Expressions of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor on angiogenesis in intestinal-type gastric carcinoma.

Sakatani,T; Okamoto,E; Tsujitani,S; Ikeguchi,M; Kaibara,N; Ito,H

doi:10.3892/or.7.4.831

Expressions of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor on angiogenesis in intestinal-type gastric carcinoma.

Authors:
- T Sakatani
- E Okamoto
- S Tsujitani
- M Ikeguchi
- N Kaibara
- H Ito
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Affiliations: First Department of Pathology, Faculty of Medicine, Tottori University, Yonago/Tottori 683-8503, Japan.
Published online on: July 1, 2000 https://doi.org/10.3892/or.7.4.831
Pages: 831-837

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Abstract

We examined the clinical and pathological significance of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor (VEGF) in human gastric carcinomas, in terms of intratumoral microvessel density (IMVD), P53 expression, and patient prognosis in a total of 128 patients. Mean IMVD was significantly higher in the carcinomas with dThdPase or VEGF expression than in carcinomas without the expression. The simultaneous expression of dThdPase and VEGF was correlated with increased IMVD of human gastric carcinomas. VEGF expression was associated with P53 expression and poor patient prognosis, but dThdPase expression was not.