Article : Google Scholar : PubMed/NCBI | |
|
Mancias JD, Wang X, Gygi SP, Harper JW and Kimmelman AC: Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 509:105–109. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu L, Liu Y, Zhou X, He H, Chen N, Qin Y, Sun X, Bian Z, Zhang Q, Mao L and Sun S: Sodium butyrate induces ferroptosis in colorectal cancer cells by promoting NCOA4-FTH1-mediated ferritinophagy. Int Immunopharmacol. 163:1151882025. View Article : Google Scholar : PubMed/NCBI | |
|
Jin B, Zhang Z, Zhang Y, Yang M, Wang C, Xu J, Zhu Y, Mi Y, Jiang J and Sun Z: Ferroptosis and myocardial ischemia-reperfusion: Mechanistic insights and new therapeutic perspectives. Front Pharmacol. 15:14829862024. View Article : Google Scholar : PubMed/NCBI | |
|
Kunji ERS, King MS, Ruprecht JJ and Thangaratnarajah C: The SLC25 carrier family: Important transport proteins in mitochondrial physiology and pathology. Physiology (Bethesda). 35:302–327. 2020.PubMed/NCBI | |
|
She G, Hai XX, Jia LY, Zhang YJ, Ren YJ, Pang ZD, Wu LH, Han MZ, Zhang Y, Li JJ, et al: Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1. Redox Biol. 82:1035972025. View Article : Google Scholar : PubMed/NCBI | |
|
Song Y, Gao M, Wei B, Huang X, Yang Z, Zou J and Guo Y: Mitochondrial ferritin alleviates ferroptosis in a kainic acid-induced mouse epilepsy model by regulating iron homeostasis: Involvement of nuclear factor erythroid 2-related factor 2. CNS Neurosci Ther. 30:e146632024. View Article : Google Scholar : PubMed/NCBI | |
|
Banerjee R, Bintee B, Hegde M, BharathwajChetty B, Alqahtani MS, Abbas M, Alqahtani A, Sethi G, Rangan L, Ma Z and Kunnumakkara AB: Protein iron transporters as potential therapeutic targets in cancer: A review. Int J Biol Macromol. 327((Pt 2)): 1466952025. View Article : Google Scholar : PubMed/NCBI | |
|
Bai S, Guo Y, Qiang J, Dai Q and Yang Y: Research progress on the regulation of ferroptosis in NPC (Review). Oncol Rep. 55:332026.PubMed/NCBI | |
|
Zhao C, Huang X, Wu Z, Sun W, Pan Y and Liu Y: pH-Responsive self-assembled upconversion photosensitizer and RSL3 synergistically induce tumor ferroptosis. J Med Chem. 68:15110–15119. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Tang D, Chen X, Kang R and Kroemer G: Ferroptosis: Molecular mechanisms and health implications. Cell Res. 31:107–125. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, et al: Regulation of ferroptotic cancer cell death by GPX4. Cell. 156:317–331. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Song X, Hao X and Zhu BT: Role of mitochondrial reactive oxygen species in chemically-induced ferroptosis. Free Radical Biol Med. 223:473–492. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Lee J and Roh JL: Selenium and selenoproteins: Key regulators of ferroptosis and therapeutic targets in cancer. J Mol Med (Berl). 103:899–911. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Gao R, Wang J, Huang J, Wang T, Guo L, Liu W, Guan J, Liang D, Meng Q and Pan H: FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications. Apoptosis. 29:1019–1037. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Yang JS, Morris AJ, Kamizaki K, Chen J, Stark J, Oldham WM, Nakamura T, Mishima E, Loscalzo J, Minami Y, et al: ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1. Cell. 188:2569–2585.e20. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Li W, Liang L, Liu S, Yi H and Zhou Y: FSP1: A key regulator of ferroptosis. Trends Mol Med. 29:753–764. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, et al: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 593:586–590. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Deshwal S, Onishi M, Tatsuta T, Bartsch T, Cors E, Ried K, Lemke K, Nolte H, Giavalisco P and Langer T: Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. Nat Cell Biol. 25:246–257. 2023.PubMed/NCBI | |
|
Liu Z, Kang R, Yang N, Pan X, Yang J, Yu H, Deng W, Jia Z, Zhang J and Shen Q: Tetrahydrobiopterin inhibitor-based antioxidant metabolic strategy for enhanced cancer ferroptosis-immunotherapy. J Colloid Interf Sci. 658:100–113. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Du J, Zhu X, Zhang Y, Huang X, Wang X, Yang F, Xia H and Hou J: CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1. Int Immunopharmacol. 143((Pt 3)): 1136172024. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y and Gu W: p53 in ferroptosis regulation: The new weapon for the old guardian. Cell Death Differ. 29:895–910. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R and Gu W: Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 520:57–62. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O and Gu W: ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nat Cell Biol. 21:579–591. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen L, Cai Q, Yang R, Wang H, Ling H, Li T, Liu N, Wang Z, Sun J, Tao T, et al: GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail. Proc Natl Acad Sci USA. 120:e22195851202023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Song XW, Zhang N, Li XH, Wu FC, Wei YA, Xu DL, Xu LF and Yuan FW: Ezetimibe engineered L14-8 suppresses advanced prostate cancer by activating PLK1/TP53-SAT1 -induced ferroptosis. Adv Sci (Weinh). 12:e041922025. View Article : Google Scholar : PubMed/NCBI | |
