Thallium-201-chloride and technetium-99m-MIBI SPECT of primary and metastatic lung carcinoma.

  • Authors:
    • N Kashitani
    • S Makihara
    • T Maeda
    • R Eda
    • H Takeyama
    • Y Hiraki
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/or.6.1.127
  • Pages: 127-160
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Abstract

We compared technetium-99m-MIBI (Tc-99m MIBI) with thallium-201-chloride (Tl-201) SPECT imaging in patients with lung carcinoma. In addition, we compared the imaging characteristics of Tl-201 and Tc-99m MIBI after radiation therapy. Thirty-seven patients with primary lung carcinoma were evaluated with SPECT imaging for metastasis to the mediastinal lymph nodes and brain. Patients were imaged with Tl-201 chloride images 10 and 180 min after injection. Patients were also imaged 10 min after injection of Tc-99m MIBI. The sensitivity of Tl-201 SPECT for the primary lesion and brain metastasis was 97.1% and 70.0% respectively at 10 min and 97.1% and 60.0% at 180 min. The sensitivity of Tc-99m MIBI SPECT was 97.1% (for the identification of the primary lesion) and 50.0% (for the detection of brain metastasis) at 10 min. The uptake ratios (count in tumor/count in normal lung or brain) at 10 min on the Tl-201 SPECT and on the Tc-99m MIBI SPECT were not significantly different for the primary tumor or for brain metastasis. The uptake ratios were better for Tc-99m MIBI than for Tl-201 [2.82 vs. 1.99 (p<0.05)] for mediastinal lymph nodes. Decreasing uptake ratios and retention index with both agents after radiation therapy are concordant to the follow-up clinical course. Tc-99m MIBI SPECT is more sensitive in the detection of metastasis to mediastinal lymph nodes than Tl-201 SPECT.

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Jan-Feb 1999
Volume 6 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kashitani N, Makihara S, Maeda T, Eda R, Takeyama H and Hiraki Y: Thallium-201-chloride and technetium-99m-MIBI SPECT of primary and metastatic lung carcinoma.. Oncol Rep 6: 127-160, 1999
APA
Kashitani, N., Makihara, S., Maeda, T., Eda, R., Takeyama, H., & Hiraki, Y. (1999). Thallium-201-chloride and technetium-99m-MIBI SPECT of primary and metastatic lung carcinoma.. Oncology Reports, 6, 127-160. https://doi.org/10.3892/or.6.1.127
MLA
Kashitani, N., Makihara, S., Maeda, T., Eda, R., Takeyama, H., Hiraki, Y."Thallium-201-chloride and technetium-99m-MIBI SPECT of primary and metastatic lung carcinoma.". Oncology Reports 6.1 (1999): 127-160.
Chicago
Kashitani, N., Makihara, S., Maeda, T., Eda, R., Takeyama, H., Hiraki, Y."Thallium-201-chloride and technetium-99m-MIBI SPECT of primary and metastatic lung carcinoma.". Oncology Reports 6, no. 1 (1999): 127-160. https://doi.org/10.3892/or.6.1.127