Application of an adapted international prognostic index for aggressive non-Hodgkin's lymphomas: Good discrimination and lower survival rates in Rio de Janeiro, Brazil

  • Authors:
    • Irene Biasoli
    • Jose Carlos Morais
    • Patricia Soares de Jesus
    • Wolmar Pulcheri
    • Marcio Nucci
    • Nelson Spector
  • View Affiliations

  • Published online on: March 1, 2001     https://doi.org/10.3892/or.8.2.441
  • Pages: 441-444
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Abstract

Institutions that treat patients with lymphoma must know their local therapy results and adapt their treatment strategies accordingly. To allow the application of the international prognostic factor index (IPI) in institutions where some of the data necessary are not available, we devised an approach by which the missing data would not impair the applicability of the index. We also collapsed the four categories of the IPI into two categories, and applied this adapted IPI to patients with aggressive non-Hodgkin's lymphoma treated in a public university hospital. Among the 72 patients treated with combination chemotherapy regimens containing doxorubicin, the following outcomes were observed for low and high risk groups, respectively: complete remission rates were 62% and 45% (p=0.2), overall survival rates were 48% and 14% (p=0.0098) and failure-free survival rates were 44% and 17% (p=0.03). This adapted IPI was very effective in predicting the outcome in the patients studied. The survival rates observed in our population were substantially lower than the rates reported in the IPI study. Patient selection might have played an important role in this difference, although other factors related to the social and general health status of the patients treated need to be prospectively studied.

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March-April 2001
Volume 8 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Biasoli I, Morais JC, Soares de Jesus P, Pulcheri W, Nucci M and Spector N: Application of an adapted international prognostic index for aggressive non-Hodgkin's lymphomas: Good discrimination and lower survival rates in Rio de Janeiro, Brazil. Oncol Rep 8: 441-444, 2001.
APA
Biasoli, I., Morais, J.C., Soares de Jesus, P., Pulcheri, W., Nucci, M., & Spector, N. (2001). Application of an adapted international prognostic index for aggressive non-Hodgkin's lymphomas: Good discrimination and lower survival rates in Rio de Janeiro, Brazil. Oncology Reports, 8, 441-444. https://doi.org/10.3892/or.8.2.441
MLA
Biasoli, I., Morais, J. C., Soares de Jesus, P., Pulcheri, W., Nucci, M., Spector, N."Application of an adapted international prognostic index for aggressive non-Hodgkin's lymphomas: Good discrimination and lower survival rates in Rio de Janeiro, Brazil". Oncology Reports 8.2 (2001): 441-444.
Chicago
Biasoli, I., Morais, J. C., Soares de Jesus, P., Pulcheri, W., Nucci, M., Spector, N."Application of an adapted international prognostic index for aggressive non-Hodgkin's lymphomas: Good discrimination and lower survival rates in Rio de Janeiro, Brazil". Oncology Reports 8, no. 2 (2001): 441-444. https://doi.org/10.3892/or.8.2.441