|
Shin D, Lee J and Roh J: Pioneering the future of cancer therapy: Deciphering the p53-ferroptosis nexus for precision medicine. Cancer Lett. 585:2166452024. View Article : Google Scholar : PubMed/NCBI | |
|
Tarangelo A, Magtanong L, Bieging-Rolett KT, Li Y, Ye J, Attardi LD and Dixon SJ: p53 suppresses metabolic stress-induced ferroptosis in cancer cells. Cell Rep. 22:569–575. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Xie Y, Zhu S, Song X, Sun X, Fan Y, Liu J, Zhong M, Yuan H, Zhang L, Billiar TR, et al: The tumor suppressor p53 limits ferroptosis by blocking DPP4 activity. Cell Rep. 20:1692–1704. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yang X, Liang B, Zhang L, Zhang M, Ma M, Qing L, Yang H, Huang G and Zhao J: Ursolic acid inhibits the proliferation of triple-negative breast cancer stem-like cells through NRF2-mediated ferroptosis. Oncol Rep. 52:942024. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang X, Yu M, Wang WK, Zhu LY, Wang X, Jin HC and Feng LF: The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy. Acta Pharmacol Sin. 45:2229–2240. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Y, Jiang Z and Li X: New insights into crosstalk between Nrf2 pathway and ferroptosis in lung disease. Cell Death Dis. 15:8412024. View Article : Google Scholar : PubMed/NCBI | |
|
Xiang Y, Song X and Long D: Ferroptosis regulation through Nrf2 and implications for neurodegenerative diseases. Arch Toxicol. 98:579–615. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, et al: A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 562:600–604. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Huang C, Zeng Q, Chen J, Wen Q, Jin W, Dai X, Ruan R, Zhong H, Xia Y, Wu Z, et al: TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer. Cell Death Dis. 16:2872025. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Zhang C, Zhou S, Liu S, Li Q, Cheng X, Wang R, Chen B, Li Y and Xi M: RNF217-KEAP1-NRF2 feedback loop confers therapeutic resistance by inhibiting ferroptosis in esophageal squamous cell carcinoma. Drug Resist Update. 83:1012962025. View Article : Google Scholar : PubMed/NCBI | |
|
Xu RC, Sun JL, Wang F, Liu HH, Qi ZR, Shi X, Yu XN, Liu TT, Weng SQ, Dong L, et al: Cathepsin S regulates ferroptosis sensitivity in hepatocellular carcinoma through the KEAP1-NRF2 signaling pathway. Redox Biol. 86:1038152025. View Article : Google Scholar : PubMed/NCBI | |
|
Chang K, Chen Y, Zhang X, Zhang W, Xu N, Zeng B, Wang Y, Feng T, Dai B, Xu F, et al: DPP9 stabilizes NRF2 to suppress ferroptosis and induce sorafenib resistance in clear cell renal cell carcinoma. Cancer Res. 83:3940–3955. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Z, Li R, Hou N, Zhang J, Wang T, Fan P, Ji C, Zhang B, Liu L, Wang Y, et al: PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis. J Immunother Cancer. 11:e0068902023. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Huang P, Lai F, Zhang T, Guan J, Wan H and He Y: Mechanisms of ferritinophagy and ferroptosis in diseases. Mol Neurobiol. 61:1605–1626. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Wu H, Liu Q, Shan X, Gao W and Chen Q: ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4. Autophagy. 19:2062–2077. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang H, Zhang P, Cheng Q, Chang K, Bao L and Yi X: Heme oxygenase-1 (HO-1) depletion promotes ferroptosis to reverse cisplatin-resistance via enhancing NCOA4-mediated ferritinophagy in ovarian cancer. Int J Biol Macromol. 327:1472572025. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Z, Liu C, Fan C, Li R, Zhang S, Liu J, Li B, Zhang S, Guo L, Wang X, et al: E3 ubiquitin ligase DTX2 fosters ferroptosis resistance via suppressing NCOA4-mediated ferritinophagy in non-small cell lung cancer. Drug Resist Update. 77:1011542024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Q, Xu Z, Liu W, Cheng Z, Ding Y, Xie Y and Yan S: Gastrodin promotes ferroptosis in CRC cells by inhibiting SKP2 to reduce NCOA4 ubiquitination. Tissue Cell. 95:1027932025. View Article : Google Scholar : PubMed/NCBI | |
|
Shen C, Liu J, Liu H, Li G, Wang H, Tian H, Mao Y and Hua D: Timosaponin AIII induces lipid peroxidation and ferroptosis by enhancing Rab7-mediated lipophagy in colorectal cancer cells. Phytomedicine. 122:1550792024. View Article : Google Scholar : PubMed/NCBI | |
|
Gnanapradeepan K, Indeglia A, Stieg DC, Clarke N, Shao C, Dougherty JF, Murali N and Murphy ME: PLTP is a p53 target gene with roles in cancer growth suppression and ferroptosis. J Biol Chem. 298:1026372022. View Article : Google Scholar : PubMed/NCBI | |
|
Yang M, Chen P, Liu J, Zhu S, Kroemer G, Klionsky DJ, Lotze MT, Zeh HJ, Kang R and Tang D: Clockophagy is a novel selective autophagy process favoring ferroptosis. Sci Adv. 5:eaaw22382019. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang H, Wang X, Zhu Z, Song C, Li D, Yun Y, Hui L, Bao L, O Connor DP, Ma J and Xu G: DCAF7 recruits USP2 to facilitate hepatocellular carcinoma progression by suppressing clockophagy-induced ferroptosis. Cell Death Dis. 16:6542025. View Article : Google Scholar : PubMed/NCBI | |
