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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 1999 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Jul-Aug 1999 Volume 6 Issue 4

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Article

High resolution mapping of chromosome 6 deletions in cervical cancer.

  • Authors:
    • N Mazurenko
    • M Attaleb
    • T Gritsko
    • L Semjonova
    • L Pavlova
    • O Sakharova
    • F Kisseljov

  • View Affiliations / Copyright

    Affiliations: Division of Tumor Transforming Genes, Institute of Carcinogenesis, Blokhin Cancer Research Center, 115478 Moscow, Russia.
  • Pages: 859-922
    |
    Published online on: July 1, 1999
       https://doi.org/10.3892/or.6.4.859
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Abstract

Chromosome 6 is frequently affected in different tumors. However, little information exists on chromosome 6 deletions in cervical cancer. We have studied loss of heterozygosity (LOH) and microsatellite instability (MIN) in 62 invasive squamous cell carcinomas of the cervix (CC) using 19 polymorphic microsatellite markers spanning both arms of chromosome 6 and one marker located at 5p15. We found that LOH at chromosome 6 is a common feature of cervical carcinomas: 90% (56/62) of CC had LOH at least at one locus and about 58% (36/62) had LOH on both arms of chromosome 6. The highest LOH incidence was shown in HLA region (6p21.3-6p21.1) with markers D6S273 and D6S276 in 52.7% and 45.2% of informative cases respectively. Frequent LOH on 6q was found at loci D6S311 (6q24-25. 1), D6S305 (6q26) and D6S281 (6q27-6qter) in 37.8%, 33.3% and 39.0% of informative cases respectively. There was no significant correlation observed between clinical parameters of cervical cancer (age, histologic grade, clinical stages and progression) and LOH frequency. Microsatellite instability was found in 3 out of 62 cases (4.8%) at three and more loci out of 20 tested. The study shows that several regions on 6p and 6q may harbour potential tumor-suppressor genes important for cervical cancer progression.

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Copy and paste a formatted citation
Spandidos Publications style
Mazurenko N, Attaleb M, Gritsko T, Semjonova L, Pavlova L, Sakharova O and Kisseljov F: High resolution mapping of chromosome 6 deletions in cervical cancer.. Oncol Rep 6: 859-922, 1999.
APA
Mazurenko, N., Attaleb, M., Gritsko, T., Semjonova, L., Pavlova, L., Sakharova, O., & Kisseljov, F. (1999). High resolution mapping of chromosome 6 deletions in cervical cancer.. Oncology Reports, 6, 859-922. https://doi.org/10.3892/or.6.4.859
MLA
Mazurenko, N., Attaleb, M., Gritsko, T., Semjonova, L., Pavlova, L., Sakharova, O., Kisseljov, F."High resolution mapping of chromosome 6 deletions in cervical cancer.". Oncology Reports 6.4 (1999): 859-922.
Chicago
Mazurenko, N., Attaleb, M., Gritsko, T., Semjonova, L., Pavlova, L., Sakharova, O., Kisseljov, F."High resolution mapping of chromosome 6 deletions in cervical cancer.". Oncology Reports 6, no. 4 (1999): 859-922. https://doi.org/10.3892/or.6.4.859
Copy and paste a formatted citation
x
Spandidos Publications style
Mazurenko N, Attaleb M, Gritsko T, Semjonova L, Pavlova L, Sakharova O and Kisseljov F: High resolution mapping of chromosome 6 deletions in cervical cancer.. Oncol Rep 6: 859-922, 1999.
APA
Mazurenko, N., Attaleb, M., Gritsko, T., Semjonova, L., Pavlova, L., Sakharova, O., & Kisseljov, F. (1999). High resolution mapping of chromosome 6 deletions in cervical cancer.. Oncology Reports, 6, 859-922. https://doi.org/10.3892/or.6.4.859
MLA
Mazurenko, N., Attaleb, M., Gritsko, T., Semjonova, L., Pavlova, L., Sakharova, O., Kisseljov, F."High resolution mapping of chromosome 6 deletions in cervical cancer.". Oncology Reports 6.4 (1999): 859-922.
Chicago
Mazurenko, N., Attaleb, M., Gritsko, T., Semjonova, L., Pavlova, L., Sakharova, O., Kisseljov, F."High resolution mapping of chromosome 6 deletions in cervical cancer.". Oncology Reports 6, no. 4 (1999): 859-922. https://doi.org/10.3892/or.6.4.859
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