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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 1999 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jul-Aug 1999 Volume 6 Issue 4

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Article

Prognostic significance of serum LDH in Ewing's sarcoma of bone.

  • Authors:
    • G Bacci
    • S Ferrari
    • A Longhi
    • S Rimondini
    • M Versari
    • A Zanone
    • C Forni

  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
  • Pages: 807-818
    |
    Published online on: July 1, 1999
       https://doi.org/10.3892/or.6.4.807
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Abstract

The pretreatment serum lactic dehydrogenase (SLDH) levels of 618 patients with Ewing's sarcoma of the extremities (136 metastatic at presentation and 482 localized) were analyzed to evaluate whether the enzyme level had a clinical value in predicting the course of the disease. The percentage of patients with increased SLDH was significantly higher in the metastatic group than in the group of patients with localized disease (68% vs 32%; P<0.0001). In the latter group treated with neoadjuvant chemotherapy the 5-year disease-free survival rate was significantly higher in patients with normal pretreatment SLDH than in those with high levels (65% vs 41%; P<0.0001). The time to relapse was significantly shorter for patients with elevated SLDH than in patients with normal values of the enzyme. The site of the tumor was significantly related with the stage of the disease, and for patients with localized disease, with the disease survival rate, at the multivariate analyses site of the tumor and SLDH levels were independently related with the stage of disease and with prognosis. These data demonstrate that in Ewing's sarcoma of bone pretreatment SLDH have a prognostic value and should be considered in the comparison of the results achieved with different therapies and in planning new randomized clinical therapeutic trials.

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Copy and paste a formatted citation
Spandidos Publications style
Bacci G, Ferrari S, Longhi A, Rimondini S, Versari M, Zanone A and Forni C: Prognostic significance of serum LDH in Ewing's sarcoma of bone.. Oncol Rep 6: 807-818, 1999.
APA
Bacci, G., Ferrari, S., Longhi, A., Rimondini, S., Versari, M., Zanone, A., & Forni, C. (1999). Prognostic significance of serum LDH in Ewing's sarcoma of bone.. Oncology Reports, 6, 807-818. https://doi.org/10.3892/or.6.4.807
MLA
Bacci, G., Ferrari, S., Longhi, A., Rimondini, S., Versari, M., Zanone, A., Forni, C."Prognostic significance of serum LDH in Ewing's sarcoma of bone.". Oncology Reports 6.4 (1999): 807-818.
Chicago
Bacci, G., Ferrari, S., Longhi, A., Rimondini, S., Versari, M., Zanone, A., Forni, C."Prognostic significance of serum LDH in Ewing's sarcoma of bone.". Oncology Reports 6, no. 4 (1999): 807-818. https://doi.org/10.3892/or.6.4.807
Copy and paste a formatted citation
x
Spandidos Publications style
Bacci G, Ferrari S, Longhi A, Rimondini S, Versari M, Zanone A and Forni C: Prognostic significance of serum LDH in Ewing's sarcoma of bone.. Oncol Rep 6: 807-818, 1999.
APA
Bacci, G., Ferrari, S., Longhi, A., Rimondini, S., Versari, M., Zanone, A., & Forni, C. (1999). Prognostic significance of serum LDH in Ewing's sarcoma of bone.. Oncology Reports, 6, 807-818. https://doi.org/10.3892/or.6.4.807
MLA
Bacci, G., Ferrari, S., Longhi, A., Rimondini, S., Versari, M., Zanone, A., Forni, C."Prognostic significance of serum LDH in Ewing's sarcoma of bone.". Oncology Reports 6.4 (1999): 807-818.
Chicago
Bacci, G., Ferrari, S., Longhi, A., Rimondini, S., Versari, M., Zanone, A., Forni, C."Prognostic significance of serum LDH in Ewing's sarcoma of bone.". Oncology Reports 6, no. 4 (1999): 807-818. https://doi.org/10.3892/or.6.4.807
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