|
Granata S, Votrico V, Spadaccino F, Catalano V, Netti GS, Ranieri E, Stallone G and Zaza G: Oxidative stress and ischemia/reperfusion injury in kidney transplantation: Focus on ferroptosis, mitophagy and new antioxidants. Antioxidants (Basel). 11:7692022. View Article : Google Scholar : PubMed/NCBI | |
|
Liu S, Chen JH, Li LC, Ye ZP, Liu JN, Chen YH, Hu BX, Tang JH, Feng GK, Li ZM, et al: Susceptibility of mitophagy-deficient tumors to ferroptosis induction by relieving the suppression of lipid peroxidation. Adv Sci (Weinh). 12:e24125932025. View Article : Google Scholar : PubMed/NCBI | |
|
Yu S, Li Z, Zhang Q, Wang R, Zhao Z, Ding W, Wang F, Sun C, Tang J, Wang X, et al: GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis. Ecotoxicol Environ Saf. 234:1134132022. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H and Yuan J: Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc Natl Acad Sci USA. 116:2996–3005. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Peng Y, Zhou M, Che Y, Zhao S, He C, Zhang W, Tian X, Zhang W, Liu Z, et al: P23 acts as a negative regulator of ferroptosis in NSCLC by blocking GPX4 degradation via chaperone-mediated autophagy. Mol Cancer. 24:2342025. View Article : Google Scholar : PubMed/NCBI | |
|
Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, Ji G, Shen Y, Wang L, Li L, et al: Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nat Cell Biol. 25:714–725. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Lei G, Zhuang L and Gan B: The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions. Cancer Cell. 42:513–534. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, et al: CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 569:270–274. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Liao P, Wang W, Wang W, Kryczek I, Li X, Bian Y, Sell A, Wei S, Grove S, Johnson JK, et al: CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 40:365–378.e6. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang Y, Li J, Wang T, Gu X, Li X, Liu Z, Yue W and Li M: VIPAS39 confers ferroptosis resistance in epithelial ovarian cancer through exporting ACSL4. Ebiomedicine. 114:1056462025. View Article : Google Scholar : PubMed/NCBI | |
|
Gao Y, Liu S, Huang Y, Wang H, Zhao Y, Cui X, Peng Y, Li F and Zhang Y: CAR T cells engineered to secrete IFNκ induce tumor ferroptosis via an IFNAR/STAT1/ACSL4 axis. Cancer Immunol Res. 12:1691–1702. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Liang Y and Zhao Y, Qi Z, Li X and Zhao Y: Ferroptosis: CD8+T cells' blade to destroy tumor cells or poison for self-destruction. Cell Death Discov. 11:1282025. View Article : Google Scholar : PubMed/NCBI | |
|
Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, et al: Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 54:1561–1577.e7. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Ma X, Xiao L, Liu L, Ye L, Su P, Bi E, Wang Q, Yang M, Qian J and Yi Q: CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability. Cell Metab. 33:1001–1012.e5. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Z, Hu B, Deng Y, Soeung M, Yao J, Bei L, Zhang Y, Gong P, Huang LA, Jiang Z, et al: Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity. Immunity. 58:1484–1501.e11. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Li S, Ouyang X, Sun H, Jin J, Chen Y, Li L, Wang Q, He Y, Wang J, Chen T, et al: DEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism. Cell Discov. 10:532024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang C, Wang X, Zhang D, Sun X, Wu Y, Wang J, Li Q and Jiang G: The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review). Oncol Rep. 50:1902023. View Article : Google Scholar : PubMed/NCBI | |
|
Li H, Yang P, Wang J, Zhang J, Ma Q, Jiang Y, Wu Y, Han T and Xiang D: HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk. J Hematol Oncol. 15:22022. View Article : Google Scholar : PubMed/NCBI | |
|
Luo X, Gong HB, Gao HY, Wu YP, Sun WY, Li ZQ, Wang G, Liu B, Liang L, Kurihara H, et al: Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2. Cell Death Differ. 28:1971–1989. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao L, Xian M, Zhang C, Guo Q and Yi Q: Lipid peroxidation of immune cells in cancer. Front Immunol. 14:13227462024. View Article : Google Scholar : PubMed/NCBI | |
|
Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, et al: Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 16:278–290. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Hao X, Zheng Z, Liu H, Zhang Y, Kang J, Kong X, Rong D, Sun G, Sun G, Liu L, et al: Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing. Redox Biol. 56:1024632022. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong H, Zhai Y, Meng Y, Wu Z, Qiu A, Cai Y, Wang G and Yang L: Acidosis activates breast cancer ferroptosis through ZFAND5/SLC3A2 signaling axis and elicits M1 macrophage polarization. Cancer Lett. 587:2167322024. View Article : Google Scholar : PubMed/NCBI | |
|
