Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.

  • Authors:
    • J Golab
    • R Zagozdzon
    • K Kozar
    • R Kaminski
    • A Giermasz
    • T Stoklosa
    • W Lasek
    • M Jakobisiak
  • View Affiliations

  • Published online on: January 1, 2000     https://doi.org/10.3892/or.7.1.177
  • Pages: 177-258
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Abstract

In previous studies we have shown that combined chemo-immunotherapy of L1210 leukemia with IL-12 and doxorubicin results in striking anti-tumor effects producing 100% of long-term survivors. In this study we investigated the efficacy of a combination of IL-12 and mitoxantrone in murine L1210 leukemia. Mice inoculated with 1x105 leukemia cells were treated with a single dose of mitoxantrone and seven daily doses of IL-12, and were daily observed for survival. Treatment with IL-12 or mitoxantrone given alone produced moderate anti-leukemic effects. However, combination of both drugs resulted in a significant prolongation of mouse survival time. Importantly, there were almost 50% of long-term (>60 days) survivors among the mice treated with both agents. This therapeutic effect was completely abrogated by sub-lethal, whole-body X-irradiation, and significantly reduced after macrophage depletion.

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Jan-Feb 2000
Volume 7 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Golab J, Zagozdzon R, Kozar K, Kaminski R, Giermasz A, Stoklosa T, Lasek W and Jakobisiak M: Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.. Oncol Rep 7: 177-258, 2000
APA
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T. ... Jakobisiak, M. (2000). Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.. Oncology Reports, 7, 177-258. https://doi.org/10.3892/or.7.1.177
MLA
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T., Lasek, W., Jakobisiak, M."Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.". Oncology Reports 7.1 (2000): 177-258.
Chicago
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T., Lasek, W., Jakobisiak, M."Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.". Oncology Reports 7, no. 1 (2000): 177-258. https://doi.org/10.3892/or.7.1.177