Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice

  • Authors:
    • C. Maruyama
    • M. Tomisawa
    • S. Wakana
    • H. Yamazaki
    • H. Kijima
    • H. Suemizu
    • Y. Ohnishi
    • K. Urano
    • K. Hioki
    • T. Usui
    • M. Nakamura
    • T. Tsuchida
    • K. Mitsumori
    • T. Nomura
    • N. Tamaoki
    • Y. Ueyama
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/or.8.2.233
  • Pages: 233-237
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Abstract

Level of human prototype H-ras transgene expression in tumors induced by chemical carcinogens (N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea) was analyzed in human H-ras transgenic mice (CB6F1-TgrasH2 Jic mice). All forestomach tumors examined revealed about 2-fold overexpression of the human H-ras transgene with or without point mutation at codon 12 or codon 61. However, endogenous mouse H- and K-ras genes exhibited neither point mutation nor overexpression. These results suggested that increased levels of ras gene products in the cell played an important role in facilitating chemical carcinogenesis in transgenic mice.

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March-April 2001
Volume 8 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Maruyama C, Tomisawa M, Wakana S, Yamazaki H, Kijima H, Suemizu H, Ohnishi Y, Urano K, Hioki K, Usui T, Usui T, et al: Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice. Oncol Rep 8: 233-237, 2001.
APA
Maruyama, C., Tomisawa, M., Wakana, S., Yamazaki, H., Kijima, H., Suemizu, H. ... Ueyama, Y. (2001). Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice. Oncology Reports, 8, 233-237. https://doi.org/10.3892/or.8.2.233
MLA
Maruyama, C., Tomisawa, M., Wakana, S., Yamazaki, H., Kijima, H., Suemizu, H., Ohnishi, Y., Urano, K., Hioki, K., Usui, T., Nakamura, M., Tsuchida, T., Mitsumori, K., Nomura, T., Tamaoki, N., Ueyama, Y."Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice". Oncology Reports 8.2 (2001): 233-237.
Chicago
Maruyama, C., Tomisawa, M., Wakana, S., Yamazaki, H., Kijima, H., Suemizu, H., Ohnishi, Y., Urano, K., Hioki, K., Usui, T., Nakamura, M., Tsuchida, T., Mitsumori, K., Nomura, T., Tamaoki, N., Ueyama, Y."Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice". Oncology Reports 8, no. 2 (2001): 233-237. https://doi.org/10.3892/or.8.2.233