Effect induced by interleukin-1 on the behaviour of B16F10 melanoma cells.

  • Authors:
    • A G De Galdeano
    • D Boyano
    • L Cañavate
  • View Affiliations

  • Published online on: January 1, 1999     https://doi.org/10.3892/or.6.1.225
  • Pages: 225-233
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Abstract

We have previously demonstrated that in vitro treatment with interleukins (IL-2 and IL-6) enhances metastasis in B16 murine melanoma. IL-1 has been reported to be involved in the metastatic activity of human melanoma; so in the present study we have investigated if IL-1 could also modulate the behaviour of this experimental tumor. Data showed that low doses of IL-1 induced cell proliferation and several modifications in the expression of MHC antigens, fibronectin and laminin, however these changes did not lead to a higher metastatic efficiency. In addition it was shown that B16F10 cells express IL-1 mRNA. It can be concluded that IL-1 may be involved in the biology of B16F10 cells although its role in metastasis needs further investigation.

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Jan-Feb 1999
Volume 6 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
De Galdeano A, Boyano D and Cañavate L: Effect induced by interleukin-1 on the behaviour of B16F10 melanoma cells.. Oncol Rep 6: 225-233, 1999
APA
De Galdeano, A., Boyano, D., & Cañavate, L. (1999). Effect induced by interleukin-1 on the behaviour of B16F10 melanoma cells.. Oncology Reports, 6, 225-233. https://doi.org/10.3892/or.6.1.225
MLA
De Galdeano, A., Boyano, D., Cañavate, L."Effect induced by interleukin-1 on the behaviour of B16F10 melanoma cells.". Oncology Reports 6.1 (1999): 225-233.
Chicago
De Galdeano, A., Boyano, D., Cañavate, L."Effect induced by interleukin-1 on the behaviour of B16F10 melanoma cells.". Oncology Reports 6, no. 1 (1999): 225-233. https://doi.org/10.3892/or.6.1.225