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Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia

  • Authors:
    • Nathalie Henriques Silva
    • Glicinia Pimenta
    • Wolmar Alcantara Pulcheri
    • Marcia Vasconcellos Fournier
    • Nelson Spector
    • M. G. da Costa Carvalho

  • View Affiliations

  • Published online on: May 1, 2001     https://doi.org/10.3892/or.8.3.693
  • Pages: 693-696
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Abstract

We investigated the presence of free mRNA in the plasma of patients with chronic myeloid leukemia (CML), through RT-PCR analysis of G3PDH, a metabolism gene. We also analysed the presence of mRNA for HLM, a human oxysterol-binding protein homologue recently described as a potential marker for blood dissemination of solid tumors. Our results showed the presence of metabolism G3PDH mRNA in the plasma of 5/11 (45%) CML patients studied but HLM mRNA was not detected in any of the plasma studied. HLM mRNA was detected in the leukocytes of 4/5 (80%) CML patients. This work reports for the first time free mRNA in the plasma of CML patients. Our results also suggest that the detection of HLM could be a potential molecular marker for the follow-up in hematological malignancies.

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May-June 2001
Volume 8 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Silva NH, Pimenta G, Pulcheri WA, Fournier MV, Spector N and da Costa Carvalho MG: Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia. Oncol Rep 8: 693-696, 2001
APA
Silva, N.H., Pimenta, G., Pulcheri, W.A., Fournier, M.V., Spector, N., & da Costa Carvalho, M.G. (2001). Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia. Oncology Reports, 8, 693-696. https://doi.org/10.3892/or.8.3.693
MLA
Silva, N. H., Pimenta, G., Pulcheri, W. A., Fournier, M. V., Spector, N., da Costa Carvalho, M. G."Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia". Oncology Reports 8.3 (2001): 693-696.
Chicago
Silva, N. H., Pimenta, G., Pulcheri, W. A., Fournier, M. V., Spector, N., da Costa Carvalho, M. G."Detection of messenger RNA in leukocytes or plasma of patients with chronic myeloid leukemia". Oncology Reports 8, no. 3 (2001): 693-696. https://doi.org/10.3892/or.8.3.693