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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Mar-Apr 2000 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.

  • Authors:
    • K Wakabayashi
    • H Saito
    • H Ebinuma
    • Y Saito
    • T Takagi
    • M Nakamura
    • A Umezawa
    • J Hata
    • H Ishii
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160-8582, Japan.
  • Pages: 285-293
    |
    Published online on: March 1, 2000
       https://doi.org/10.3892/or.7.2.285
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Abstract

Expression of the Bcl-2 family members in a human hepatocellular carcinoma cell line (HCC-T) after sodium butyrate-treatment was investigated. Sodium butyrate, a histone deacetylase inhibitor, induced differentiation of the cell line into its normal counterpart without inducing apoptosis at the concentration of 2 mmol/l. Since sodium butyrate has effects on both differentiation and apoptosis, we investigated the expression profile of bcl-2 related genes in HCC-T. The expression of Bcl-2 and Mcl-1/EAT was up-regulated 4-12 h after the treatment while Bcl-XL was up-regulated 2-3 days after the stimulation. On the other hand, the expression levels of Bax protein remained unchanged during differentiation. The HCC-T cells entered a cell cycle arrest at G1 and showed neither cellular fragmentation nor apoptosis during this period, which was concomitantly associated with up-regulated expression of a cell cycle regulator, p21WAF-1. These results demonstrate that induction of anti-apoptotic bcl-2 related proteins at an early stage of differentiation is important for the maintenance of HCC-T cell differentiation by antagonizing pro-apoptotic molecules such as Bax.

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Copy and paste a formatted citation
Spandidos Publications style
Wakabayashi K, Saito H, Ebinuma H, Saito Y, Takagi T, Nakamura M, Umezawa A, Hata J and Ishii H: Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.. Oncol Rep 7: 285-293, 2000.
APA
Wakabayashi, K., Saito, H., Ebinuma, H., Saito, Y., Takagi, T., Nakamura, M. ... Ishii, H. (2000). Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.. Oncology Reports, 7, 285-293. https://doi.org/10.3892/or.7.2.285
MLA
Wakabayashi, K., Saito, H., Ebinuma, H., Saito, Y., Takagi, T., Nakamura, M., Umezawa, A., Hata, J., Ishii, H."Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.". Oncology Reports 7.2 (2000): 285-293.
Chicago
Wakabayashi, K., Saito, H., Ebinuma, H., Saito, Y., Takagi, T., Nakamura, M., Umezawa, A., Hata, J., Ishii, H."Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.". Oncology Reports 7, no. 2 (2000): 285-293. https://doi.org/10.3892/or.7.2.285
Copy and paste a formatted citation
x
Spandidos Publications style
Wakabayashi K, Saito H, Ebinuma H, Saito Y, Takagi T, Nakamura M, Umezawa A, Hata J and Ishii H: Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.. Oncol Rep 7: 285-293, 2000.
APA
Wakabayashi, K., Saito, H., Ebinuma, H., Saito, Y., Takagi, T., Nakamura, M. ... Ishii, H. (2000). Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.. Oncology Reports, 7, 285-293. https://doi.org/10.3892/or.7.2.285
MLA
Wakabayashi, K., Saito, H., Ebinuma, H., Saito, Y., Takagi, T., Nakamura, M., Umezawa, A., Hata, J., Ishii, H."Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.". Oncology Reports 7.2 (2000): 285-293.
Chicago
Wakabayashi, K., Saito, H., Ebinuma, H., Saito, Y., Takagi, T., Nakamura, M., Umezawa, A., Hata, J., Ishii, H."Bcl-2 related proteins are dramatically induced at the early stage of differentiation in human liver cancer cells by a histone deacetylase inhibitor projecting an anti-apoptotic role during this period.". Oncology Reports 7, no. 2 (2000): 285-293. https://doi.org/10.3892/or.7.2.285
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