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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jan-Feb 1999 Volume 6 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jan-Feb 1999 Volume 6 Issue 1

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Article

Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.

  • Authors:
    • S Peller
    • R Halperin
    • D Schneider
    • Y Kopilova
    • V Rotter

  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Assaf-Harofeh Medical Center, Zerifin 70300, Israel.
  • Pages: 193-200
    |
    Published online on: January 1, 1999
       https://doi.org/10.3892/or.6.1.193
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Abstract

The p53 gene is frequently mutated in various human tumors. Polymorphism is an additional genetic alteration observed in exons and introns of the p53 gene of normal tissues and tumors. Distributions of alleles of three common polymorphisms of the p53 gene; a 16 bp duplication in intron 3, codon 72 of exon 4 and a sequence in intron 6, were studied in peripheral white blood cells (WBC) of patients with ovarian or endometrial carcinomas. The analysis was performed by PCR and direct sequencing. The 100% linkage observed between the most common haplotypes of each polymorphism in healthy subjects was lower in the patients. A significant difference was observed between frequencies of genotype and haplotype combinations in patients with ovarian carcinoma and endometrial carcinoma. The incidence of heterozygosity was increased in ovarian carcinoma and decreased in endometrial carcinoma. Our results suggest that the p53 gene may be involved in susceptibility and predisposition to various cancers not only by mutations but also by preferential presentation of polymorphic alleles.

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Copy and paste a formatted citation
Spandidos Publications style
Peller S, Halperin R, Schneider D, Kopilova Y and Rotter V: Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.. Oncol Rep 6: 193-200, 1999.
APA
Peller, S., Halperin, R., Schneider, D., Kopilova, Y., & Rotter, V. (1999). Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.. Oncology Reports, 6, 193-200. https://doi.org/10.3892/or.6.1.193
MLA
Peller, S., Halperin, R., Schneider, D., Kopilova, Y., Rotter, V."Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.". Oncology Reports 6.1 (1999): 193-200.
Chicago
Peller, S., Halperin, R., Schneider, D., Kopilova, Y., Rotter, V."Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.". Oncology Reports 6, no. 1 (1999): 193-200. https://doi.org/10.3892/or.6.1.193
Copy and paste a formatted citation
x
Spandidos Publications style
Peller S, Halperin R, Schneider D, Kopilova Y and Rotter V: Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.. Oncol Rep 6: 193-200, 1999.
APA
Peller, S., Halperin, R., Schneider, D., Kopilova, Y., & Rotter, V. (1999). Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.. Oncology Reports, 6, 193-200. https://doi.org/10.3892/or.6.1.193
MLA
Peller, S., Halperin, R., Schneider, D., Kopilova, Y., Rotter, V."Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.". Oncology Reports 6.1 (1999): 193-200.
Chicago
Peller, S., Halperin, R., Schneider, D., Kopilova, Y., Rotter, V."Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma.". Oncology Reports 6, no. 1 (1999): 193-200. https://doi.org/10.3892/or.6.1.193
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