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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Sep-Oct 1999 Volume 6 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Sep-Oct 1999 Volume 6 Issue 5

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Article

Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.

  • Authors:
    • P Tan
    • G Ho
    • C Ji
    • E Ng
    • F Gao
    • B Bay
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Singapore General Hospital, S169608, Singapore.
  • Pages: 1159-1222
    |
    Published online on: September 1, 1999
       https://doi.org/10.3892/or.6.5.1159
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Abstract

The results of immunohistochemical expression of p53 protein in 106 invasive breast cancers were correlated with conventional pathologic prognostic parameters. Archival formalin-fixed, paraffin-embedded tissue sections of these cases were stained with a monoclonal antibody (Ab-2), raised against p53 protein using a peroxidase-labelled streptavidin biotin kit. Fifty-six (53%) showed positive nuclear staining; 31 were considered weakly, 21 moderately and 4 strongly positive. Forty-three (77%) of these positive cases stained less than 50% of the tumor cells, with a significant association between intensity and proportion of nuclei stained (p<0. 05). p53 staining also correlated with histologic grade (p<0.005) but not with tumor size nor clinical stage (p>0.05). The follow-up data did not reveal any statistically significant survival advantage for patients with p53 negative tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Tan P, Ho G, Ji C, Ng E, Gao F and Bay B: Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.. Oncol Rep 6: 1159-1222, 1999.
APA
Tan, P., Ho, G., Ji, C., Ng, E., Gao, F., & Bay, B. (1999). Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.. Oncology Reports, 6, 1159-1222. https://doi.org/10.3892/or.6.5.1159
MLA
Tan, P., Ho, G., Ji, C., Ng, E., Gao, F., Bay, B."Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.". Oncology Reports 6.5 (1999): 1159-1222.
Chicago
Tan, P., Ho, G., Ji, C., Ng, E., Gao, F., Bay, B."Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.". Oncology Reports 6, no. 5 (1999): 1159-1222. https://doi.org/10.3892/or.6.5.1159
Copy and paste a formatted citation
x
Spandidos Publications style
Tan P, Ho G, Ji C, Ng E, Gao F and Bay B: Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.. Oncol Rep 6: 1159-1222, 1999.
APA
Tan, P., Ho, G., Ji, C., Ng, E., Gao, F., & Bay, B. (1999). Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.. Oncology Reports, 6, 1159-1222. https://doi.org/10.3892/or.6.5.1159
MLA
Tan, P., Ho, G., Ji, C., Ng, E., Gao, F., Bay, B."Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.". Oncology Reports 6.5 (1999): 1159-1222.
Chicago
Tan, P., Ho, G., Ji, C., Ng, E., Gao, F., Bay, B."Immunohistochemical expression of p53 protein in invasive breast carcinoma: clinicopathologic correlations.". Oncology Reports 6, no. 5 (1999): 1159-1222. https://doi.org/10.3892/or.6.5.1159
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