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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Jul-Aug 2000 Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.

  • Authors:
    • D Delmas
    • B Jannin
    • M Cherkaoui Malki
    • N Latruffe
  • View Affiliations / Copyright

    Affiliations: LBMC, Molecular and Cellular Laboratory, University of Burgundy, 21000 Dijon, France.
  • Pages: 847-899
    |
    Published online on: July 1, 2000
       https://doi.org/10.3892/or.7.4.847
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Abstract

Resveratrol is a polyphenolic compound especially produced by grapevine and consequently found in wine. Based on epidemiological studies resveratrol may act as a cancer chemopreventive compound. The ability of resveratrol to inhibit cell proliferation was studied in rat hepatoma Fao cell line and human hepatoblastoma HepG2 cell line. The results show that resveratrol strongly inhibits cell proliferation at the micromolar range in a time- and dose-dependent manner. Concentrations higher than 50 microM become toxic. Fao cells are more sensitive than HepG2 cells. Interestingly, the presence of ethanol lowers the threshold of resveratrol effect. Resveratrol appears to prevent or to delay the entry to mitosis since no inhibition of [3H]thymidine incorporation is observed, while there is an increase of cell number in S and G2/M phases. In conclusion, resveratrol shows a strong inhibition of hepatic cell proliferation where alcohol may act as an enhancing agent.

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Copy and paste a formatted citation
Spandidos Publications style
Delmas D, Jannin B, Cherkaoui Malki M and Latruffe N: Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.. Oncol Rep 7: 847-899, 2000.
APA
Delmas, D., Jannin, B., Cherkaoui Malki, M., & Latruffe, N. (2000). Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.. Oncology Reports, 7, 847-899. https://doi.org/10.3892/or.7.4.847
MLA
Delmas, D., Jannin, B., Cherkaoui Malki, M., Latruffe, N."Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.". Oncology Reports 7.4 (2000): 847-899.
Chicago
Delmas, D., Jannin, B., Cherkaoui Malki, M., Latruffe, N."Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.". Oncology Reports 7, no. 4 (2000): 847-899. https://doi.org/10.3892/or.7.4.847
Copy and paste a formatted citation
x
Spandidos Publications style
Delmas D, Jannin B, Cherkaoui Malki M and Latruffe N: Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.. Oncol Rep 7: 847-899, 2000.
APA
Delmas, D., Jannin, B., Cherkaoui Malki, M., & Latruffe, N. (2000). Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.. Oncology Reports, 7, 847-899. https://doi.org/10.3892/or.7.4.847
MLA
Delmas, D., Jannin, B., Cherkaoui Malki, M., Latruffe, N."Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.". Oncology Reports 7.4 (2000): 847-899.
Chicago
Delmas, D., Jannin, B., Cherkaoui Malki, M., Latruffe, N."Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.". Oncology Reports 7, no. 4 (2000): 847-899. https://doi.org/10.3892/or.7.4.847
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