Huang WB, Lai HZ, Long J, Dai ZL, Ma Q, Xiao C and You FM: Biomechanics of the tumor extracellular matrix and regulatory T cells: Regulatory mechanisms and potential therapeutic targets. Cell Commun Signal. 23:3752025. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Q, Carlos AR, Braza F, Bergman ML, Kitoko JZ, Bastos-Amador P, Cuadrado E, Martins R, Oliveira BS, Martins VC, et al: Ferritin heavy chain supports stability and function of the regulatory T cell lineage. EMBO J. 43:1445–1483. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Sumida TS, Cheru NT and Hafler DA: The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases. Nat Rev Immunol. 24:503–517. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Yan J, Zeng Y, Guan Z, Li Z, Luo S, Niu J, Zhao J, Gong H, Huang T, Li Z, et al: Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis. Cell Rep. 43:1146362024. View Article : Google Scholar : PubMed/NCBI | |
|
Xu C, Sun S, Johnson T, Qi R, Zhang S, Zhang J and Yang K: The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Cell Rep. 35:1092352021. View Article : Google Scholar : PubMed/NCBI | |
|
Wculek SK, Cueto FJ, Mujal AM, Melero I, Krummel MF and Sancho D: Dendritic cells in cancer immunology and immunotherapy. Nat Rev Immunol. 20:7–24. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, et al: ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell. 161:1527–1538. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu Y, Gan M, Wang X, Liao T, Chen Q, Lei Y, Chen L, Wang J, Zhao Y, Niu L, et al: The global perspective on peroxisome proliferator-activated receptor γ (PPARγ) in ectopic fat deposition: A review. Int J Biol Macromol. 253((Pt 5)): 1270422023. View Article : Google Scholar : PubMed/NCBI | |
|
Han L, Bai L, Qu C, Dai E, Liu J, Kang R, Zhou D, Tang D and Zhao Y: PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity. Biochem Biophys Res Commun. 576:33–39. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao K, Zhang S, Peng Q, Du Y, Yao X, Ng II and Tang H: PD-L1 protects tumor-associated dendritic cells from ferroptosis during immunogenic chemotherapy. Cell Rep. 43:1148682024. View Article : Google Scholar : PubMed/NCBI | |
|
Li JY, Ren C, Wang LX, Yao RQ, Dong N, Wu Y, Tian YP and Yao YM: Sestrin2 protects dendrite cells against ferroptosis induced by sepsis. Cell Death Dis. 12:8342021. View Article : Google Scholar : PubMed/NCBI | |
|
Li M, Jin S, Ma H, Yang X and Zhang Z: Reciprocal regulation between ferroptosis and STING-type I interferon pathway suppresses head and neck squamous cell carcinoma growth through dendritic cell maturation. Oncogene. 44:1922–1935. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Su C, Wei X, Wei N, Qian Q and Xu Z: Prospects and applications of NK therapy in the treatment of gliomas (Review). Oncol Rep. 54:882025. View Article : Google Scholar : PubMed/NCBI | |
|
Poznanski SM, Singh K, Ritchie TM, Aguiar JA, Fan IY, Portillo AL, Rojas EA, Vahedi F, El-Sayes A, Xing S, et al: Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment. Cell Metab. 33:1205–1220.e5. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen T, Zhou S, Zhang Y, Meng H, Miao H, Feng M, Jiang Y, Wan Y, Zhang L and Cheng W: Overcoming ferroptosis-induced exhaustion of NK cells through inhibition of the ATF3-Mediated integrated stress response in ovarian cancer. Int J Biol Sci. 21:5531–5546. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Yao L, Hou J, Wu X, Lu Y, Jin Z, Yu Z, Yu B, Li J, Yang Z, Li C, et al: Cancer-associated fibroblasts impair the cytotoxic function of NK cells in gastric cancer by inducing ferroptosis via iron regulation. Redox Biol. 67:1029232023. View Article : Google Scholar : PubMed/NCBI | |
|
Pan B, Zhang X, Ye D, Yao Y, Zhang Z, Luo Y, Wu H, Wang X and Tang N: Intratumoral Brevibacillus parabrevis enhances antitumor immunity by inhibiting NK cell ferroptosis in hepatocellular carcinoma. Cell Death Dis. 16:4072025. View Article : Google Scholar : PubMed/NCBI | |
|
Dagher OK and Posey AD Jr: Forks in the road for CAR T and CAR NK cell cancer therapies. Nat Immunol. 24:1994–2007. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wu L, Liu F, Yin L, Wang F, Shi H, Zhao Q, Yang F, Chen D, Dong X, Gu Y and Xing N: The establishment of polypeptide PSMA-targeted chimeric antigen receptor-engineered natural killer cells for castration-resistant prostate cancer and the induction of ferroptosis-related cell death. Cancer Commun (Lond). 42:768–783. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Tao B, Du R, Zhang X, Jia B, Gao Y, Zhao Y and Liu Y: Engineering CAR-NK cell derived exosome disguised nano-bombs for enhanced HER2 positive breast cancer brain metastasis therapy. J Control Release. 363:692–706. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang F, Ma Y, Li D, Wei J, Chen K, Zhang E, Liu G, Chu X, Liu X, Liu W, et al: Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution. J Hematol Oncol. 17:802024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang K, Guo L, Li X, Hu Y and Luo N: Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis. J Transl Med. 23:2472025. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang F, Jia K, Chen Y, Ji C, Chong X, Li Z, Zhao F, Bai Y, Ge S, Gao J, et al: ANO1-Mediated inhibition of cancer ferroptosis confers immunotherapeutic resistance through recruiting cancer-associated fibroblasts. Adv Sci (Weinh). 10:e23008812023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao J, Shen J, Mao L, Yang T, Liu J and Hongbin S: Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer. Oncogene. 43:2104–2114. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Du J, Meng X, Yang M, Chen G, Li J, Zhu Z, Wu X, Hu W, Tian M, Li T, et al: NGR-Modified CAF-Derived exos targeting tumor vasculature to induce ferroptosis and overcome chemoresistance in osteosarcoma. Adv Sci (Weinh). 12:e24109182025. View Article : Google Scholar : PubMed/NCBI | |
