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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jan-Feb 2000 Volume 7 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.

  • Authors:
    • J Golab
    • R Zagozdzon
    • K Kozar
    • R Kaminski
    • A Giermasz
    • T Stoklosa
    • W Lasek
    • M Jakobisiak
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Institute of Biostructure, The Medical University of Warsaw, Warsaw 02-004, Poland.
  • Pages: 177-258
    |
    Published online on: January 1, 2000
       https://doi.org/10.3892/or.7.1.177
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Abstract

In previous studies we have shown that combined chemo-immunotherapy of L1210 leukemia with IL-12 and doxorubicin results in striking anti-tumor effects producing 100% of long-term survivors. In this study we investigated the efficacy of a combination of IL-12 and mitoxantrone in murine L1210 leukemia. Mice inoculated with 1x105 leukemia cells were treated with a single dose of mitoxantrone and seven daily doses of IL-12, and were daily observed for survival. Treatment with IL-12 or mitoxantrone given alone produced moderate anti-leukemic effects. However, combination of both drugs resulted in a significant prolongation of mouse survival time. Importantly, there were almost 50% of long-term (>60 days) survivors among the mice treated with both agents. This therapeutic effect was completely abrogated by sub-lethal, whole-body X-irradiation, and significantly reduced after macrophage depletion.

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Copy and paste a formatted citation
Spandidos Publications style
Golab J, Zagozdzon R, Kozar K, Kaminski R, Giermasz A, Stoklosa T, Lasek W and Jakobisiak M: Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.. Oncol Rep 7: 177-258, 2000.
APA
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T. ... Jakobisiak, M. (2000). Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.. Oncology Reports, 7, 177-258. https://doi.org/10.3892/or.7.1.177
MLA
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T., Lasek, W., Jakobisiak, M."Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.". Oncology Reports 7.1 (2000): 177-258.
Chicago
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T., Lasek, W., Jakobisiak, M."Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.". Oncology Reports 7, no. 1 (2000): 177-258. https://doi.org/10.3892/or.7.1.177
Copy and paste a formatted citation
x
Spandidos Publications style
Golab J, Zagozdzon R, Kozar K, Kaminski R, Giermasz A, Stoklosa T, Lasek W and Jakobisiak M: Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.. Oncol Rep 7: 177-258, 2000.
APA
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T. ... Jakobisiak, M. (2000). Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.. Oncology Reports, 7, 177-258. https://doi.org/10.3892/or.7.1.177
MLA
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T., Lasek, W., Jakobisiak, M."Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.". Oncology Reports 7.1 (2000): 177-258.
Chicago
Golab, J., Zagozdzon, R., Kozar, K., Kaminski, R., Giermasz, A., Stoklosa, T., Lasek, W., Jakobisiak, M."Potentiatied anti-tumor effectiveness of combined therapy with interleukin-12 and mitoxantrone of L1210 leukemia in vivo.". Oncology Reports 7, no. 1 (2000): 177-258. https://doi.org/10.3892/or.7.1.177
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