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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Mar-Apr 2000 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.

  • Authors:
    • R Kotchetkov
    • J Cinatl
    • J Matousek
    • J Vogel
    • P Pouckova
    • M Wagner
    • B Kornhuber
    • D Schwabe

  • View Affiliations / Copyright

    Affiliations: Center of Pediatrics, Department of Hematology and Oncology, Johann-Wolfgang Goethe University Clinic, 60528 Frankfurt am Main, Germany.
  • Pages: 363-370
    |
    Published online on: March 1, 2000
       https://doi.org/10.3892/or.7.2.363
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Abstract

Bovine seminal ribonuclease (BS-RNase) is a homologue of RNase A with specific antitumor activities. It is selectively toxic for neuroblastoma (NB) cells in vitro with no significant effects on the viability of normal human cells. We evaluated the antitumoral effects of BS-RNase on human NB xenografts from UKF-NB-3 cells in athymic (nude) mice. The efficacy of direct intraneoplastic, subcutaneous and systemic delivery of BS-RNase was explored. Systemic administration of BS-RNase (12.5 mg/kg/day intraperitoneally, for 20 days in the course of four weeks) suppressed tumor growth but was not able to induce any cures. Subcutaneous injections (12.5 mg/kg/day for 20 days in the course of four weeks) and intratumoral BS-RNase treatment using the same schedule resulted in complete tumor regression. During 30 days following cessation of treatment no tumor regrowth was observed and animals were free of tumors. Toxic effects of BS-RNase (e.g., on bone marrow and inner organs) were not apparent. This data indicates that BS-RNase fulfills important criteria for a candidate antitumor agent specific for NB.

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Copy and paste a formatted citation
Spandidos Publications style
Kotchetkov R, Cinatl J, Matousek J, Vogel J, Pouckova P, Wagner M, Kornhuber B and Schwabe D: Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.. Oncol Rep 7: 363-370, 2000.
APA
Kotchetkov, R., Cinatl, J., Matousek, J., Vogel, J., Pouckova, P., Wagner, M. ... Schwabe, D. (2000). Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.. Oncology Reports, 7, 363-370. https://doi.org/10.3892/or.7.2.363
MLA
Kotchetkov, R., Cinatl, J., Matousek, J., Vogel, J., Pouckova, P., Wagner, M., Kornhuber, B., Schwabe, D."Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.". Oncology Reports 7.2 (2000): 363-370.
Chicago
Kotchetkov, R., Cinatl, J., Matousek, J., Vogel, J., Pouckova, P., Wagner, M., Kornhuber, B., Schwabe, D."Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.". Oncology Reports 7, no. 2 (2000): 363-370. https://doi.org/10.3892/or.7.2.363
Copy and paste a formatted citation
x
Spandidos Publications style
Kotchetkov R, Cinatl J, Matousek J, Vogel J, Pouckova P, Wagner M, Kornhuber B and Schwabe D: Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.. Oncol Rep 7: 363-370, 2000.
APA
Kotchetkov, R., Cinatl, J., Matousek, J., Vogel, J., Pouckova, P., Wagner, M. ... Schwabe, D. (2000). Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.. Oncology Reports, 7, 363-370. https://doi.org/10.3892/or.7.2.363
MLA
Kotchetkov, R., Cinatl, J., Matousek, J., Vogel, J., Pouckova, P., Wagner, M., Kornhuber, B., Schwabe, D."Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.". Oncology Reports 7.2 (2000): 363-370.
Chicago
Kotchetkov, R., Cinatl, J., Matousek, J., Vogel, J., Pouckova, P., Wagner, M., Kornhuber, B., Schwabe, D."Bovine seminal ribonuclease inhibits in vivo growth of human neuroblastoma cells.". Oncology Reports 7, no. 2 (2000): 363-370. https://doi.org/10.3892/or.7.2.363
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