Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.

  • Authors:
    • D Delmas
    • B Jannin
    • M Cherkaoui Malki
    • N Latruffe
  • View Affiliations

  • Published online on: July 1, 2000     https://doi.org/10.3892/or.7.4.847
  • Pages: 847-899
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Abstract

Resveratrol is a polyphenolic compound especially produced by grapevine and consequently found in wine. Based on epidemiological studies resveratrol may act as a cancer chemopreventive compound. The ability of resveratrol to inhibit cell proliferation was studied in rat hepatoma Fao cell line and human hepatoblastoma HepG2 cell line. The results show that resveratrol strongly inhibits cell proliferation at the micromolar range in a time- and dose-dependent manner. Concentrations higher than 50 microM become toxic. Fao cells are more sensitive than HepG2 cells. Interestingly, the presence of ethanol lowers the threshold of resveratrol effect. Resveratrol appears to prevent or to delay the entry to mitosis since no inhibition of [3H]thymidine incorporation is observed, while there is an increase of cell number in S and G2/M phases. In conclusion, resveratrol shows a strong inhibition of hepatic cell proliferation where alcohol may act as an enhancing agent.

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Jul-Aug 2000
Volume 7 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Delmas D, Jannin B, Cherkaoui Malki M and Latruffe N: Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.. Oncol Rep 7: 847-899, 2000
APA
Delmas, D., Jannin, B., Cherkaoui Malki, M., & Latruffe, N. (2000). Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.. Oncology Reports, 7, 847-899. https://doi.org/10.3892/or.7.4.847
MLA
Delmas, D., Jannin, B., Cherkaoui Malki, M., Latruffe, N."Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.". Oncology Reports 7.4 (2000): 847-899.
Chicago
Delmas, D., Jannin, B., Cherkaoui Malki, M., Latruffe, N."Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines.". Oncology Reports 7, no. 4 (2000): 847-899. https://doi.org/10.3892/or.7.4.847