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Efficacy and safety profile of amifostine in the preoperative combined therapy of esophageal cancer patients.

  • Authors:
    • M Orditura
    • F De Vita
    • A Belli
    • F Ciaramella
    • M Musicò
    • A Ferrigno
    • R Formato
    • G Abbate
    • M R Diadema
    • G Catalano

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  • Published online on: March 1, 2000     https://doi.org/10.3892/or.7.2.397
  • Pages: 397-797
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Abstract

The aim of this study was to assess the protective effect and the safety profile of amifostine in 16 esophageal cancer patients undergoing neoadjuvant chemo-radiation therapy (group A) compared to 21 matched patients (group B), treated with the same schedule without receiving amifostine, and considered as controls. Haematological and extra-haematological toxicity were evaluated according to WHO criteria and considered as result of amifostine activity. The bone marrow toxicity was globally lower in group A than in group B. We recorded 4 cases of mucosities in group B compared to 1 case in group A. amifostine-related side effects were few (2 cases of hypotension and 1 of vomiting), mild, and well controlled. In conclusion, amifostine seems to be effective and safe when used as protective agent also in esophageal cancer.

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Mar-Apr 2000
Volume 7 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Orditura M, De Vita F, Belli A, Ciaramella F, Musicò M, Ferrigno A, Formato R, Abbate G, Diadema M, Catalano G, Catalano G, et al: Efficacy and safety profile of amifostine in the preoperative combined therapy of esophageal cancer patients.. Oncol Rep 7: 397-797, 2000
APA
Orditura, M., De Vita, F., Belli, A., Ciaramella, F., Musicò, M., Ferrigno, A. ... Catalano, G. (2000). Efficacy and safety profile of amifostine in the preoperative combined therapy of esophageal cancer patients.. Oncology Reports, 7, 397-797. https://doi.org/10.3892/or.7.2.397
MLA
Orditura, M., De Vita, F., Belli, A., Ciaramella, F., Musicò, M., Ferrigno, A., Formato, R., Abbate, G., Diadema, M., Catalano, G."Efficacy and safety profile of amifostine in the preoperative combined therapy of esophageal cancer patients.". Oncology Reports 7.2 (2000): 397-797.
Chicago
Orditura, M., De Vita, F., Belli, A., Ciaramella, F., Musicò, M., Ferrigno, A., Formato, R., Abbate, G., Diadema, M., Catalano, G."Efficacy and safety profile of amifostine in the preoperative combined therapy of esophageal cancer patients.". Oncology Reports 7, no. 2 (2000): 397-797. https://doi.org/10.3892/or.7.2.397