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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 2000 Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.

  • Authors:
    • R Yamaguchi
    • H Yano
    • Y Nakashima
    • S Ogasawara
    • K Higaki
    • J Akiba
    • D J Hicklin
    • M Kojiro

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
  • Pages: 725-734
    |
    Published online on: July 1, 2000
       https://doi.org/10.3892/or.7.4.725
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Abstract

Flt-1 (VEGF receptor-1) and KDR/Flk-1 (VEGF receptor-2) are the high-affinity receptors for the angiogenesis factor, vascular endothelial growth factor (VEGF). VEGF expression has been confirmed in human hepatocellular carcinoma (HCC), and VEGF is thought to be involved in the angiogenesis within HCC tissues. However, expressions of VEGF receptors in HCC have not been reported. We immunohistochemically examined expressions and localizations of Flt-1 and KDR in 28 surgically resected HCC tissues. In non-cancerous area, Flt-1 and KDR were mainly found in macrophages including Kupffer cells; both receptors were found in vascular endothelial cells in the portal veins and arteries within portal tracts; and KDR was also found in some sinusoidal endothelial cells. In cancerous area, Flt-1 and KDR were found in some macrophages, and also in the endothelial cells of intratumoral blood vessels. In 25 moderately and/or poorly differentiated HCCs, KDR expression in the blood space endothelial cells was clear and continuous in 20 cases, and focal in 5 cases. These results suggest that there would be an angiogenesis mechanism via VEGF/Flt-1 or VEGF/KDR in HCC, and the VEGF/KDR system would take a more important role.

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Copy and paste a formatted citation
Spandidos Publications style
Yamaguchi R, Yano H, Nakashima Y, Ogasawara S, Higaki K, Akiba J, Hicklin D and Kojiro M: Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.. Oncol Rep 7: 725-734, 2000.
APA
Yamaguchi, R., Yano, H., Nakashima, Y., Ogasawara, S., Higaki, K., Akiba, J. ... Kojiro, M. (2000). Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.. Oncology Reports, 7, 725-734. https://doi.org/10.3892/or.7.4.725
MLA
Yamaguchi, R., Yano, H., Nakashima, Y., Ogasawara, S., Higaki, K., Akiba, J., Hicklin, D., Kojiro, M."Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.". Oncology Reports 7.4 (2000): 725-734.
Chicago
Yamaguchi, R., Yano, H., Nakashima, Y., Ogasawara, S., Higaki, K., Akiba, J., Hicklin, D., Kojiro, M."Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.". Oncology Reports 7, no. 4 (2000): 725-734. https://doi.org/10.3892/or.7.4.725
Copy and paste a formatted citation
x
Spandidos Publications style
Yamaguchi R, Yano H, Nakashima Y, Ogasawara S, Higaki K, Akiba J, Hicklin D and Kojiro M: Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.. Oncol Rep 7: 725-734, 2000.
APA
Yamaguchi, R., Yano, H., Nakashima, Y., Ogasawara, S., Higaki, K., Akiba, J. ... Kojiro, M. (2000). Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.. Oncology Reports, 7, 725-734. https://doi.org/10.3892/or.7.4.725
MLA
Yamaguchi, R., Yano, H., Nakashima, Y., Ogasawara, S., Higaki, K., Akiba, J., Hicklin, D., Kojiro, M."Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.". Oncology Reports 7.4 (2000): 725-734.
Chicago
Yamaguchi, R., Yano, H., Nakashima, Y., Ogasawara, S., Higaki, K., Akiba, J., Hicklin, D., Kojiro, M."Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues.". Oncology Reports 7, no. 4 (2000): 725-734. https://doi.org/10.3892/or.7.4.725
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