Interleukin-6 and its relationships to acute phase proteins in serous effusion differentiation

  • Authors:
    • Michael G. Alexandrakis
    • Despina S. Kyriakou
    • Demosthenes Bouros
    • Irene Xylouri
    • Nikolaos Antonakis
    • Nikolaos M. Siafakas
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/or.8.2.415
  • Pages: 415-420
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Abstract

The aim of the study was to assess the discriminative power of cytokine interleukin 6 (IL-6) between transudative and exudative pleural and peritoneal effusions, and to compare IL-6 with common acute phase proteins in serous effusion differentiation. One hundred and forty-five consecutive patients with pleural or peritoneal effusion underwent diagnostic parecentesis. Patients were categorized in three groups. Malignant effusion (group A) 56 patients, non-malignant effusion (group B) 46 patients and transudate (group C) 43 patients. Serum and effusion levels of IL-6, C-reactive protein (CRP), α2-macroglobuline (α2-MG), α1-antitrypsin (α1-AT) and α1-acid glycoprotein (α1-AG) were determined. Serum IL-6 levels were significantly higher in groups A and B in comparison to group C (p<0.001 and 0.001, respectively). In addition, serum IL-6 levels were higher in group A compared to group B (p<0.001), while the studied acute phase proteins were not significantly different. All the studied parameters were higher in the effusions of groups A and B compared to group C. At a cut-off value of 72.1 fmol/ml IL-6 had a sensitivity of 82.6-89.3%, specificity of 88.4-90.7% and positive predictive value of 90.7-94.6% among the three groups. Our results suggest that IL-6 at levels ≥72.1 fmol/ml, α1-AT at ≥170 mg/dl and α1-AG at ≥52.3 mg/ml give strong evidences for malignancy in exudates.

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March-April 2001
Volume 8 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Alexandrakis MG, Kyriakou DS, Bouros D, Xylouri I, Antonakis N and Siafakas NM: Interleukin-6 and its relationships to acute phase proteins in serous effusion differentiation. Oncol Rep 8: 415-420, 2001
APA
Alexandrakis, M.G., Kyriakou, D.S., Bouros, D., Xylouri, I., Antonakis, N., & Siafakas, N.M. (2001). Interleukin-6 and its relationships to acute phase proteins in serous effusion differentiation. Oncology Reports, 8, 415-420. https://doi.org/10.3892/or.8.2.415
MLA
Alexandrakis, M. G., Kyriakou, D. S., Bouros, D., Xylouri, I., Antonakis, N., Siafakas, N. M."Interleukin-6 and its relationships to acute phase proteins in serous effusion differentiation". Oncology Reports 8.2 (2001): 415-420.
Chicago
Alexandrakis, M. G., Kyriakou, D. S., Bouros, D., Xylouri, I., Antonakis, N., Siafakas, N. M."Interleukin-6 and its relationships to acute phase proteins in serous effusion differentiation". Oncology Reports 8, no. 2 (2001): 415-420. https://doi.org/10.3892/or.8.2.415