|
Rottenberg S, Disler C and Perego P: The rediscovery of platinum-based cancer therapy. Nat Rev Cancer. 21:37–50. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Koeberle SC, Kipp AP, Stuppner H and Koeberle A: Ferroptosis-modulating small molecules for targeting drug-resistant cancer: Challenges and opportunities in manipulating redox signaling. Med Res Rev. 43:614–682. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Yan C, Chang C, Meng F, Shen W, Wang S and Zhang Y: FOXA2 suppression by TRIM36 exerts anti-tumor role in colorectal cancer via inducing NRF2/GPX4-Regulated Ferroptosis. Adv Sci (Weinh). 10:e23045212023. View Article : Google Scholar : PubMed/NCBI | |
|
Xing P, Chen J, Hao H, Qiao X, Yang X, Weng K, Chen J, Song L, Liu T, Hou Y, et al: MTCH2 deficiency promotes E2F4/TFRC-Mediated ferroptosis and sensitizes colorectal cancer liver metastasis to sorafenib. Adv Sci (Weinh). 12:e000192025. View Article : Google Scholar : PubMed/NCBI | |
|
Song M, Huang S, Wu X, Zhao Z, Liu X, Wu C, Wang M, Gao J, Ke Z, Ma X and He W: UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SLC7A11 signaling. Redox Biol. 76:1033492024. View Article : Google Scholar : PubMed/NCBI | |
|
Xin Z, Hu C, Zhang C, Liu M, Li J, Sun X, Hu Y, Liu X and Wang K: LncRNA-HMG incites colorectal cancer cells to chemoresistance via repressing p53-mediated ferroptosis. Redox Biol. 77:1033622024. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu L, Li W, Zhang L, Zhang X, Zhao H, Miyagishi M, Wu S and Kasim V: p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization. Acta Pharm Sin B. 15:2039–2058. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Huo Z, Liu G and Li J: Recent research progress and clinical status of immunotherapy for colorectal cancer. J Adv Res. 82:729–750. 2026. View Article : Google Scholar : PubMed/NCBI | |
|
Lu Y, Xie X and Luo L: Ferroptosis crosstalk in anti-tumor immunotherapy: Molecular mechanisms, tumor microenvironment, application prospects. Apoptosis. 29:1914–1943. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Haoyue W, Kexiang S, Shan TW, Jiamin G, Luyun Y, Junkai W and Wanli D: Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors. Phytomedicine. 136:1562242025. View Article : Google Scholar : PubMed/NCBI | |
|
Lv Y, Tang W, Xu Y, Chang W, Zhang Z, Lin Q, Ji M, Feng Q, He G and Xu J: Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis. Int J Biol Sci. 19:1284–1298. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen P, Li X, Zhang R, Liu S, Xiang Y, Zhang M, Chen X, Pan T, Yan L, Feng J, et al: Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation. Theranostics. 10:5107–5119. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng H, Liu J, Cheng Q, Zhang Q, Zhang Y, Jiang L, Huang Y, Li W, Zhao Y, Chen G, et al: Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance. Nat Cancer. 5:572–589. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Gu Y, Wang Z and Wang Y: Bispecific antibody drug conjugates: Making 1+1>2. Acta Pharm Sin B. 14:1965–1986. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Du J, Cui X, Ling Y and Tang C: Development of a bispecific CDH17-GUCY2C ADC bearing the ferroptosis inducer RSL3 for the treatment of colorectal cancer. Cell Death Discov. 11:3472025. View Article : Google Scholar : PubMed/NCBI | |
|
Ouladan S and Orouji E: Chimeric antigen receptor-T cells in colorectal cancer: Pioneering new avenues in solid tumor immunotherapy. J Clin Oncol. 43:994–1005. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Li D, Zhang W, Wang R, Xie S, Wang Y, Guo W, Huang Z, Lu C, Shan L, Liu H, et al: ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2. Biomark Res. 13:172025. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, Miska J, Wu JD, Wainwright DA, Fang D, et al: CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4. J Clin Invest. 134:e1700712024. View Article : Google Scholar : PubMed/NCBI | |
|
Wong CC and Yu J: Gut microbiota in colorectal cancer development and therapy. Nat Rev Clin Oncol. 20:429–452. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Y, Zhang Y, Dai M, Qiu C, Sun Q, Fan T, Guo Y, Zhao L and Jiang Y: γ-Linolenic acid derived from Lactobacillus plantarum MM89 induces ferroptosis in colorectal cancer. Food Funct. 16:1760–1771. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Li B, Wei Z, Wang Z, Xu F, Yang J, Lin B, Chen Y, Wenren H, Wu L, Guo X, et al: Fusobacterium nucleatum induces oxaliplatin resistance by inhibiting ferroptosis through E-cadherin/β-catenin/GPX4 axis in colorectal cancer. Free Radical Bio Med. 220:125–138. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Liu R, Wang J, Liu Y, Gao Y and Yang R: Regulation of gut microbiota on immune cell ferroptosis: A novel insight for immunotherapy against tumor. Cancer Lett. 598:2171152024. View Article : Google Scholar : PubMed/NCBI | |
