Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma.

  • Authors:
    • W Yasui
    • K Naka
    • T Suzuki
    • J Fujimoto
    • K Hayashi
    • N Matsutani
    • H Yokozaki
    • E Tahara
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/or.6.5.983
  • Pages: 983-990
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Abstract

The cell cycle is controlled by positive and negative regulators. Gene abnormalities and aberrant expressions of various cyclins/CDKs and CDK inhibitors may play a pivotal role in stomach carcinogenesis. To clarify the role of cyclin E, CDK inhibitor p27Kip1 and their target molecule, E2F-1 in tumor metastasis, we examined immunohistochemically the expression of cyclin E, p27Kip1 and E2F-1 in 23 gastric carcinomas and metastatic tumors of the lymph node. Most of gastric carcinomas with lymph node metastasis showed reduced p27Kip1 expression. p27Kip1 was negative in 39% (9/23) of primary tumors, while it was so in 52% (12/23) of lymph node metastases. By comparison of p27Kip1 expression in primary and metastatic tumors in individual cases, metastatic tumor cells in the lymph nodes were expressed at weaker levels than in those in primary tumors in 43% (10/23) of the cases. On the other hand, over 70% (17/23) and 50% (12/23) of the cases expressed cyclin E and E2F-1 at nearly the same levels in both primary tumor and lymph node metastasis, respectively. These results suggest that tumor cells with reduced p27Kip1 expression may selectively metastasize to lymph node or distant organs.

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Sep-Oct 1999
Volume 6 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yasui W, Naka K, Suzuki T, Fujimoto J, Hayashi K, Matsutani N, Yokozaki H and Tahara E: Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma.. Oncol Rep 6: 983-990, 1999
APA
Yasui, W., Naka, K., Suzuki, T., Fujimoto, J., Hayashi, K., Matsutani, N. ... Tahara, E. (1999). Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma.. Oncology Reports, 6, 983-990. https://doi.org/10.3892/or.6.5.983
MLA
Yasui, W., Naka, K., Suzuki, T., Fujimoto, J., Hayashi, K., Matsutani, N., Yokozaki, H., Tahara, E."Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma.". Oncology Reports 6.5 (1999): 983-990.
Chicago
Yasui, W., Naka, K., Suzuki, T., Fujimoto, J., Hayashi, K., Matsutani, N., Yokozaki, H., Tahara, E."Expression of p27Kip1, cyclin E and E2F-1 in primary and metastatic tumors of gastric carcinoma.". Oncology Reports 6, no. 5 (1999): 983-990. https://doi.org/10.3892/or.6.5.983