Absence of Bcl10 gene mutations in Ewing's sarcomas

  • Authors:
    • Yong-Koo Park
    • Sung-Gil Chi
    • K. Krishnan Unni
  • View Affiliations

  • Published online on: November 1, 2001     https://doi.org/10.3892/or.8.6.1333
  • Pages: 1333-1335
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Abstract

The Bcl10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32) in mucosa-associated lymphoid tissue (MALT) lymphomas. Somatic mutations of Bcl10 were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other tumors. To clarify the actual frequency and spectrum of Bcl10 mutations in primary malignant Ewing's sarcomas, we examined 31 cases of Ewing's sarcomas. Polymerase chain reaction single-stranded conformation polymorphism (PCR-SSCP) and sequencing analyses were done. No Bcl10 mutations were found in our series of Ewing's sarcomas. While screening for mutations, we found three polymorphisms at codons 8 exon 1 of the Bcl10 gene. Our results strongly suggest that somatic mutations of Bcl10 are extremely rare in Ewing's sarcomas and do not commonly contribute to their molecular pathogenesis.

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November-December 2001
Volume 8 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Park Y, Chi S and Unni KK: Absence of Bcl10 gene mutations in Ewing's sarcomas. Oncol Rep 8: 1333-1335, 2001.
APA
Park, Y., Chi, S., & Unni, K.K. (2001). Absence of Bcl10 gene mutations in Ewing's sarcomas. Oncology Reports, 8, 1333-1335. https://doi.org/10.3892/or.8.6.1333
MLA
Park, Y., Chi, S., Unni, K. K."Absence of Bcl10 gene mutations in Ewing's sarcomas". Oncology Reports 8.6 (2001): 1333-1335.
Chicago
Park, Y., Chi, S., Unni, K. K."Absence of Bcl10 gene mutations in Ewing's sarcomas". Oncology Reports 8, no. 6 (2001): 1333-1335. https://doi.org/10.3892/or.8.6.1333