|
Cui W, Guo M, Liu D, Xiao P, Yang C, Huang H, Liang C, Yang Y, Fu X, Zhang Y, et al: Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. Nat Cell Biol. 26:124–137. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou J, Lu P, He H, Zhang R, Yang D, Liu Q, Liu Q, Liu M and Zhang G: The metabolites of gut microbiota: Their role in ferroptosis in inflammatory bowel disease. Eur J Med Res. 30:2482025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou H, Zhuang Y, Liang Y, Chen H, Qiu W, Xu H and Zhou H: Curcumin exerts anti-tumor activity in colorectal cancer via gut microbiota-mediated CD8+ T Cell tumor infiltration and ferroptosis. Food Funct. 16:3671–3693. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
O'Keefe SJ: Diet, microorganisms and their metabolites, and colon cancer. Nat Rev Gastroenterol Hepatol. 13:691–706. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Lin Y, Zhang Y, Huang T, Chen J, Li G, Zhang B, Xu L, Wang K, He H, Chen H, et al: Arginine deprivation induces quiescence and confers vulnerability to ferroptosis in colorectal cancer. Cancer Res. 85:1663–1679. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
He Y, Ling Y, Zhang Z, Mertens RT, Cao Q, Xu X, Guo K, Shi Q, Zhang X, Huo L, et al: Butyrate reverses ferroptosis resistance in colorectal cancer by inducing c-Fos-dependent xCT suppression. Redox Biol. 65:1028222023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou X, Wang G, Wu Y, Wu M, Zhai X, Tian C, Prochownik EV, Jiang C and Li Y: SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer. Cell Rep. 44:1161392025. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Q, Zhao Y, Zhou H and Chen C: Ferroptosis: Challenges and opportunities for nanomaterials in cancer therapy. Regen Biomater. 10:rbad0042023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Ji Y, Hu N, Yu Q, Zhang X, Li J, Wu F, Xu H, Tang Q and Li X: Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment. Asian J Pharm Sci. 17:751–766. 2022.PubMed/NCBI | |
|
Wang H, Qiao C, Guan Q, Wei M and Li Z: Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: Novel insights and perspectives. Asian J Pharm Sci. 18:1008292023.PubMed/NCBI | |
|
Luo J, Xu L, Feng J, Xu K, Tian P, Bai X, Xu S, Wen L, Lu C and Song J: Tumor microenvironment-activated and ROS-Augmented nanoplatform amplified PDT against colorectal cancer through impairing GPX4 to induce ferroptosis. ACS Appl Mater Interfaces. 17:41586–41596. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
He M, Du C, Xia J, Zhang ZG and Dong CM: Multivalent polypeptide and tannic acid cooperatively iron-coordinated nanohybrids for synergistic cancer photothermal ferroptosis therapy. Biomacromolecules. 23:2655–2666. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Deng K, Tian H, Zhang T, Gao Y, Nice EC, Huang C, Xie N, Ye G and Zhou Y: Chemo-photothermal nanoplatform with diselenide as the key for ferroptosis in colorectal cancer. J Control Release. 366:684–693. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Yang H, Yao X, Liu Y, Shen X, Li M and Luo Z: Ferroptosis nanomedicine: Clinical challenges and opportunities for modulating tumor metabolic and immunological landscape. ACS Nano. 17:15328–15353. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Duan Y, Li Y, Gu Y, Zhou L, Xiao Z, Yu X, Cai Y, Cheng E, Liu Q, et al: Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer. Exploration (Beijing). 5:202301172024. View Article : Google Scholar : PubMed/NCBI | |
|
McCoubrey LE, Favaron A, Awad A, Orlu M, Gaisford S and Basit AW: Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics. J Control Release. 353:1107–1126. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Ye C, Mi M, Shi S, Qi L, Weng S, Wang L, Lu Y, Chen C, Tan Y, Yang M, et al: ROS-Responsive hydrogel for localized delivery of nampt and Stat3 inhibitors exhibits synergistic antitumor effects in colorectal cancer through ferroptosis induction and immune microenvironment remodeling. Adv Sci (Weinh). 12:e065992025. View Article : Google Scholar : PubMed/NCBI | |
|
Huang M, Wu Y, Wei X, Cheng L, Fu L, Yan H, Wei W, Li B, Ru H, Mo X, et al: Trifluridine/tipiracil induces ferroptosis by targeting p53 via the p53-SLC7A11 axis in colorectal cancer 3D organoids. Cell Death Dis. 16:2552025. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Qi D, Ge G, Cao N, Liu X, Zhu N, Li F, Huang X, Yu K, Zheng J, et al: WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer. Mol Med. 31:932025. View Article : Google Scholar : PubMed/NCBI | |
|
