Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.

  • Authors:
    • M Kragh
    • M Spang-Thomsen
    • P E Kristjansen
  • View Affiliations

  • Published online on: July 1, 1999     https://doi.org/10.3892/or.6.4.759
  • Pages: 759-821
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Abstract

We examined the effect of the anti-angiogenic compound TNP-470 on early tumor growth characteristics following subcutaneous implantation of 1 mm3 tissue blocks of human glioblastoma U87, in nude mice. The mice received daily injections with TNP-470, 7 mg/kg, from one day before until either 3, 7, 11, or 15 days after inoculation. The time from inoculation until initiation of exponential tumor growth was determined along with the post-therapeutic growth delay and the initial tumor doubling time (TD) for each individual tumor (n=103) on the basis of tumor volume growth curves. We found that: i) the onset of growth of U87 xenografts was effectively inhibited by concurrent treatment with TNP-470 beyond the first three days after inoculation, ii) this effect was fully reversible upon termination of therapy, and iii) the post-therapeutic growth delay was independent of the accumulated dose. These findings demonstrate that the in vivo effect of TNP-470 on tumor growth is tumor inhibitory rather than cytotoxic. The lack of effect of the anti-angiogenic compound, TNP-470, in the early 3-day schedule is consistent with the existence of an early avascular phase which precede the angiogenesis-dependent tumor growth.

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Jul-Aug 1999
Volume 6 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kragh M, Spang-Thomsen M and Kristjansen P: Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.. Oncol Rep 6: 759-821, 1999
APA
Kragh, M., Spang-Thomsen, M., & Kristjansen, P. (1999). Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.. Oncology Reports, 6, 759-821. https://doi.org/10.3892/or.6.4.759
MLA
Kragh, M., Spang-Thomsen, M., Kristjansen, P."Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.". Oncology Reports 6.4 (1999): 759-821.
Chicago
Kragh, M., Spang-Thomsen, M., Kristjansen, P."Time until initiation of tumor growth is an effective measure of the anti-angiogenic effect of TNP-470 on human glioblastoma in nude mice.". Oncology Reports 6, no. 4 (1999): 759-821. https://doi.org/10.3892/or.6.4.759