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Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.

  • Authors:
    • K Tanimoto
    • S M Akbar
    • Y Yamauchi
    • K Michitaka
    • N Horiike
    • M Onji

  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/or.5.4.805
  • Pages: 805-814
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Abstract

Metallothionein (MT), an oncofocal gene product was strongly expressed in 35%-95% of hepatocytes in hepatocellular carcinoma (HCC) and MT-positive hepatocytes were localized mainly in the non-cancerous cirrhotic nodules but not in malignant hepatocytes. On the other hand, <10% hepatocytes showed weak staining for MT in chronic hepatitis and cirrhosis of liver. Strong expressions of MT in non-cancerous cirrhotic nodule in HCC and low expressions in liver cirrhosis without HCC indicate a relationship between malignant transformation of hepatocytes and the expression of MT.

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Jul-Aug 1998
Volume 5 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Tanimoto K, Akbar S, Yamauchi Y, Michitaka K, Horiike N and Onji M: Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.. Oncol Rep 5: 805-814, 1998
APA
Tanimoto, K., Akbar, S., Yamauchi, Y., Michitaka, K., Horiike, N., & Onji, M. (1998). Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.. Oncology Reports, 5, 805-814. https://doi.org/10.3892/or.5.4.805
MLA
Tanimoto, K., Akbar, S., Yamauchi, Y., Michitaka, K., Horiike, N., Onji, M."Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.". Oncology Reports 5.4 (1998): 805-814.
Chicago
Tanimoto, K., Akbar, S., Yamauchi, Y., Michitaka, K., Horiike, N., Onji, M."Immunohistochemical localization of metallothionein in hepatocellular carcinoma: preferential expression in non-cancerous cirrhotic nodules.". Oncology Reports 5, no. 4 (1998): 805-814. https://doi.org/10.3892/or.5.4.805