Qian LH, Wen KL, Guo Y, Liao YN, Li MY, Li ZQ, Li SX and Nie HZ: Nutrient deficiency-induced downregulation of SNX1 inhibits ferroptosis through PPARs-ACSL1/4 axis in colorectal cancer. Apoptosis. 30:1391–1409. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Chen C, Yang Y, Guo Y, He J, Chen Z, Qiu S, Zhang Y, Ding H, Pan J and Pan Y: CYP1B1 inhibits ferroptosis and induces anti-PD-1 resistance by degrading ACSL4 in colorectal cancer. Cell Death Dis. 14:2712023. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S, Ma J, Tang J, Yang Y, Zhou S and Feng P: Research progress of macrophage ferroptosis in inflammatory bowel disease and inflammation-cancer transformation. Front Immunol. 16:16582802025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Zhang Y, Yao S, Chen L, Dong Q, Luo R, Zheng K, Liu J, Liu Y, Chen Y, et al: Inflammatory bowel disease induces colorectal cancer: Risk factors, triggering mechanisms, and treatment with phyto-derivatives. Phytother Res. 39:3386–3418. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Iacucci M, Nardone OM, Ditonno I, Capobianco I, Pugliano CL, Maeda Y, Majumder S, Zammarchi I, Santacroce G and Ghosh S: Advancing inflammatory bowel disease-driven colorectal cancer management: Molecular insights and endoscopic breakthroughs towards precision medicine. Clin Gastroenterol Hepatol. 23:2361–2373. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Burgos-Molina AM, Téllez Santana T, Redondo M and Bravo Romero MJ: The Crucial role of inflammation and the immune system in colorectal cancer carcinogenesis: A comprehensive perspective. Int J Mol Sci. 25:61882024. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Zhang JT, Sun M, Song J, Sun HM, Wang MY, Wang CM and Liu W: Targeting ferroptosis in the treatment of ulcerative colitis by traditional Chinese medicine: A novel therapeutic strategies. Phytomedicine. 139:1565392025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang K, Guo J, Yan W and Xu L: Macrophage polarization in inflammatory bowel disease. Cell Commun Signal. 21:3672023. View Article : Google Scholar : PubMed/NCBI | |
|
Liang J, Wang N, Yao Y, Wang Y, An X, Wang H, Liu H, Jiang Y, Li H, Cheng X, et al: NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis. J Clin Invest. 135:e1739942024. View Article : Google Scholar : PubMed/NCBI | |
|
Na YR, Stakenborg M, Seok SH and Matteoli G: Macrophages in intestinal inflammation and resolution: A potential therapeutic target in IBD. Nat Rev Gastroenterol Hepatol. 16:531–543. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Meng EX, Verne GN and Zhou Q: Macrophages and gut barrier function: Guardians of gastrointestinal health in post-inflammatory and post-infection responses. Int J Mol Sci. 25:94222024. View Article : Google Scholar : PubMed/NCBI | |
|
Tang B, Zhu J, Fang S, Wang Y, Vinothkumar R, Li M, Weng Q, Zheng L, Yang Y, Qiu R, et al: Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis. Free Radic Biol Med. 172:312–329. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Kuang Z, Su Q, Liang W, Shen K and Xie J: PRSS22 inhibits HMOX1-mediated ferroptosis and induces osteopontin cleavage to promote M2 macrophage polarization and colitis-associated carcinogenesis. Oncogene. 45:1275–1286. 2026. View Article : Google Scholar : PubMed/NCBI | |
|
Wang S, Zhu L, Wang Y, Han Y, Wang Q, Yang W, Zhao L, Zhang Y, Pei D, Huang W, et al: ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA. Cell Death Dis. 16:5492025. View Article : Google Scholar : PubMed/NCBI | |
|
Xiang Y, Zheng J, Zhao X, Zhou L, Yan Q, Ma Y, Zhou Y, Jiang P, Fang Y, Li W, et al: Sodium butyrate enhances sorafenib-induced ferroptosis and immunogenic cell death by modulating IRF2-Oasl2-cGAS pathway in colorectal cancer. Mater Today Bio. 35:1024982025. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Wang J and Chen L: TIMP1 represses sorafenib-triggered ferroptosis in colorectal cancer cells by activating the PI3K/Akt signaling pathway. Immunopharmacol Immunotoxicol. 45:419–425. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Wang R, Xing R, Su Q, Yin H, Di Wu, Lv C and Yan Z: Knockdown of SFRS9 inhibits progression of colorectal cancer through triggering ferroptosis mediated by GPX4 Reduction. Front Oncol. 11:6835892021. View Article : Google Scholar : PubMed/NCBI | |
|
Jacobs SA, Lee JJ, George TJ, Wade JL III, Stella PJ, Wang D, Sama AR, Piette F, Pogue-Geile KL, Kim RS, et al: Neratinib-plus-cetuximab in quadruple-WT (KRAS, NRAS, BRAF, PIK3CA) metastatic colorectal cancer resistant to cetuximab or panitumumab: NSABP FC-7, A phase Ib study. Clin Cancer Res. 27:1612–1622. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Ren M, Jian Z, Li C, Cao J, Ma X, He L, Zhang Y, Chen Y and Xu Y: Design, synthesis, and in vitro/in vivo biological evaluation of Artesunate-Ebselen derivatives: GPX4-targeted ferroptosis induction and synergistic antitumor immune activation in colorectal cancer. Bioorg Chem. 174:1097552026. View Article : Google Scholar : PubMed/NCBI | |
|
Chen HC, Chen CY, Wang PY, Su PY, Tsai SP, Hsu CP, Liu HS, Huang CF, Cheng WH, Lee MF and Su CL: Using integrated bioinformatics analysis to identify saponin formosanin C as a ferroptosis inducer in colorectal cancer with p53 and oncogenic KRAS. Antioxidants (Basel). 14:10272025. View Article : Google Scholar : PubMed/NCBI | |
|
Niu X, Wang M, Wang M, Liu X, Zhang Y, Zheng P, Zhang S, Liu T, Cao Z and Zhang C: Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis. Int Immunopharmacol. 158:1148272025. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng L, Zhao W, Han T, Qing F, He Z, Zhao Q, Luo A, Hu P, Ding X and Zhang Z: Ropivacaine prompts ferroptosis to enhance the cisplatin-sensitivity of human colorectal cancer through SIRT1/Nrf2 signaling pathway. Chem Biol Interact. 400:1111632024. View Article : Google Scholar : PubMed/NCBI | |
