Activation of autologous or HLA-identical sibling cytotoxic T lymphocytes by blood derived dendritic cells pulsed with tumor cell extracts.

  • Authors:
    • Y Osman
    • M Takahashi
    • Z Zheng
    • K Toba
    • A Liu
    • T Furukawa
    • Y Aizawa
    • A Shibata
    • T Koike
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/or.6.5.1057
  • Pages: 1057-1120
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Abstract

This study describes the effect of dendritic cells (DC) pulsed with tumor cell extracts on the induction and activation of autologous and HLA-identical sibling tumor cell specific cytotoxic T lymphocytes (CTL). The subjects of the study were patients with hematological malignancies (acute myeloid leukemia, acute lymphoblastic leukemia, and multiple myeloma), and stem cell transplant donors. Although lymphocytes primed with non-pulsed DC did not show definite cytotoxic activity against autologous or HLA-identical sibling patient tumor cells, both autologous and HLA-identical sibling CTL activated by DC pulsed with tumor cell extracts demonstrated markedly significant killing activity against tumor cells in the fashion of higher cytotoxicity with the increase of effector:target ratio (p<0.05). These findings reveal that DC pulsed with tumor cell extracts could be efficiently applicable in anti-tumor immunotherapy for patients with hematological malignancies.

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Sep-Oct 1999
Volume 6 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Osman Y, Takahashi M, Zheng Z, Toba K, Liu A, Furukawa T, Aizawa Y, Shibata A and Koike T: Activation of autologous or HLA-identical sibling cytotoxic T lymphocytes by blood derived dendritic cells pulsed with tumor cell extracts.. Oncol Rep 6: 1057-1120, 1999
APA
Osman, Y., Takahashi, M., Zheng, Z., Toba, K., Liu, A., Furukawa, T. ... Koike, T. (1999). Activation of autologous or HLA-identical sibling cytotoxic T lymphocytes by blood derived dendritic cells pulsed with tumor cell extracts.. Oncology Reports, 6, 1057-1120. https://doi.org/10.3892/or.6.5.1057
MLA
Osman, Y., Takahashi, M., Zheng, Z., Toba, K., Liu, A., Furukawa, T., Aizawa, Y., Shibata, A., Koike, T."Activation of autologous or HLA-identical sibling cytotoxic T lymphocytes by blood derived dendritic cells pulsed with tumor cell extracts.". Oncology Reports 6.5 (1999): 1057-1120.
Chicago
Osman, Y., Takahashi, M., Zheng, Z., Toba, K., Liu, A., Furukawa, T., Aizawa, Y., Shibata, A., Koike, T."Activation of autologous or HLA-identical sibling cytotoxic T lymphocytes by blood derived dendritic cells pulsed with tumor cell extracts.". Oncology Reports 6, no. 5 (1999): 1057-1120. https://doi.org/10.3892/or.6.5.1057