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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 1999 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jul-Aug 1999 Volume 6 Issue 4

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Article

Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.

  • Authors:
    • M Kragh
    • M Spang-Thomsen
    • P E Kristjansen

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Pathology, University of Copenhagen, DK-2100, Copenhagen, Denmark.
  • Pages: 759-821
    |
    Published online on: July 1, 1999
       https://doi.org/10.3892/or.6.4.759
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Abstract

We examined the effect of the anti-angiogenic compound TNP-470 on early tumor growth characteristics following subcutaneous implantation of 1 mm3 tissue blocks of human glioblastoma U87, in nude mice. The mice received daily injections with TNP-470, 7 mg/kg, from one day before until either 3, 7, 11, or 15 days after inoculation. The time from inoculation until initiation of exponential tumor growth was determined along with the post-therapeutic growth delay and the initial tumor doubling time (TD) for each individual tumor (n=103) on the basis of tumor volume growth curves. We found that: i) the onset of growth of U87 xenografts was effectively inhibited by concurrent treatment with TNP-470 beyond the first three days after inoculation, ii) this effect was fully reversible upon termination of therapy, and iii) the post-therapeutic growth delay was independent of the accumulated dose. These findings demonstrate that the in vivo effect of TNP-470 on tumor growth is tumor inhibitory rather than cytotoxic. The lack of effect of the anti-angiogenic compound, TNP-470, in the early 3-day schedule is consistent with the existence of an early avascular phase which precede the angiogenesis-dependent tumor growth.

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Copy and paste a formatted citation
Spandidos Publications style
Kragh M, Spang-Thomsen M and Kristjansen P: Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.. Oncol Rep 6: 759-821, 1999.
APA
Kragh, M., Spang-Thomsen, M., & Kristjansen, P. (1999). Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.. Oncology Reports, 6, 759-821. https://doi.org/10.3892/or.6.4.759
MLA
Kragh, M., Spang-Thomsen, M., Kristjansen, P."Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.". Oncology Reports 6.4 (1999): 759-821.
Chicago
Kragh, M., Spang-Thomsen, M., Kristjansen, P."Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.". Oncology Reports 6, no. 4 (1999): 759-821. https://doi.org/10.3892/or.6.4.759
Copy and paste a formatted citation
x
Spandidos Publications style
Kragh M, Spang-Thomsen M and Kristjansen P: Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.. Oncol Rep 6: 759-821, 1999.
APA
Kragh, M., Spang-Thomsen, M., & Kristjansen, P. (1999). Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.. Oncology Reports, 6, 759-821. https://doi.org/10.3892/or.6.4.759
MLA
Kragh, M., Spang-Thomsen, M., Kristjansen, P."Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.". Oncology Reports 6.4 (1999): 759-821.
Chicago
Kragh, M., Spang-Thomsen, M., Kristjansen, P."Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.". Oncology Reports 6, no. 4 (1999): 759-821. https://doi.org/10.3892/or.6.4.759
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