Clinical significance of serum vascular endothelial growth factor in colorectal cancer patients: correlation with clinicopathological factors and tumor markers.

Takeda,A; Shimada,H; Imaseki,H; Okazumi,S; Natsume,T; Suzuki,T; Ochiai,T

doi:10.3892/or.7.2.333

Mar-Apr 2000 Volume 7 Issue 2

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Mar-Apr 2000 Volume 7 Issue 2

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Article

Clinical significance of serum vascular endothelial growth factor in colorectal cancer patients: correlation with clinicopathological factors and tumor markers.

Authors:
- A Takeda
- H Shimada
- H Imaseki
- S Okazumi
- T Natsume
- T Suzuki
- T Ochiai
View Affiliations / Copyright

Affiliations: Second Department of Surgery, School of Medicine, Chiba University, Chuou-ku, Chiba-city 260-8670, Japan.
Pages: 333-341
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Published online on: March 1, 2000

https://doi.org/10.3892/or.7.2.333
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Abstract

Vascular endothelial growth factor (VEGF) is known as a potent inducer of angiogenesis in various human cancers. Serum VEGF concentrations of colorectal cancer patients was assessed for their clinical significance as a tumor marker. Serum samples were obtained at admission from 24 healthy volunteers and 111 patients with colorectal cancer. Preoperative serum VEGF concentrations, which are significantly higher than those of healthy controls, reflect clinical stage progression, depth of invasion, liver metastasis, lymph node metastasis and lymphatic invasion. Consequently, detection of VEGF could serve as a clinically useful marker for colorectal cancer progression and metastasis independent of other markers.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical significance of serum vascular endothelial growth factor in colorectal cancer patients: correlation with clinicopathological factors and tumor markers.

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Abstract

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