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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Mar-Apr 2000 Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.

  • Authors:
    • M Sasaki
    • K Nakajima
    • G Perinchery
    • T Fujino
    • B R Oh
    • S Fujimoto
    • R Dahiya

  • View Affiliations / Copyright

    Affiliations: Department of Urology (112F), University of California San Francisco and VA Medical Center, San Francisco, CA 94121, USA.
  • Pages: 369-442
    |
    Published online on: March 1, 2000
       https://doi.org/10.3892/or.7.2.369
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Abstract

This study was designed to test the hypothesis that genotypic changes of tumor necrosis factor alpha (TNF-alpha) promoter region are associated with endometrial cancer. TNF-alpha gene encodes a cytokine involved in angiogenesis and oncogenesis of several cancers. Some uncommon alleles are reported to be associated with increased production of TNF-alpha and the onset of various cancers. Studies of such alleles are lacking in endometrial cancer. In this study, we examined the genetic changes at the polymorphic 3 loci of TNF-alpha promoter regions (-238, -308 and 488) in 41 Japanese patients with uterine endometrial carcinomas (UEC). Nine of 41 UEC samples (22%) had genotype changes from GA to A at -308 promoter region of the TNF-alpha gene. There were no genotype changes at -238 and 488 regions of TNF-alpha in UEC samples. The results of our study demonstrate for the first time that genotype changes from GA to A in UEC patients. We conclude that the genotype changes at -308 promoter region of TNF-alpha may play an essential role in the malignant transformation of endometrial cells.

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Copy and paste a formatted citation
Spandidos Publications style
Sasaki M, Nakajima K, Perinchery G, Fujino T, Oh B, Fujimoto S and Dahiya R: Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.. Oncol Rep 7: 369-442, 2000.
APA
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., & Dahiya, R. (2000). Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.. Oncology Reports, 7, 369-442. https://doi.org/10.3892/or.7.2.369
MLA
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., Dahiya, R."Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.". Oncology Reports 7.2 (2000): 369-442.
Chicago
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., Dahiya, R."Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.". Oncology Reports 7, no. 2 (2000): 369-442. https://doi.org/10.3892/or.7.2.369
Copy and paste a formatted citation
x
Spandidos Publications style
Sasaki M, Nakajima K, Perinchery G, Fujino T, Oh B, Fujimoto S and Dahiya R: Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.. Oncol Rep 7: 369-442, 2000.
APA
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., & Dahiya, R. (2000). Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.. Oncology Reports, 7, 369-442. https://doi.org/10.3892/or.7.2.369
MLA
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., Dahiya, R."Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.". Oncology Reports 7.2 (2000): 369-442.
Chicago
Sasaki, M., Nakajima, K., Perinchery, G., Fujino, T., Oh, B., Fujimoto, S., Dahiya, R."Frequent genotype changes at -308 of the human tumor necrosis factor-alpha promoter region in human uterine endometrial cancer.". Oncology Reports 7, no. 2 (2000): 369-442. https://doi.org/10.3892/or.7.2.369
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