Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: Relationship with prognostic factors

  • Authors:
    • Youqing Xu
    • Noriko Kimura
    • Ryuichi Yoshida
    • Hitoshi Lin
    • Kaoru Yoshinaga
  • View Affiliations

  • Published online on: September 1, 2001     https://doi.org/10.3892/or.8.5.1177
  • Pages: 1177-1182
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Abstract

We investigated the expression of mucin core proteins, Muc1, Muc2, and human gastric mucin (HGM) immunohistochemically in 5 non-invasive, 62 invasive ductal carcinomas and 3 mucinous carcinomas of the breast and statistically examined the relationship with prognostic factors. Muc1 was expressed in almost all breast carcinomas and there was a reverse correlation with tumor size (r=-0.25). However, Muc1 was not significantly correlated with the other tumor characteristics such as lymphocytic infiltration, axillary lymph node metastasis, TNM and plasma levels of CA153. Muc2 and HGM were expressed in 5 cases each in invasive ductal carcinomas, 0 and 3 in non-invasive ductal carcinomas, and 2 and 1 in mucinous carcinomas, respectively. Muc 2 expression correlated with lymph node metastasis. HGM was found in the tumors without lymph node metastasis and lower levels of serum CA153.

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September-October 2001
Volume 8 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xu Y, Kimura N, Yoshida R, Lin H and Yoshinaga K: Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: Relationship with prognostic factors. Oncol Rep 8: 1177-1182, 2001
APA
Xu, Y., Kimura, N., Yoshida, R., Lin, H., & Yoshinaga, K. (2001). Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: Relationship with prognostic factors. Oncology Reports, 8, 1177-1182. https://doi.org/10.3892/or.8.5.1177
MLA
Xu, Y., Kimura, N., Yoshida, R., Lin, H., Yoshinaga, K."Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: Relationship with prognostic factors". Oncology Reports 8.5 (2001): 1177-1182.
Chicago
Xu, Y., Kimura, N., Yoshida, R., Lin, H., Yoshinaga, K."Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: Relationship with prognostic factors". Oncology Reports 8, no. 5 (2001): 1177-1182. https://doi.org/10.3892/or.8.5.1177