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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August-2026 Volume 56 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article Open Access

Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer

  • Authors:
    • Kunkun Han
    • Qianyun Zhang
    • Shengnan Gao
    • Jigang Zhang
    • Xiao Mei
    • Fei Li
    • Xin Xu
    • Shu Li
    • Guodong Chen

  • View Affiliations / Copyright

    Affiliations: School of Basic Medical Sciences, Wannan Medical College, Wuhu, Anhui 241002, P.R. China, Department of Emergency Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Center for Self‑Propelled Nanotechnologies, College of Biotechnology, Suzhou Industrial Park Institute of Services Outsourcing, Suzhou, Jiangsu 215125, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 140
    |
    Published online on: May 29, 2026
       https://doi.org/10.3892/or.2026.9145
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Abstract

Pancreatic cancer mortality remains high due to late diagnosis and therapeutic resistance. The present study investigated acylglycerol kinase (AGK), which has been implicated in other tumors, in pancreatic cancer. Quantitative PCR, western blotting and immunohistochemistry analyses showed that AGK was markedly upregulated in pancreatic cancer tissues and cell lines and its expression associated with poor prognosis. Furthermore, functional studies using AGK knockdown and overexpression models demonstrated that AGK promoted cancer cell proliferation by upregulating proliferation‑associated genes, such as MYC, MKI67 and CCNB1. Mechanistically, AGK activates NF‑κB signaling pathway by facilitating p65 nuclear translocation and enhancing its phosphorylation. Additionally, CCK‑8 and colony formation assays further indicated that elevated AGK levels reduced sensitivity to therapeutic drugs and irradiation in pancreatic cancer cells. These findings revealed the critical role of AGK in pancreatic cancer progression and treatment resistance, identifying it as a potential novel therapeutic target and diagnostic marker.

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Copy and paste a formatted citation
Spandidos Publications style
Han K, Zhang Q, Gao S, Zhang J, Mei X, Li F, Xu X, Li S and Chen G: Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer. Oncol Rep 56: 140, 2026.
APA
Han, K., Zhang, Q., Gao, S., Zhang, J., Mei, X., Li, F. ... Chen, G. (2026). Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer. Oncology Reports, 56, 140. https://doi.org/10.3892/or.2026.9145
MLA
Han, K., Zhang, Q., Gao, S., Zhang, J., Mei, X., Li, F., Xu, X., Li, S., Chen, G."Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer". Oncology Reports 56.2 (2026): 140.
Chicago
Han, K., Zhang, Q., Gao, S., Zhang, J., Mei, X., Li, F., Xu, X., Li, S., Chen, G."Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer". Oncology Reports 56, no. 2 (2026): 140. https://doi.org/10.3892/or.2026.9145
Copy and paste a formatted citation
x
Spandidos Publications style
Han K, Zhang Q, Gao S, Zhang J, Mei X, Li F, Xu X, Li S and Chen G: Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer. Oncol Rep 56: 140, 2026.
APA
Han, K., Zhang, Q., Gao, S., Zhang, J., Mei, X., Li, F. ... Chen, G. (2026). Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer. Oncology Reports, 56, 140. https://doi.org/10.3892/or.2026.9145
MLA
Han, K., Zhang, Q., Gao, S., Zhang, J., Mei, X., Li, F., Xu, X., Li, S., Chen, G."Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer". Oncology Reports 56.2 (2026): 140.
Chicago
Han, K., Zhang, Q., Gao, S., Zhang, J., Mei, X., Li, F., Xu, X., Li, S., Chen, G."Acylglycerol kinase contributes to cell proliferation by activating NF‑κB signaling pathway in pancreatic cancer". Oncology Reports 56, no. 2 (2026): 140. https://doi.org/10.3892/or.2026.9145
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