Prognostic relevance of c-Myc and caspase-3 for patients with non-small cell lung cancer.

  • Authors:
    • M Volm
    • R Koomagi
  • View Affiliations

  • Published online on: January 1, 2000     https://doi.org/10.3892/or.7.1.95
  • Pages: 95-103
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Abstract

This analysis attempted to ascertain whether combining the expression of c-Myc and caspase-3 can improve the available prognostic information for patients with non-small cell lung carcinomas. To this purpose, the expression of c-Myc and caspase-3 was determined in 128 cases of non-small cell lung carcinoma. The median survival time for patients with c-Myc-negative carcinomas was 89 weeks; it was only 43 weeks for patients with c-Myc-positive tumors (p=0.03). The estimated increased relative risk for patients with c-Myc-positive tumors was 1.6. The median survival time for patients with caspase-3-negative carcinomas was 41 weeks while patients with caspase-3-positive carcinomas survived for 79 weeks (p=0.06). The relative risk for patients with caspase-3-negative tumors was 1.5. A significant inverse relationship between the expression of c-Myc and caspase-3 was observed (p=0.04). To determine whether the combination of c-Myc and caspase-3 expression has a higher prognostic significance, patients were grouped based on their expressions of both variables. Patients with c-Myc-negative and caspase-3-positive tumors had the most favorable prognosis (102 weeks) while c-Myc-positive and caspase-3-negative carcinomas had the most unfavorable prognosis (22 weeks; p=0.01).

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Jan-Feb 2000
Volume 7 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Volm M and Volm M: Prognostic relevance of c-Myc and caspase-3 for patients with non-small cell lung cancer.. Oncol Rep 7: 95-103, 2000
APA
Volm, M., & Volm, M. (2000). Prognostic relevance of c-Myc and caspase-3 for patients with non-small cell lung cancer.. Oncology Reports, 7, 95-103. https://doi.org/10.3892/or.7.1.95
MLA
Volm, M., Koomagi, R."Prognostic relevance of c-Myc and caspase-3 for patients with non-small cell lung cancer.". Oncology Reports 7.1 (2000): 95-103.
Chicago
Volm, M., Koomagi, R."Prognostic relevance of c-Myc and caspase-3 for patients with non-small cell lung cancer.". Oncology Reports 7, no. 1 (2000): 95-103. https://doi.org/10.3892/or.7.1.95