Thymidine phosphorylase activity and angiogenesis in gastric cancer.

  • Authors:
    • Y Kakeji
    • Y Maehara
    • M Tomoda
    • A Kabashima
    • S Oda
    • T Ooshiro
    • H Baba
    • S Kohnoe
    • K Sugimachi
  • View Affiliations

  • Published online on: September 1, 1999     https://doi.org/10.3892/or.6.5.995
  • Pages: 995-1004
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Abstract

Angiogenesis has an important role in the growth and metastasis of solid tumors. Several angiogenic factors have been identified, one being platelet-derived endothelial cell growth factor (PD-ECGF), which is identical to thymidine phosphorylase (dThdPase). We investigated the activity of dThdPase in 84 samples of 42 human gastric cancers, by liquid chromatography. The dThdPase activity significantly correlated to the microvessel density assessed by immunostaining to CD-31 antigen (P<0.05). Expression of dThdPase has an important role in the promotion of angiogenesis in human gastric cancer.

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Sep-Oct 1999
Volume 6 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kakeji Y, Maehara Y, Tomoda M, Kabashima A, Oda S, Ooshiro T, Baba H, Kohnoe S and Sugimachi K: Thymidine phosphorylase activity and angiogenesis in gastric cancer.. Oncol Rep 6: 995-1004, 1999
APA
Kakeji, Y., Maehara, Y., Tomoda, M., Kabashima, A., Oda, S., Ooshiro, T. ... Sugimachi, K. (1999). Thymidine phosphorylase activity and angiogenesis in gastric cancer.. Oncology Reports, 6, 995-1004. https://doi.org/10.3892/or.6.5.995
MLA
Kakeji, Y., Maehara, Y., Tomoda, M., Kabashima, A., Oda, S., Ooshiro, T., Baba, H., Kohnoe, S., Sugimachi, K."Thymidine phosphorylase activity and angiogenesis in gastric cancer.". Oncology Reports 6.5 (1999): 995-1004.
Chicago
Kakeji, Y., Maehara, Y., Tomoda, M., Kabashima, A., Oda, S., Ooshiro, T., Baba, H., Kohnoe, S., Sugimachi, K."Thymidine phosphorylase activity and angiogenesis in gastric cancer.". Oncology Reports 6, no. 5 (1999): 995-1004. https://doi.org/10.3892/or.6.5.995