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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jan-Feb 2000 Volume 7 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.

  • Authors:
    • A Takagi
    • A Imai
    • T Tamaya
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 500-8705, Japan.
  • Pages: 125-134
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/or.7.1.125
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Abstract

Gonadotropin-releasing hormone (GnRH) receptor is demonstrated in uterine endometrial carcinoma. The endometrial carcinoma also produces GnRH or -like peptide, which prompted us to examine whether the intratumoral serves as natural ligand for its receptor. Endometrial carcinomas surgically removed had been screened for GnRH receptor expression before analysis. The in endometrial carcinoma cell-enriched culture media was characterized by immunoblots in tricine-supplied electrophoresis system and subsequent amino acid sequencing. Three major proteins of 10.0 kDa, 7.6 kDa and 1.1 kDa corresponding to pre-proGnRH, proGnRH and decapeptide GnRH, respectively, were detected in all of the ten endometrial carcinoma specimens tested. Immunoreactive contents in the culture media, assessed by RIA, ranged from 0.08 to 0.1 nM. In chorionic cell-conditioned media, only 1.1-kDa protein was detected. Endometrial carcinoma cells secrete alternative GnRH processing products in addition to natural GnRH. The GnRH variants may compete with mature GnRH at the level of its receptors, perhaps counteracting the GnRH signaling pathway to retard cell proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
Takagi A, Imai A and Tamaya T: Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.. Oncol Rep 7: 125-134, 2000.
APA
Takagi, A., Imai, A., & Tamaya, T. (2000). Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.. Oncology Reports, 7, 125-134. https://doi.org/10.3892/or.7.1.125
MLA
Takagi, A., Imai, A., Tamaya, T."Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.". Oncology Reports 7.1 (2000): 125-134.
Chicago
Takagi, A., Imai, A., Tamaya, T."Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.". Oncology Reports 7, no. 1 (2000): 125-134. https://doi.org/10.3892/or.7.1.125
Copy and paste a formatted citation
x
Spandidos Publications style
Takagi A, Imai A and Tamaya T: Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.. Oncol Rep 7: 125-134, 2000.
APA
Takagi, A., Imai, A., & Tamaya, T. (2000). Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.. Oncology Reports, 7, 125-134. https://doi.org/10.3892/or.7.1.125
MLA
Takagi, A., Imai, A., Tamaya, T."Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.". Oncology Reports 7.1 (2000): 125-134.
Chicago
Takagi, A., Imai, A., Tamaya, T."Alternative gonadotropin-releasing hormone processing products secreted from endometrial carcinoma.". Oncology Reports 7, no. 1 (2000): 125-134. https://doi.org/10.3892/or.7.1.125
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