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Hepatocyte growth factor and Met/HGF receptors in patients with gastric adenocarcinoma.

  • Authors:
    • C W Wu
    • A F Li
    • C W Chi
    • W W Chung
    • T Y Liu
    • W Y Lui
    • F K P'eng

  • View Affiliations

  • Published online on: July 1, 1998     https://doi.org/10.3892/or.5.4.817
  • Pages: 817-839
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Overexpression and amplification of Met/HGF receptor has been detected in gastric cancer tissues and cell lines. In this study hepatocyte growth factor (HGF) and Met/HGF receptors were localized in 32 gastric cancer and adjacent normal gastric tissues by the avidin-biotin-peroxidase complex technique. HGF (87.5%) and Met/HGF receptors (68.8%) were demonstrated in gastric cancer tissues. A high positive rate of HGF (87.0%) and Met/ HGF receptors (82.6%) presented in intestinal type gastric cancer. HGF immunoreactivity in gastric cancer tissues was a significant and powerful prognostic indicator (relative risk 15.9; p=0.01). These data suggest that HGF and Met/HGF receptors are involved in the morphogenesis of intestinal type gastric cancer. HGF may have other mechanism that favor gastric cancer spread and independently affect survival.

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Jul-Aug 1998
Volume 5 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Wu C, Li A, Chi C, Chung W, Liu T, Lui W and P'eng F: Hepatocyte growth factor and Met/HGF receptors in patients with gastric adenocarcinoma.. Oncol Rep 5: 817-839, 1998
APA
Wu, C., Li, A., Chi, C., Chung, W., Liu, T., Lui, W., & P'eng, F. (1998). Hepatocyte growth factor and Met/HGF receptors in patients with gastric adenocarcinoma.. Oncology Reports, 5, 817-839. https://doi.org/10.3892/or.5.4.817
MLA
Wu, C., Li, A., Chi, C., Chung, W., Liu, T., Lui, W., P'eng, F."Hepatocyte growth factor and Met/HGF receptors in patients with gastric adenocarcinoma.". Oncology Reports 5.4 (1998): 817-839.
Chicago
Wu, C., Li, A., Chi, C., Chung, W., Liu, T., Lui, W., P'eng, F."Hepatocyte growth factor and Met/HGF receptors in patients with gastric adenocarcinoma.". Oncology Reports 5, no. 4 (1998): 817-839. https://doi.org/10.3892/or.5.4.817