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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jan-Feb 2000 Volume 7 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.

  • Authors:
    • H B Grossman
    • C Lee
    • J Bromberg
    • M Liebert

  • View Affiliations / Copyright

    Affiliations: Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
  • Pages: 13-19
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/or.7.1.13
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Abstract

Integrins are cell surface receptors for extracellular matrix components that may participate in metastatic processes. Normal urothelial tissues show a polarized expression of alpha6beta4 integrin on basal cells at their junction with the lamina propria. We have previously shown that bladder cancers frequently overexpress one member of the integrin family, the alpha6beta4 integrin. In this study, we evaluated the level of alpha6beta4 integrin expression in bladder cancer specimens from 57 patients and correlated the expression level with patient survival. Expression was evaluated by immunoperoxidase staining. Three patterns of alpha6beta4 expression were observed: negative (13 patients); strong overexpression throughout the tumor cells (21 patients); and weak expression that most closely resembled expression in normal urothelium (23 patients). Individuals with weak staining tumors had a statistically significantly better survival (p=0.041) than patients whose tumors exhibited either no expression or strong overexpression. These data indicate that evaluation of the expression of alpha6beta4 integrin may provide valuable prognostic information on clinical outcome in patients with bladder cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Grossman H, Lee C, Bromberg J and Liebert M: Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.. Oncol Rep 7: 13-19, 2000.
APA
Grossman, H., Lee, C., Bromberg, J., & Liebert, M. (2000). Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.. Oncology Reports, 7, 13-19. https://doi.org/10.3892/or.7.1.13
MLA
Grossman, H., Lee, C., Bromberg, J., Liebert, M."Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.". Oncology Reports 7.1 (2000): 13-19.
Chicago
Grossman, H., Lee, C., Bromberg, J., Liebert, M."Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.". Oncology Reports 7, no. 1 (2000): 13-19. https://doi.org/10.3892/or.7.1.13
Copy and paste a formatted citation
x
Spandidos Publications style
Grossman H, Lee C, Bromberg J and Liebert M: Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.. Oncol Rep 7: 13-19, 2000.
APA
Grossman, H., Lee, C., Bromberg, J., & Liebert, M. (2000). Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.. Oncology Reports, 7, 13-19. https://doi.org/10.3892/or.7.1.13
MLA
Grossman, H., Lee, C., Bromberg, J., Liebert, M."Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.". Oncology Reports 7.1 (2000): 13-19.
Chicago
Grossman, H., Lee, C., Bromberg, J., Liebert, M."Expression of the alpha6beta4 integrin provides prognostic information in bladder cancer.". Oncology Reports 7, no. 1 (2000): 13-19. https://doi.org/10.3892/or.7.1.13
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