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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Mar-Apr 2000 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.

  • Authors:
    • T Ikeda
    • K Yoshinaga
    • S Semba
    • E Kondo
    • H Ohmori
    • A Horii

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Tohoku University School of Medicine, Sendai 980-8575, Japan.
  • Pages: 323-329
    |
    Published online on: March 1, 2000
       https://doi.org/10.3892/or.7.2.323
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Abstract

Recently, CTNNB1 (beta-catenin) has been found to function as an oncoprotein that works in the Wnt signaling pathway, and mutation of this gene has been reported in various human cancers. In this study, we analyzed 44 endometrial cancers and found somatic missense mutations in five (11%) tumors. Interestingly, four (80%) of the five tumors with mutations would cause amino acid alterations at residues next to Ser 33, one of the targets for phosphorylation of glycogen synthase kinase (GSK)-3beta. The tumors with mutations showed accumulation of the CTNNB1 protein in cytoplasm and nucleus. This is the first report of frequent somatic mutation of the CTNNB1 gene at codons adjacent to those encoding to Ser/Thr residues in endometrial cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Ikeda T, Yoshinaga K, Semba S, Kondo E, Ohmori H and Horii A: Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.. Oncol Rep 7: 323-329, 2000.
APA
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., & Horii, A. (2000). Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.. Oncology Reports, 7, 323-329. https://doi.org/10.3892/or.7.2.323
MLA
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A."Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.". Oncology Reports 7.2 (2000): 323-329.
Chicago
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A."Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.". Oncology Reports 7, no. 2 (2000): 323-329. https://doi.org/10.3892/or.7.2.323
Copy and paste a formatted citation
x
Spandidos Publications style
Ikeda T, Yoshinaga K, Semba S, Kondo E, Ohmori H and Horii A: Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.. Oncol Rep 7: 323-329, 2000.
APA
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., & Horii, A. (2000). Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.. Oncology Reports, 7, 323-329. https://doi.org/10.3892/or.7.2.323
MLA
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A."Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.". Oncology Reports 7.2 (2000): 323-329.
Chicago
Ikeda, T., Yoshinaga, K., Semba, S., Kondo, E., Ohmori, H., Horii, A."Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation.". Oncology Reports 7, no. 2 (2000): 323-329. https://doi.org/10.3892/or.7.2.323
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