Effects of interferon-alpha on cellular proliferation and adhesion of breast carcinoma cells.

  • Authors:
    • M Maemura
    • Y Iino
    • J Horiguchi
    • H Takei
    • Y Horii
    • Y Koibuchi
    • T Yokoe
    • I Takeyoshi
    • S Ohwada
    • Y Morishita
  • View Affiliations

  • Published online on: May 1, 1999     https://doi.org/10.3892/or.6.3.557
  • Pages: 557-618
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Abstract

We examined the potent inhibitory effects of interferon-alpha (IFN-alpha) on both cellular adhesion and cell proliferation of MCF-7 breast carcinoma cells. When MCF-7 cells were exposed to IFN-alpha at a concentration of 5x10(3) IU/ml for 5 days, cell proliferation was markedly inhibited. Cell attachment assay demonstrated that incubation with IFN-alpha for up to 48 h reduced alpha2beta1 integrin-mediated cellular adhesion. However, fluorescence activated cell sorter (FACS) analysis revealed that incubation with IFN-alpha for 24 h had no effect upon the cell surface expressions of either alpha2 and beta1 integrin on MCF-7 cells. These antiproliferative and antiadhesive actions of IFN-alpha may be applied to treatment for patients with metastatic breast carcinoma.

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May-Jun 1999
Volume 6 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Maemura M, Iino Y, Horiguchi J, Takei H, Horii Y, Koibuchi Y, Yokoe T, Takeyoshi I, Ohwada S, Morishita Y, Morishita Y, et al: Effects of interferon-alpha on cellular proliferation and adhesion of breast carcinoma cells.. Oncol Rep 6: 557-618, 1999
APA
Maemura, M., Iino, Y., Horiguchi, J., Takei, H., Horii, Y., Koibuchi, Y. ... Morishita, Y. (1999). Effects of interferon-alpha on cellular proliferation and adhesion of breast carcinoma cells.. Oncology Reports, 6, 557-618. https://doi.org/10.3892/or.6.3.557
MLA
Maemura, M., Iino, Y., Horiguchi, J., Takei, H., Horii, Y., Koibuchi, Y., Yokoe, T., Takeyoshi, I., Ohwada, S., Morishita, Y."Effects of interferon-alpha on cellular proliferation and adhesion of breast carcinoma cells.". Oncology Reports 6.3 (1999): 557-618.
Chicago
Maemura, M., Iino, Y., Horiguchi, J., Takei, H., Horii, Y., Koibuchi, Y., Yokoe, T., Takeyoshi, I., Ohwada, S., Morishita, Y."Effects of interferon-alpha on cellular proliferation and adhesion of breast carcinoma cells.". Oncology Reports 6, no. 3 (1999): 557-618. https://doi.org/10.3892/or.6.3.557