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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 1999 Volume 6 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.

  • Authors:
    • L E Davel
    • L I Puricelli
    • M Del Carmen C Vidal
    • M S De Lorenzo
    • E Sacerdote de Lustig
    • E D Bal de Kier Joffe

  • View Affiliations / Copyright

    Affiliations: Area Investigacion, Instituto de Oncologia 'Angel H. Roffo', UBA, 1417 Buenos Aires, Argentina.
  • Pages: 907-918
    |
    Published online on: July 1, 1999
       https://doi.org/10.3892/or.6.4.907
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Abstract

The ability of tumor cells to respond to microenvironmental factors present in the target organ determines in part the successful development of a metastasis. In a previous work it was demonstrated that the conditioned medium (CM) from lungs of normal mice stimulates in vitro migration, proliferation and uPA activity of cells from a murine mammary adenocarcinoma moderately metastatic to lung. This CM also enhanced local and metastatic tumor growth. Here, we show that lung CM enhanced neovascularization when inoculated together with LM3 tumor cells into the skin of syngeneic mice. A similar tumor-induced angiogenesis response was obtained when lung CM was injected systemically. Western blot analysis of lung CM revealed the presence of some laminin fragments containing the sequence SIKVAV. To determine whether those molecules were responsible for the observed angiogenic effects, the CM was depleted of the peptides containing the SIKVAV sequence. We observed that the SIKVAV-depleted lung CM lost its ability to induce an enhancement of the tumor neovascular response. Our results suggest a role for the target organ in facilitating the neovascularization of tumor cells, probably through the participation of active peptides derived from the proteolytic degradation of the basement membrane component laminin.

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Copy and paste a formatted citation
Spandidos Publications style
Davel L, Puricelli L, Del Carmen C Vidal M, De Lorenzo M, Sacerdote de Lustig E and Bal de Kier Joffe E: Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.. Oncol Rep 6: 907-918, 1999.
APA
Davel, L., Puricelli, L., Del Carmen C Vidal, M., De Lorenzo, M., Sacerdote de Lustig, E., & Bal de Kier Joffe, E. (1999). Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.. Oncology Reports, 6, 907-918. https://doi.org/10.3892/or.6.4.907
MLA
Davel, L., Puricelli, L., Del Carmen C Vidal, M., De Lorenzo, M., Sacerdote de Lustig, E., Bal de Kier Joffe, E."Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.". Oncology Reports 6.4 (1999): 907-918.
Chicago
Davel, L., Puricelli, L., Del Carmen C Vidal, M., De Lorenzo, M., Sacerdote de Lustig, E., Bal de Kier Joffe, E."Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.". Oncology Reports 6, no. 4 (1999): 907-918. https://doi.org/10.3892/or.6.4.907
Copy and paste a formatted citation
x
Spandidos Publications style
Davel L, Puricelli L, Del Carmen C Vidal M, De Lorenzo M, Sacerdote de Lustig E and Bal de Kier Joffe E: Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.. Oncol Rep 6: 907-918, 1999.
APA
Davel, L., Puricelli, L., Del Carmen C Vidal, M., De Lorenzo, M., Sacerdote de Lustig, E., & Bal de Kier Joffe, E. (1999). Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.. Oncology Reports, 6, 907-918. https://doi.org/10.3892/or.6.4.907
MLA
Davel, L., Puricelli, L., Del Carmen C Vidal, M., De Lorenzo, M., Sacerdote de Lustig, E., Bal de Kier Joffe, E."Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.". Oncology Reports 6.4 (1999): 907-918.
Chicago
Davel, L., Puricelli, L., Del Carmen C Vidal, M., De Lorenzo, M., Sacerdote de Lustig, E., Bal de Kier Joffe, E."Soluble factors from the target organ enhance tumor cell angiogenesis: role of laminin SIKVAV sequence.". Oncology Reports 6, no. 4 (1999): 907-918. https://doi.org/10.3892/or.6.4.907
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