|
Huang JY, Hsu TW, Chen YR and Kao SH: Rosmarinic acid potentiates cytotoxicity of cisplatin against colorectal cancer cells by enhancing apoptotic and ferroptosis. Life (Basel). 14:10172024.PubMed/NCBI | |
|
Zeng X, Sun L, Ling X, Jiang Y, Shen J, Liang L and Zhang X: Comprehensive analysis identifies novel targets of gemcitabine to improve chemotherapy treatment strategies for colorectal cancer. Front Endocrinol (Lausanne). 14:11705262023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Song X, Zhao L, Wang C, Chen S, Wang Y, Zhang L, Xu F, Zhang H, Wang Q and Luo C: Singlet oxygen-precharged injectable hydrogel triggers ferroptosis and lactate metabolism reprogramming for enhanced colorectal cancer immunotherapy. J Nanobiotechnol. 24:1862026. View Article : Google Scholar | |
|
Xie P, Yang ST, Huang Y, Zeng C, Xin Q, Zeng G, Yang S, Xia P, Tang X and Tang K: Carbon nanoparticles-Fe(II) complex for efficient tumor inhibition with low toxicity by amplifying oxidative stress. ACS Appl Mater Interfaces. 12:29094–29102. 2020.PubMed/NCBI | |
|
Rochette L, Dogon G, Rigal E, Zeller M, Cottin Y and Vergely C: Lipid peroxidation and iron metabolism: Two corner stones in the homeostasis control of ferroptosis. Int J Mol Sci. 24:4492022. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X, Comish PB, Tang D and Kang R: Characteristics and biomarkers of ferroptosis. Front Cell Dev Biol. 9:6371622021. View Article : Google Scholar : PubMed/NCBI | |
|
Matsuoka Y, Katsumata Y, Chu PS, Morikawa R, Nakamoto N, Iguchi K, Takahashi K, Kou T, Ito R, Taura K, et al: Monitoring ferroptosis in vivo: Iron-driven volatile oxidized lipids as breath biomarkers. Redox Biol. 86:1038582025. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao YP, Liu JL, Wang S and Li X: Role of non-coding RNA-regulated ferroptosis in colorectal cancer. Cell Death Discov. 11:3152025. View Article : Google Scholar : PubMed/NCBI | |
|
Ge X, Xu J, He J, Wang J and Qian Y: Identification and functional characterization of prognosis-related ferroptosis-associated lncRNAs in colorectal cancer. Front Immunol. 16:15612102025. View Article : Google Scholar : PubMed/NCBI | |
|
Chu X, Li X, Zhang Y, Dang G, Miao Y, Xu W, Wang J, Zhang Z and Cheng S: Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms. Nat Cancer. 5:1409–1426. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Wu N, Li J, Liang J, Zhou D, Cao Q, Li X and Jiang N: The interplay between autophagy and ferroptosis presents a novel conceptual therapeutic framework for neuroendocrine prostate cancer. Pharmacol Res. 203:1071622024. View Article : Google Scholar : PubMed/NCBI | |
|
Hu Q, Wei W, Wu D, Huang F, Li M, Li W, Yin J, Peng Y, Lu Y, Zhao Q and Liu L: Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis. Front Cell Dev Biol. 10:8103272022. View Article : Google Scholar : PubMed/NCBI | |
|
Ubellacker JM and Dixon SJ: Prospects for ferroptosis therapies in cancer. Nat Cancer. 6:1326–1336. 2025. View Article : Google Scholar : PubMed/NCBI | |
|
Yan YY, Zhou HM, Shang XG, Xu P, Tang XQ, Zheng XY, Yu LH, Li CT, Xie T and Lou JS: Dynamic regulators of ferroptosis: Post-translational modifications in ferroptotic cell death. Pharmacol Res. 217:1078152025. View Article : Google Scholar : PubMed/NCBI | |
|
Feng S, Rao Z, Zhang J, She X, Chen Y, Wan K, Li H, Zhao C, Feng Y, Wang G, et al: Inhibition of CARM1-Mediated methylation of ACSL4 promotes ferroptosis in colorectal cancer. Adv Sci (Weinh). 10:e23034842023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang S, Xiao Y, Xie Z, Liu S, Li J, He P, Lai Y, Yin Y, Lin H, Pan H and Fang C: Jianpi Huayu Jiedu Decoction prevents the progression of H. pylori and MNU-induced gastric precancerous lesions by inhibiting ferroptosis and remodeling linoleic acid metabolism. J Ethnopharmacol. 352:1202172025. View Article : Google Scholar : PubMed/NCBI | |
|
Luo G, Jiang X, Hu C, Li L, Yan L, Xiao G, Duo Y and Zhang X: Artificial intelligence-powered nanomedicine. Chem Soc Rev. 55:2070–2119. 2026. View Article : Google Scholar : PubMed/NCBI | |
|
Hou J, Karin M and Sun B: Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age? Nat Rev Clin Oncol. 18:261–279. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Escuder-Rodríguez JJ, Liang D, Jiang X and Sinicrope FA: Ferroptosis: Biology and role in gastrointestinal disease. Gastroenterology. 167:231–249. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu J, Zhang J, Lou Y, Zheng Y, Zheng X, Cen W, Ye L and Zhang Q: Developing a machine learning-based prognosis and immunotherapeutic response signature in colorectal cancer: insights from ferroptosis, fatty acid dynamics, and the tumor microenvironment. Front Immunol. 15:14164432024. View Article : Google Scholar : PubMed/NCBI | |
|
Wei X, Jiang Y, Chenwu F, Li Z, Wan J, Li Z, Zhang L, Wang J and Song M: Synergistic ferroptosis-immunotherapy nanoplatforms: Multidimensional engineering for tumor microenvironment remodeling and therapeutic optimization. Nanomicro Lett. 18:562025.PubMed/NCBI |