Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.

  • Authors:
    • M Sasaki
    • K Nakajima
    • G Perinchery
    • T Fujino
    • B R Oh
    • S Fujimoto
    • R Dahiya
  • View Affiliations

  • Published online on: March 1, 2000     https://doi.org/10.3892/or.7.2.369
  • Pages: 369-442
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Abstract

This study was designed to test the hypothesis that genotypic changes of tumor necrosis factor alpha (TNF-alpha) promoter region are associated with endometrial cancer. TNF-alpha gene encodes a cytokine involved in angiogenesis and oncogenesis of several cancers. Some uncommon alleles are reported to be associated with increased production of TNF-alpha and the onset of various cancers. Studies of such alleles are lacking in endometrial cancer. In this study, we examined the genetic changes at the polymorphic 3 loci of TNF-alpha promoter regions (-238, -308 and 488) in 41 Japanese patients with uterine endometrial carcinomas (UEC). Nine of 41 UEC samples (22%) had genotype changes from GA to A at -308 promoter region of the TNF-alpha gene. There were no genotype changes at -238 and 488 regions of TNF-alpha in UEC samples. The results of our study demonstrate for the first time that genotype changes from GA to A in UEC patients. We conclude that the genotype changes at -308 promoter region of TNF-alpha may play an essential role in the malignant transformation of endometrial cells.

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Mar-Apr 2000
Volume 7 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sasaki M, Nakajima K, Perinchery G, Fujino T, Oh B, Fujimoto S and Dahiya R: Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.. Oncol Rep 7: 369-442, 2000
APA
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., & Dahiya, R. (2000). Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.. Oncology Reports, 7, 369-442. https://doi.org/10.3892/or.7.2.369
MLA
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., Dahiya, R."Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.". Oncology Reports 7.2 (2000): 369-442.
Chicago
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., Dahiya, R."Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.". Oncology Reports 7, no. 2 (2000): 369-442. https://doi.org/10.3892/or.7.2.369