Neoadjuvant intra-arterial infusion chemotherapy combined with hormonal therapy for locally advanced breast cancer.

  • Authors:
    • Y Yuyama
    • A Yagihashi
    • K Hirata
    • T Ohmura
    • Y Suzuki
    • J Okamoto
    • T Yamada
    • Y Okazaki
    • Y Watanabe
    • A Okazaki
    • K Toda
    • M Okazaki
    • T Yajima
    • H Kameshima
    • J Araya
    • N Watanabe
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/or.7.4.797
  • Pages: 797-1598
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Abstract

To determine the efficacy of combined neoadjuvant intra-arterial infusion chemotherapy and hormonal therapy for treating locally advanced breast cancer, we compared the outcomes of patients with or without this therapy, and also assessed histologic response. Ninety-four patients with locally advanced breast cancer (stage IIIa, 56; stage IIIb, 38). Nineteen stage IIIa and 17 stage IIIb patients received intra-arterial plus hormonal therapy while 37 stage IIIa and 21 stage IIIb patients with similar ages and follow-up durations did not. Treated patients received intra-arterial epirubicin plus oral medroxy-progesterone. Five-year disease-free survival rates were 77.5% for intra-arterially treated and 33.0% for other patients in stage IIIa, and 70.5% for intra-arterially treated and 38.1% for other patients in stage IIIb. Five-year overall survival rates were 94.4% for intra-arterially treated and 61.7% for other patients in stage IIIa, and 90.9% for intra-arterially treated and 56.3% for other patients in stage IIIb. Ten-year overall survival rates in stage IIIb were 90.9% for treated and 22.5% for other group patents. All differences were statistically significant (p<0.05). Good histologic response to intra-arterial therapy was seen in 75% of the primary tumors and 71% of involved lymph nodes. Neoadjuvant intra-arterial therapy with hormonal therapy yielded better survival rates than no intra-arterial therapy or our previous intra-arterial regimen.

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Jul-Aug 2000
Volume 7 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yuyama Y, Yagihashi A, Hirata K, Ohmura T, Suzuki Y, Okamoto J, Yamada T, Okazaki Y, Watanabe Y, Okazaki A, Okazaki A, et al: Neoadjuvant intra-arterial infusion chemotherapy combined with hormonal therapy for locally advanced breast cancer.. Oncol Rep 7: 797-1598, 2000
APA
Yuyama, Y., Yagihashi, A., Hirata, K., Ohmura, T., Suzuki, Y., Okamoto, J. ... Watanabe, N. (2000). Neoadjuvant intra-arterial infusion chemotherapy combined with hormonal therapy for locally advanced breast cancer.. Oncology Reports, 7, 797-1598. https://doi.org/10.3892/or.7.4.797
MLA
Yuyama, Y., Yagihashi, A., Hirata, K., Ohmura, T., Suzuki, Y., Okamoto, J., Yamada, T., Okazaki, Y., Watanabe, Y., Okazaki, A., Toda, K., Okazaki, M., Yajima, T., Kameshima, H., Araya, J., Watanabe, N."Neoadjuvant intra-arterial infusion chemotherapy combined with hormonal therapy for locally advanced breast cancer.". Oncology Reports 7.4 (2000): 797-1598.
Chicago
Yuyama, Y., Yagihashi, A., Hirata, K., Ohmura, T., Suzuki, Y., Okamoto, J., Yamada, T., Okazaki, Y., Watanabe, Y., Okazaki, A., Toda, K., Okazaki, M., Yajima, T., Kameshima, H., Araya, J., Watanabe, N."Neoadjuvant intra-arterial infusion chemotherapy combined with hormonal therapy for locally advanced breast cancer.". Oncology Reports 7, no. 4 (2000): 797-1598. https://doi.org/10.3892/or.7.4.797