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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
Jan-Feb 1999 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan-Feb 1999 Volume 6 Issue 1

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Article

Clinical significance of p53 in non-small-cell lung cancer.

  • Authors:
    • T Komiya
    • T Hirashima
    • I Kawase

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Habikino City, Osaka, Japan.
  • Pages: 19-47
    |
    Published online on: January 1, 1999
       https://doi.org/10.3892/or.6.1.19
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Abstract

p53 abnormalities appear to play critical roles in human carcinogenesis. Many studies have indicated that p53 alteration is responsible for the differences in clinical characteristics of non-small cell lung cancer (NSCLC). The purpose of this review is to evaluate and summarize the significance of p53 alteration in the diagnosis and therapy of NSCLC. After assessing the principles of each approach to detecting p53 alteration, we reviewed the literature describing the impact of p53 alteration on clinical modalities such as diagnosis, prediction of prognosis, and response to treatment. We also reviewed p53 gene replacement therapy for NSCLC. Although p53 appears to be the most important gene in the development of NSCLC, it is not known whether p53 abnormalities are useful markers for clinicians. A multicenter, prospective study of p53 immunohistochemistry should therefore be performed. Replacement of the p53 gene has been shown to be effective in a clinical trial for patients with NSCLC. In addition to simple gene replacement, combination treatments of gene transfer and chemotherapy are now being tested in clinical trials.

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Copy and paste a formatted citation
Spandidos Publications style
Komiya T, Hirashima T and Kawase I: Clinical significance of p53 in non-small-cell lung cancer.. Oncol Rep 6: 19-47, 1999.
APA
Komiya, T., Hirashima, T., & Kawase, I. (1999). Clinical significance of p53 in non-small-cell lung cancer.. Oncology Reports, 6, 19-47. https://doi.org/10.3892/or.6.1.19
MLA
Komiya, T., Hirashima, T., Kawase, I."Clinical significance of p53 in non-small-cell lung cancer.". Oncology Reports 6.1 (1999): 19-47.
Chicago
Komiya, T., Hirashima, T., Kawase, I."Clinical significance of p53 in non-small-cell lung cancer.". Oncology Reports 6, no. 1 (1999): 19-47. https://doi.org/10.3892/or.6.1.19
Copy and paste a formatted citation
x
Spandidos Publications style
Komiya T, Hirashima T and Kawase I: Clinical significance of p53 in non-small-cell lung cancer.. Oncol Rep 6: 19-47, 1999.
APA
Komiya, T., Hirashima, T., & Kawase, I. (1999). Clinical significance of p53 in non-small-cell lung cancer.. Oncology Reports, 6, 19-47. https://doi.org/10.3892/or.6.1.19
MLA
Komiya, T., Hirashima, T., Kawase, I."Clinical significance of p53 in non-small-cell lung cancer.". Oncology Reports 6.1 (1999): 19-47.
Chicago
Komiya, T., Hirashima, T., Kawase, I."Clinical significance of p53 in non-small-cell lung cancer.". Oncology Reports 6, no. 1 (1999): 19-47. https://doi.org/10.3892/or.6.1.19
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